Genomic News and Research

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IDC announces recipients of HPC Innovation Excellence Award at ISC'13

International Data Corporation today announced the fifth round of recipients of the HPC Innovation Excellence Award at the ISC'13 supercomputer industry conference in Leipzig, Germany. Prior winners were announced at the ISC'11, SC'11, ISC'12, and SC'12 supercomputing conferences.

18 Jun 2013

Genomic instability in new molecular pathway may predict worse outcomes in breast cancer patients

A new molecular pathway involving the gene ZNF365 has been identified and abnormalities in that pathway may predict worse outcomes for patients with breast cancer, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research.

18 Jun 2013

MGH researchers discover CNVs in members of 10 families with early-onset Alzheimer's

Although a family history of Alzheimer's disease is a primary risk factor for the devastating neurological disorder, mutations in only three genes - the amyloid precursor protein and presenilins 1 and 2 - have been established as causative for inherited, early-onset Alzheimer's, accounting for about half of such cases.

18 Jun 2013

Researchers produce first genome-wide investigation of cap-independent translation

Because of their central importance to biology, proteins have been the focus of intense research, particularly the manner in which they are produced from genetically coded templates-a process commonly known as translation. While the general mechanism of translation has been understood for some time, protein synthesis can initiate by more than one mechanism. One of the least well understood mechanisms is known as cap-independent translation.

17 Jun 2013

HandsFree system helps analyze next generation sequencing data

In the early 1990s, an international effort was launched by the U.S. Department of Energy and the National Institutes of Health to sequence the human genome. The project took 13 years, involved many scientists in several countries, and cost $2.7 billion (in FY 1991) dollars.

15 Jun 2013

Gene variants may predict which women are most likely to benefit from breast cancer therapy

In women at high risk for breast cancer, a long-term drug treatment can cut the risk of developing the disease in half. Researchers supported by the National Institutes of Health have now identified two gene variants that may predict which women are most likely to benefit from this therapy—and which should avoid it.

14 Jun 2013

Johns Hopkins scientists receive grants to research on genome-based test for cancer

An anonymous donor has given $500,000 to conduct large-scale clinical trials and laboratory research on the "PapGene" test, a genomic-based screening test that detects ovarian and endometrial cancers in cervical fluid.

14 Jun 2013

Researchers at Albert Einstein College of Medicine convene one-day conference on Jewish genetics

Today, researchers at Albert Einstein College of Medicine of Yeshiva University convened a one-day conference on Jewish genetics designed to encourage collaboration and advance the field of research.

14 Jun 2013

Supreme Court invalidates patents held by Myriad Genetics

The College of American Pathologists applauds today's unanimous Supreme Court decision invalidating the patents held by Myriad Genetics on the BRCA1 and BRCA2 genes. It is a victory for patients and for science.

14 Jun 2013

Genetic variations may help predict breast cancer risk in women who receive preventive therapy

Newly discovered genetic variations may help predict breast cancer risk in women who receive preventive breast cancer therapy with the selective estrogen receptor modulator drugs tamoxifen and raloxifene, a Mayo Clinic-led study has found. The study is published in the journal Cancer Discovery.

14 Jun 2013

Findings provide basis for reinvigoration of research efforts in breast cancer prevention

Genetic variations, known as single nucleotide polymorphisms, in or near the genes ZNF423 and CTSO were associated with breast cancer risk among women who underwent prevention therapy with tamoxifen and raloxifene, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research.

14 Jun 2013

Ambry Genetics introduces BRCA1 and BRCA2 analysis

Ambry Genetics announced today the launch of BRCA1 and BRCA2 analysis as part of their comprehensive cancer-testing menu. Two genes will be offered as a stand alone test comprising of full gene sequencing and deletion/duplication analyses in addition to being incorporated as part of multiple hereditary cancer panels that test cancer susceptibility genes using next-generation sequencing technology.

14 Jun 2013

TEDDY study enables scientists to parse genetic mutations associated with type 1 diabetes

Massive samples emanating from a decade-old, international initiative to determine how genetics and environment cause type 1 diabetes are giving scientists a unique perspective on which molecular and environmental factors really contribute to the disease.

14 Jun 2013

Prostate cancer and DNA: an interview with Dr. Jianfeng Xu, Wake Forest School of Medicine

Prostate cancer development is associated with both inherited and acquired genetic alterations. More than 70 inherited genetic variants have been consistently identified in human DNA that may contribute to susceptibility or risk of prostate cancer.

11 Jun 2013

Researchers find new way to repair genetic defects in the skin cells of epidermolysis bullosa patients

A research team led by pediatric blood and marrow transplantation experts Mark Osborn, Ph.D. and Jakub Tolar, M.D., Ph.D. from the Masonic Cancer Center, University of Minnesota, have discovered a remarkable new way to repair genetic defects in the skin cells of patients with the skin disease epidermolysis bullosa.

10 Jun 2013

Human Argonautes directly cuts messenger RNA

Human Argonautes (hAgo), are key proteins involved in a process known as RNA interference. RNAi, as it is often called, is a mechanism that cells use to regulate gene expression.

7 Jun 2013

Researchers demonstrate how young genes acquire essential functions

Researchers from UConn and other institutions in the U.S. and abroad have shown how a relatively young gene can acquire a new function and become essential to an organism's life.

7 Jun 2013

Researchers define nine molecular hallmarks of aging, debunk myths related to antioxidants

For some species, living twice as long in good health depends on no more than a few genes. When this fact was revealed by studies on worms three decades ago, it ushered in a golden age of ageing studies that has delivered numerous results, but also sown some confusion.

7 Jun 2013

Molecular subtyping can predict chemotherapy benefit in patients with colorectal cancer

Molecular subtyping can help predict outcomes and chemotherapy benefit in patients with colorectal cancer, according to a presentation at the annual conference of the American Society of Clinical Oncology (ASCO).

6 Jun 2013

Study shows success in pinpointing individualized treatment for women with metastatic breast cancer

Funded by volleyball tournaments, a new study released this week shows success in pinpointing individualized treatment for women with metastatic breast cancer, according to George Mason University researchers.

6 Jun 2013

Genomic News and Research

IDC announces recipients of HPC Innovation Excellence Award at ISC'13

Genomic instability in new molecular pathway may predict worse outcomes in breast cancer patients

MGH researchers discover CNVs in members of 10 families with early-onset Alzheimer's

Researchers produce first genome-wide investigation of cap-independent translation

HandsFree system helps analyze next generation sequencing data

Gene variants may predict which women are most likely to benefit from breast cancer therapy

Johns Hopkins scientists receive grants to research on genome-based test for cancer

Researchers at Albert Einstein College of Medicine convene one-day conference on Jewish genetics

Supreme Court invalidates patents held by Myriad Genetics

Genetic variations may help predict breast cancer risk in women who receive preventive therapy

Findings provide basis for reinvigoration of research efforts in breast cancer prevention

Ambry Genetics introduces BRCA1 and BRCA2 analysis

TEDDY study enables scientists to parse genetic mutations associated with type 1 diabetes

Prostate cancer and DNA: an interview with Dr. Jianfeng Xu, Wake Forest School of Medicine

Researchers find new way to repair genetic defects in the skin cells of epidermolysis bullosa patients

Human Argonautes directly cuts messenger RNA

Researchers demonstrate how young genes acquire essential functions

Researchers define nine molecular hallmarks of aging, debunk myths related to antioxidants

Molecular subtyping can predict chemotherapy benefit in patients with colorectal cancer

Study shows success in pinpointing individualized treatment for women with metastatic breast cancer

The art of CRISPR: The power and promise of gene editing eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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