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New research on DNA-repair enzyme could help enhance cancer drug development

Researchers from Rice University and St. Jude Children's Research Hospital in Memphis, Tennessee, took a close look at one of ways cells repair broken strands of DNA and discovered details that could help make a particular enzyme a promising target for precision cancer therapy.

6 Jan 2023

Hair follicle transplants can rejuvenate scars, study finds

In a new study involving three volunteers, skin scars began to behave more like uninjured skin after they were treated with hair follicle transplants.

6 Jan 2023

Cells live longer when they exchange metabolic products with each other

When cells exchange metabolic products with other cells, they live longer. This new finding comes from a research team at Charité – Universitätsmedizin Berlin, which made the discovery in a study using yeast cells.

6 Jan 2023

Pan-vaccine antigen strategy confers protection against cross-clade SARS-CoV-2 variants, including vaccine-resistant Omicron variants

Researchers developed a novel pan-vaccine antigen (Span)-based subunit vaccine against COVID-19.

6 Jan 2023

Study shows XBB.1.5 exhibits a substantially higher hACE2-binding affinity compared to BQ.1.1 and XBB/XBB.1

Researchers investigated the reasons for the rapid advent of SARS-CoV-2 XBB.1.5, a sublineage of the Omicron recombinant mutant XBB in the USA.

6 Jan 2023

High affinity antibodies isolated to safely target Claudin 6-positive tumors

Integral Molecular, the industry leader in antibody discovery for membrane proteins, has published the targeting mechanism enabling best-in-class specificity of its Claudin 6 (CLDN6) antibody CTIM-76 being developed for cancer therapy with Context Therapeutics.

6 Jan 2023

Study offers novel insights into the elongation dynamics of eukaryotic cells

Life depends on the precise functioning of several proteins synthesized in cells by ribosomes. This diverse set of proteins, known as a proteome, is maintained by the robust translation elongation of amino acid sequences taking place in the ribosomes.

5 Jan 2023

Study details the “immunometabolic editing” mechanism of tumor evolution

A Ludwig Cancer Research study has discovered that the immune system's surveillance of cancer can itself induce metabolic adaptations in the cells of early-stage tumors that simultaneously promote their growth and equip them to suppress lethal immune responses.

5 Jan 2023

Researchers reveal previously unknown properties of T cells

Certain T cells can secrete cytokines that are normally part of the innate immune system, as researchers from the Leibniz Institute for Natural Product Research and Infection Biology and an international research team discovered.

5 Jan 2023

Researchers elucidate the mechanism behind the formation of pores in mitochondrial membrane

Mitochondria are considered to be the power plants of cells and are essential for human metabolism. Dysfunction in 40 percent of mitochondrial proteins are associated with human diseases, which is why mitochondria also play an important role in medical research.

5 Jan 2023

Free spike proteins in the blood appear to play a role in myocarditis post-COVID mRNA vaccine

A recent study published in the journal Circulation examines the immunological picture in this scenario, looking for clues to the etiology of this rare and potentially serious complication.

5 Jan 2023

Scientists pinpoint the routes taken by SARS-CoV-2 to enter and exit cells in our nasal cavity

Somebody just coughed on you. On a plane. At a dinner party. In a supermarket line. If only there were a "morning after" nasal spray that could knock out respiratory viruses' ability to colonize your nose and throat.

5 Jan 2023

Immune system B-cells may be better in predicting HER2-positive breast cancer treatment response

Researchers at UNC Lineberger Comprehensive Cancer Center and colleagues have found that measuring activation of immune-system B cells may be better than measuring either T-cell activation or the total number of immune cells in and around a tumor, called tumor-infiltrating lymphocytes (TILs), in predicting whether HER2-positive breast cancer responds to treatment.

5 Jan 2023

What is the role of SARS-CoV-2 non-structural protein 2 in repressing host antiviral immunity?

Researchers uncovered a novel mechanism that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses (CoVs) use to exploit host antiviral immune system to facilitate their replication.

