Therapeutics News and Research

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UC San Diego researchers receive new grant to advance malaria research

An international research team, led by principal investigator Elizabeth A. Winzeler, PhD, professor in the pediatric division of host-microbe systems and therapeutics at University of California San Diego School of Medicine, and colleagues have received a three-year, $4.7 million supplemental grant from the Bill & Melinda Gates Foundation to advance their development of improved therapies for malaria eradication and elimination.

17 Feb 2017

Research provides more evidence that mRNA vaccines can protect mice against Zika virus

Vaccine developers have successfully protected mice against Zika by injecting synthetic messenger RNA that encodes for virus proteins into the animals.

17 Feb 2017

New study confirms role of PAK4 protein in growth, spread of pancreatic cancer cells

A new study that confirms the role of a protein called PAK4 in the movement and growth of pancreatic cancer cells could help researchers find new ways to tackle the disease.

17 Feb 2017

Scientists map vast spider web of cancer proteins to reveal new drug targets

Scientists at Winship Cancer Institute of Emory University have mapped a vast spider web of interactions between proteins in lung cancer cells, as part of an effort to reach what was considered "undruggable."

17 Feb 2017

Glowing mice could mark major step forward for new gene therapy

Timothy Blake, a postdoctoral fellow in the Waymouth lab, was hard at work on a fantastical interdisciplinary experiment. He and his fellow researchers were refining compounds that would carry instructions for assembling the protein that makes fireflies light up and deliver them into the cells of an anesthetized mouse. If their technique worked, the mouse would glow in the dark.

16 Feb 2017

Salk scientists use mRNA to successfully treat hemophilia B in mice

FedEx, UPS, DHL--when it comes to sending packages, choices abound. But the most important delivery service you may not have heard of mRNA.

16 Feb 2017

Signals from fat cells may aid in diagnostics for metabolic conditions

Fat cells are not simply big blobs of lipid quietly standingby in the body--instead, they send out hormones and other signaling proteins that affect many types of tissues.

15 Feb 2017

Research opens treatment pathways for cancers that do not respond to targeted antibodies

By hijacking a cancer cell's own metabolism, researchers have found a way to tag and target elusive cancers with small-molecule sugars. This opens treatment pathways for cancers that are not responsive to conventional targeted antibodies, such as triple-negative breast cancer.

15 Feb 2017

Penn Medicine's ODC collaborates with FAST to develop gene therapy for Angelman syndrome

Penn Medicine's Orphan Disease Center announces a new partnership with FAST to study gene therapy approaches to treat Angelman syndrome.

14 Feb 2017

Study finds reduction in HbA1c levels with in-home use of hybrid closed-loop insulin delivery system

A pivotal registration trial to evaluate in-home use of the Medtronic MiniMed(r) 670G hybrid closed-loop insulin delivery system over 3 months showed a significant reduction in HbA1c levels for both adolescents and adults with type 1 diabetes.

13 Feb 2017

Long-term use of testosterone therapy in hypogonadal men may reduce risk of death from CV disease

Despite the continued controversy surrounding the use of testosterone in men who have testosterone deficiency (hypogonadism), a new study has found that long-term use of testosterone therapy not only improves vigor and vitality, but may reduce the risk of death due to cardiovascular (CV) disease.

13 Feb 2017

MSK researchers publish new review that focuses on genome-driven oncology

Researchers from Memorial Sloan Kettering Cancer Center today published a seminal review of the rapidly evolving field of precision oncology, which allows doctors to recommend therapies based on a genetic understanding of a person's cancer.

9 Feb 2017

Scientists identify vulnerabilities of highly aggressive pancreatic cancer cells

Researchers have identified a gatekeeper protein that prevents pancreatic cancer cells from transitioning into a particularly aggressive cell type and also found therapies capable of thwarting those cells when the gatekeeper is depleted.

9 Feb 2017

Smokers more likely to die from colon cancer than non-smokers, study shows

In an analysis of more than 18,000 patients treated for colon cancer, current smokers were 14 percent more likely to die from their colon cancer within five years than patients who had never smoked.

8 Feb 2017

Scientists use brain organoids to identify root causes of Miller-Dieker syndrome

Research led by scientists at UC San Francisco and Case Western Reserve University School of Medicine has used brain "organoids" — tiny 3D models of human organs that scientists grow in a dish to study disease — to identify root causes of Miller-Dieker Syndrome (MDS), a rare genetic disorder that causes fatal brain malformations.

7 Feb 2017

Study could provide novel therapeutic approach for preventing severe jaundice in newborn babies

For many newborn babies, an enzyme that breaks down the molecule bilirubin doesn't activate right away. The resulting bilirubin buildup can lead to jaundice, a typically harmless condition that causes a baby's skin to temporarily appear yellow.

6 Feb 2017

Study provides insights into functions of astrocytes following brain injury or disease

Astrocytes have long been implicated in the pathology of a range of human neurodegenerative diseases or injuries including Alzheimer's, Huntington's Parkinson's disease, brain trauma and spinal cord injury.

3 Feb 2017

GIANT study uncovers new, rare DNA changes that affect human height

In the largest, deepest search to date, the international Genetic Investigation of Anthropometric Traits Consortium has uncovered 83 new DNA changes that affect human height.

3 Feb 2017

Virginia Tech researchers receive NIH grant to improve malaria drug

As long as parasites continue to mount resistance to malaria drugs, scientists will be faced with the task of developing new, improved pharmaceuticals.

3 Feb 2017

Research unravels molecular mechanisms of antisense oligonucleotides

Stanley T. Crooke, MD, PhD, CEO of Ionis Pharmaceuticals and recipient of the 2016 Lifetime Achievement Award from the Oligonucleotide Therapeutic Society presents a detailed look at the mechanisms that underlie antisense drug activity in the article entitled "Molecular Mechanisms of Antisense Oligonucleotides," published in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers.

2 Feb 2017

Therapeutics News and Research

UC San Diego researchers receive new grant to advance malaria research

Research provides more evidence that mRNA vaccines can protect mice against Zika virus

New study confirms role of PAK4 protein in growth, spread of pancreatic cancer cells

Scientists map vast spider web of cancer proteins to reveal new drug targets

Glowing mice could mark major step forward for new gene therapy

Salk scientists use mRNA to successfully treat hemophilia B in mice

Signals from fat cells may aid in diagnostics for metabolic conditions

Research opens treatment pathways for cancers that do not respond to targeted antibodies

Penn Medicine's ODC collaborates with FAST to develop gene therapy for Angelman syndrome

Study finds reduction in HbA1c levels with in-home use of hybrid closed-loop insulin delivery system

Long-term use of testosterone therapy in hypogonadal men may reduce risk of death from CV disease

MSK researchers publish new review that focuses on genome-driven oncology

Scientists identify vulnerabilities of highly aggressive pancreatic cancer cells

Smokers more likely to die from colon cancer than non-smokers, study shows

Scientists use brain organoids to identify root causes of Miller-Dieker syndrome

Study could provide novel therapeutic approach for preventing severe jaundice in newborn babies

Study provides insights into functions of astrocytes following brain injury or disease

GIANT study uncovers new, rare DNA changes that affect human height

Virginia Tech researchers receive NIH grant to improve malaria drug

Research unravels molecular mechanisms of antisense oligonucleotides

Understanding the DNA Damage Response in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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