Clinical Trial News and Research

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Study: 51% of patients alive two years after receiving CAR-T therapy for diffuse large B-cell lymphoma

A follow-up analysis of patients enrolled in a Phase I/II multi-center trial for diffuse large B-cell lymphoma reported 51 percent of patients receiving an anti-CD19 chimeric antigen receptor (CAR T) called axi-cel were still alive two years post-treatment.

3 Dec 2018

CAR T therapy can lead to long-lasting remissions in patients with r/r diffuse large B-cell lymphoma

In an update to a global clinical trial stretching from Philadelphia to four continents, the chimeric antigen receptor (CAR) T cell therapy Kymriah (tisagenlecleucel, formerly CTL019) led to long-lasting remissions in patients with relapsed/refractory (r/r) diffuse large B-cell lymphoma (DLBCL).

3 Dec 2018

Daily hydroxyurea treatment may bring some relief for African children with sickle cell anemia

A daily hydroxyurea pill may finally bring some relief for young children living with the painful and deadly blood disease sickle cell anemia in resource-challenged sub-Saharan Africa, where the disease is prevalent and health care availability is suboptimal.

3 Dec 2018

Researchers aim to develop a functional cure for HIV using therapeutic vaccines

EU-funded researchers are leading efforts to develop a functional cure for HIV using innovative therapeutic vaccines to halt the progression of the devastating virus, increase the availability and affordability of treatment, and improve patients' quality of life.

30 Nov 2018

FDA approves new combination therapy for acute myeloid leukemia

Older patients with acute myeloid leukemia (AML) often aren't healthy enough to receive intensive chemotherapy, and gentler treatments aren't very effective in treating this aggressive blood cancer.

30 Nov 2018

Controversial gene editing of embryos stopped by the Chinese authorities

The Chinese government has stopped the gene editing works of Professor He Jiankui calling it unlawful and unethical. Notably Professor Jiankui had recently claimed to have produced the world’s first pair of twins who have their genetic codes edited so that they would never be infected with HIV.

29 Nov 2018

Gel formulation of a new male contraceptive on trial

The National Institutes of Health (NIH) is funding a clinical trial to see the safety and effectiveness of a new male contraceptive that would be available in gel formulation.

29 Nov 2018

New antibody can reduce swelling attacks in patients with hereditary angioedema

Patients with hereditary angioedema experience recurrent and sometimes life-threatening swelling attacks. Researchers from Charité - Universitätsmedizin Berlin have tested an antibody capable of reducing the frequency of these swelling attacks by more than 90 percent.

28 Nov 2018

New method could improve outcome of leukemia patients receiving stem-cell transplants

Stem-cell transplantation is an effective form of therapy to fight leukemia. In many cases, however, the transferred immune cells of the donor also attack the recipients' healthy tissue - often with fatal consequences.

28 Nov 2018

Botulinum toxin injections show promise to suppress postoperative atrial fibrillation

Postoperative atrial fibrillation is a common complication, affecting one quarter to one half of all patients following cardiac surgery.

28 Nov 2018

Trial results show minimally invasive retinal detachment improves outcomes in patients

A minimally invasive treatment for retinal detachment gives patients sharper vision, less distortion and reduced side-effects, according to the findings of a randomized controlled trial performed at St. Michael's Hospital in Toronto.

27 Nov 2018

FDA grants accelerated approval to oncology drug for treatment of key genetic driver of cancer

The U.S. Food and Drug Administration today granted accelerated approval to Vitrakvi (larotrectinib), a treatment for adult and pediatric patients whose cancers have a specific genetic feature (biomarker).

27 Nov 2018

Robots could help improve social skills of children with ASD

An emotionally intelligent, partially autonomous social robot could help children with autism spectrum disorder improve their social skills, according to EU-funded researchers who have been developing the next generation of robot-enhanced therapy.

26 Nov 2018

Cereset technology reduces symptoms of military-related traumatic stress, study shows

A new clinical study conducted by Wake Forest School of Medicine shows that use of a new non-invasive technology from the creators of Cereset not only reduces symptoms of military-related traumatic stress but also improves brain function.

26 Nov 2018

Brain-computer interface enables people with tetraplegia to operate tablet devices

An investigational brain-computer interface can enable people with paralysis to directly operate an off-the-shelf tablet device by thinking about making cursor movements and clicks, according to a study published November 21, 2018 in the open-access journal PLOS ONE by Paul Nuyujukian, Jose Albites-Sanabria, and Jad Saab from the BrainGate consortium, USA, and colleagues.

23 Nov 2018

Researchers successfully restore sense of vision in blind people using BVT's bionic eye

Bionic Vision Technologies Pty Ltd today announced medical researchers had successfully restored a sense of vision in four blind people with its bionic eye as part of a clinical trial in Melbourne.

22 Nov 2018

FDA approves new treatment for AML patients

The U.S. Food and Drug Administration today approved Daurismo (glasdegib) tablets to be used in combination with low-dose cytarabine (LDAC), a type of chemotherapy, for the treatment of newly-diagnosed acute myeloid leukemia (AML) in adults who are 75 years of age or older or who have other chronic health conditions or diseases (comorbidities) that may preclude the use of intensive chemotherapy.

22 Nov 2018

Brain imaging study reveals 'hot spot' for cue-reactivity in substance users

When patients with dependence on alcohol, cocaine or nicotine are shown drug cues, or images related to the substance, an area of their brain known as the medial prefrontal cortex shows increased activity, report investigators at the Medical University of South Carolina in an article published online September 7, 2018 in Translational Psychiatry.

21 Nov 2018

Stand Up to Cancer supports potential approach to more efficiently target pancreatic cancer

Research on a new way of deploying the immune system against pancreatic cancer, an exceptionally lethal cancer that has so far resisted new immunotherapies, will receive $1 million in initial funding from Stand Up to Cancer.

21 Nov 2018

Survey: Misconceptions about opioid use undermine pain control among Asian cancer patients

Misconceptions about the use of strong opioids showed to undermine optimal pain control among Asian cancer patients undergoing chemotherapy and radiotherapy according to a cross-sectional survey conducted at the Sarawak General Hospital in Malaysia.

21 Nov 2018

Clinical Trial News and Research

Study: 51% of patients alive two years after receiving CAR-T therapy for diffuse large B-cell lymphoma

CAR T therapy can lead to long-lasting remissions in patients with r/r diffuse large B-cell lymphoma

Daily hydroxyurea treatment may bring some relief for African children with sickle cell anemia

Researchers aim to develop a functional cure for HIV using therapeutic vaccines

FDA approves new combination therapy for acute myeloid leukemia

Controversial gene editing of embryos stopped by the Chinese authorities

Gel formulation of a new male contraceptive on trial

New antibody can reduce swelling attacks in patients with hereditary angioedema

New method could improve outcome of leukemia patients receiving stem-cell transplants

Botulinum toxin injections show promise to suppress postoperative atrial fibrillation

Trial results show minimally invasive retinal detachment improves outcomes in patients

FDA grants accelerated approval to oncology drug for treatment of key genetic driver of cancer

Robots could help improve social skills of children with ASD

Cereset technology reduces symptoms of military-related traumatic stress, study shows

Brain-computer interface enables people with tetraplegia to operate tablet devices

Researchers successfully restore sense of vision in blind people using BVT's bionic eye

FDA approves new treatment for AML patients

Brain imaging study reveals 'hot spot' for cue-reactivity in substance users

Stand Up to Cancer supports potential approach to more efficiently target pancreatic cancer

Survey: Misconceptions about opioid use undermine pain control among Asian cancer patients

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