5 Jan 2023

Wayne State researcher wins $1.7 million NIH award to understand and tackle cisplatin-induced ototoxicity

A Wayne State University researcher has received a $1.7 million, five-year award from the National Institute on Deafness and Other Communication Disorders of the National Institutes of Health for the study, "Targeting nitrative stress for treatment of cisplatin ototoxicity."

5 Jan 2023

SynGAP Research Fund awards $180,000 grant to the University of Edinburgh Medical School's Patrick Wild Centre & Centre for Discovery Brain Sciences

SynGAP Research Fund (SRF), a 501(c)(3) public charity whose mission is to improve the quality of life for SYNGAP1 patients through the research and development of treatments, therapies and support systems, along with SynGAP Research Fund UK, today announced they have awarded a $180,000 grant to the University of Edinburgh Medical School's Patrick Wild Centre & Centre for Discovery Brain Sciences to advance the science around gene transfer to correct SYNGAP1 haploinsufficiency.

5 Jan 2023

New research extensively explores 12 distinctive aging traits

In a recent article published in Cell, researchers proposed that 12 distinctive traits of aging are all inter-related.

5 Jan 2023

Study shows angiotensin-converting enzyme 2 decoy protein as a promising anti-SARS-CoV-2 agent

Researchers presented a microbody recombinant decoy protein with high affinity to angiotensin-converting enzyme 2 (ACE2) as an option for coronavirus disease 2019 (COVID-19) treatment.

5 Jan 2023

PhoreMost and Boehringer Ingelheim enter multi-project drug discovery collaboration

PhoreMost Limited, the UK-based biopharmaceutical company dedicated to drugging ‘undruggable’ disease targets, today announced it has entered into a multi-project drug discovery collaboration with Boehringer Ingelheim, one of the world-leading pharmaceutical companies developing innovative therapies for diseases with unsatisfactory treatments.

From PhoreMost 5 Jan 2023

Mediterranean diet may benefit health in part by incorporating moderate wine consumption

Many public health warnings have been issued against alcohol consumption, even in small quantities, though the evidence for such strict limits is controversial. The current study, published in the MDPI journal Nutrients, is a narrative review focused on clearing up some of the confusion associated with alcoholic drinks.

4 Jan 2023

Protein C News and Research

New research on DNA-repair enzyme could help enhance cancer drug development

Hair follicle transplants can rejuvenate scars, study finds

Cells live longer when they exchange metabolic products with each other

Pan-vaccine antigen strategy confers protection against cross-clade SARS-CoV-2 variants, including vaccine-resistant Omicron variants

Study shows XBB.1.5 exhibits a substantially higher hACE2-binding affinity compared to BQ.1.1 and XBB/XBB.1

High affinity antibodies isolated to safely target Claudin 6-positive tumors

Study offers novel insights into the elongation dynamics of eukaryotic cells

Study details the “immunometabolic editing” mechanism of tumor evolution

Researchers reveal previously unknown properties of T cells

Researchers elucidate the mechanism behind the formation of pores in mitochondrial membrane

Free spike proteins in the blood appear to play a role in myocarditis post-COVID mRNA vaccine

Scientists pinpoint the routes taken by SARS-CoV-2 to enter and exit cells in our nasal cavity

Immune system B-cells may be better in predicting HER2-positive breast cancer treatment response

What is the role of SARS-CoV-2 non-structural protein 2 in repressing host antiviral immunity?

Wayne State researcher wins $1.7 million NIH award to understand and tackle cisplatin-induced ototoxicity

SynGAP Research Fund awards $180,000 grant to the University of Edinburgh Medical School's Patrick Wild Centre & Centre for Discovery Brain Sciences

New research extensively explores 12 distinctive aging traits

Study shows angiotensin-converting enzyme 2 decoy protein as a promising anti-SARS-CoV-2 agent

PhoreMost and Boehringer Ingelheim enter multi-project drug discovery collaboration

Mediterranean diet may benefit health in part by incorporating moderate wine consumption

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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