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Gene Therapy Contract Development and Manufacturing: Challenges and Future Perspectives

In this interview conducted at the Cell and Gene Therapy Summit Tour London, we speak to Ramin Baghirzade, Global Head of Commercial at Charles River for Gene Therapy, about the Gene Therapy CDMO solutions that Charles River Laboratories offers and more.

From Charles Rivers Laboratories Cell and Gene Therapy 18 Jul 2023

Five-year survival of children with acute lymphatic leukemia continues to increase

The five-year survival of all children with acute lymphatic leukemia (ALL) has continued to increase to 94%. This is evident from a study of 800 Dutch children. Within the study, modified treatment protocols for four subgroups were examined.

17 Jul 2023

Black patients with ICDs have higher rate of post-implant cardiac events and risk of death

Black patients with implantable cardioverter defibrillators (ICDs) have a significantly higher burden of disease than white patients with the same device, according to a new study from University of Rochester Medical Center (URMC) cardiology researchers.

17 Jul 2023

New insights into dendritic cell biology could lead to improved cancer therapies

The cells of the immune system circulate mainly in the blood and migrate into the body's tissues after an inflammation. Some types of immune cells, however, are permanently located in the tissues, where they come together to form three-dimensional networks.

17 Jul 2023

Study highlights the potential of cell replacement therapy for Huntington's disease

New research appearing in the journal Nature Biotechnology answers important questions about the viability of treatments that seek to replace diseased and aged cells in the central nervous system with healthy ones.

17 Jul 2023

Berkeley Lab and Genentech collaborate to develop new lipid nanoparticles for drug delivery

Many diseases can be successfully treated in the simple environment of a cell culture dish, but to successfully treat real people, the drug agent has to take a journey through the infinitely more complex environment within our bodies and arrive, intact, inside the affected cells.

17 Jul 2023

Three-pronged combination immunotherapy shows promise for pancreatic cancer patients

Giving patients with operable pancreatic cancers a three-pronged combination immunotherapy treatment consisting of the pancreatic cancer vaccine GVAX, the immune checkpoint therapy nivolumab and urelemab, an anti-CD137 agonist antibody treatment, is safe, it increases the amount of cancer-killing immune system T cells in the tumors and it appears effective when given two weeks prior to cancer-removal surgery, according to new research directed by Johns Hopkins investigators.

17 Jul 2023

Are antidrug antibodies reducing the effectiveness of rheumatoid arthritis treatment?

Researchers examined the association between antidrug antibodies and the response to treatments for rheumatoid arthritis.

17 Jul 2023

American Heart Association calls for more research on e-cigarettes

Research increasingly reveals health risks of e-cigarette use, and more studies are needed about the long-term impact e-cigarettes may have on the heart and lungs, according to a new scientific statement from the American Heart Association published today in the Association's flagship journal Circulation.

17 Jul 2023

New EULAR points-to-consider can help identify people at risk of psoriatic arthritis

The transition from psoriasis to PsA - and the early diagnosis of PsA - is of considerable scientific and clinical interest. People typically have psoriatic skin disease for a decade or more before they begin to experience the joint involvement of PsA.

17 Jul 2023

New agreement to facilitate genetic diagnosis of hereditary retinal dystrophies

An agreement between the University of Barcelona spin-off DBGen Ocular Genomics and the company Novartis España will enable the genetic identification of retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA) in affected patients.

17 Jul 2023

New method improves prediction of liver disease progression

A research team from the Department of Medicine III at MedUni Vienna and University Hospital Vienna has conducted a large-scale study showing the important value of repeated liver assessments by a novel method that can significantly improve risk assessment in patients with chronic liver disease.

17 Jul 2023

Touching lives: understanding factors for successful touch interventions

Researchers aimed to understand the impact of touch interventions on mental and physical health.

17 Jul 2023

Breast cancer and MEN1: exploring the connection

Researchers evaluated the role of Multiple Endocrine Neoplasia 1 (MEN1) messenger ribonucleic acid (mRNA) in breast cancer

17 Jul 2023

Innovative mixed reality training platform to be developed for pharmaceutical companies and healthcare

UK immersive technology company FourPlus, along with collaborators Holosphere and the Cell and Gene Therapy Catapult, have been awarded funding from Innovate UK to create and test a mixed reality training platform that enables customised training delivery for pharmaceutical companies and healthcare.

17 Jul 2023

Stable nanoparticles train the immune system to fight cancer

Over the past decade, researchers have sought more effective and enduring cancer treatments. Among the wide variety of immunotherapies, Stimulator of Interfron Genes activation (STING agonism) has emerged as a particularly promising approach that harnesses a patient’s immune system to combat tumors throughout the body.

17 Jul 2023

Study describes the scope and integration of music therapy program within UH medical centers

A new study from University Hospitals (UH) Connor Whole Health describes the scope and integration of their music therapy program within10 UH medical centers.

14 Jul 2023

Fungal infections: A rare but important cause of chronic sinusitis

A new research perspective was published in Oncoscience (Volume 10) on May 27, 2023, entitled, "Think outside the box – atypical infections in chronic sinusitis."

14 Jul 2023

Researcher receives $2.7 million grant to study lingering Lyme disease symptoms

An estimated 1,200 Americans, on average, are diagnosed with Lyme disease each day. Some of those patients continue to experience negative effects, even after treatment.

14 Jul 2023

New lipid 'signature' could help identify women at risk of preeclampsia

University of Virginia School of Medicine researchers have discovered a way to identify pregnant women at risk of preeclampsia, a serious disorder characterized by high blood pressure and kidney dysfunction which can result in premature delivery, seizures and even death.

14 Jul 2023

Therapy News and Research

Gene Therapy Contract Development and Manufacturing: Challenges and Future Perspectives

Five-year survival of children with acute lymphatic leukemia continues to increase

Black patients with ICDs have higher rate of post-implant cardiac events and risk of death

New insights into dendritic cell biology could lead to improved cancer therapies

Study highlights the potential of cell replacement therapy for Huntington's disease

Berkeley Lab and Genentech collaborate to develop new lipid nanoparticles for drug delivery

Three-pronged combination immunotherapy shows promise for pancreatic cancer patients

Are antidrug antibodies reducing the effectiveness of rheumatoid arthritis treatment?

American Heart Association calls for more research on e-cigarettes

New EULAR points-to-consider can help identify people at risk of psoriatic arthritis

New agreement to facilitate genetic diagnosis of hereditary retinal dystrophies

New method improves prediction of liver disease progression

Touching lives: understanding factors for successful touch interventions

Breast cancer and MEN1: exploring the connection

Innovative mixed reality training platform to be developed for pharmaceutical companies and healthcare

Stable nanoparticles train the immune system to fight cancer

Study describes the scope and integration of music therapy program within UH medical centers

Fungal infections: A rare but important cause of chronic sinusitis

Researcher receives $2.7 million grant to study lingering Lyme disease symptoms

New lipid 'signature' could help identify women at risk of preeclampsia

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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