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MIT biological engineers develop method to measure heme levels inside malaria parasite

The iron-containing molecule heme is necessary for life. Cells require heme to perform the chemical reactions that produce energy, among other critical tasks.

28 Feb 2017

Researchers discover promising target for treatment of leishmaniasis

Each year, about 2 million people contract leishmaniasis, a parasitic disease transmitted by the bite of a sand fly. The cutaneous form of the disease results in disfiguring skin ulcers that may take months or years to heal and in rare cases can become metastatic, causing major tissue damage.

24 Feb 2017

Novel antiviral drug can protect transplant patients against CMV infections

In a significant advance in improving the safety of donor stem cell transplants, a major clinical trial led by researchers at Dana-Farber Cancer Institute and Brigham and Women's Hospital has shown that a novel agent can protect against the most common viral infection that patients face after transplantation.

24 Feb 2017

New investigational drug may help combat antibiotic-resistant global health threat

The deadly fungus, Candida auris, which has been found in hospitals, is resistant to entire classes of antimicrobial drugs, limiting treatment options for those infected.

24 Feb 2017

Discovery of dual role played by PGK1 enzyme may indicate new therapeutic target for brain cancer

Discovery of a dual role played by the enzyme phosphoglycerate kinase 1 (PGK1) may indicate a new therapeutic target for glioblastoma, an often fatal form of brain cancer, according to researchers at The University of Texas MD Anderson Cancer Center.

24 Feb 2017

Scientists establish ‘tipping point’ molecular link between blood sugar and Alzheimer's disease

For the first time a "tipping point" molecular link between the blood sugar glucose and Alzheimer's disease has been established by scientists, who have shown that excess glucose damages a vital enzyme involved with inflammation response to the early stages of Alzheimer's.

24 Feb 2017

Cocaine use by fathers may negatively impact cognitive development in male offspring

Fathers who use cocaine at the time of conceiving a child may be putting their sons at risk of learning disabilities and memory loss.

24 Feb 2017

NSAIDs could potentially be repurposed as life-saving treatment for sepsis, research suggests

A potentially life-saving treatment for sepsis has been under our noses for decades in the non-steroidal anti-inflammatory drugs most people have in their medicine cabinets, a new University of Colorado Boulder study suggests.

23 Feb 2017

New compounds with potent anticancer activity could lessen side effects of oncological treatments

The Universitat Jaume I, the Spanish Centre for Advanced Scientific Research and the University of Pavia have patented new compounds with potent anticancer activity in breast and colon tumour cell lines that have low toxicity in healthy cells, which can dramatically decrease side effects during chemotherapy treatment.

23 Feb 2017

Scientists propose potential new treatment for Gaucher disease

Scientists propose in Nature blocking a molecule that drives inflammation and organ damage in Gaucher and maybe other lysosomal storage diseases as a possible treatment with fewer risks and lower costs than current therapies.

23 Feb 2017

Eating up to ten portions of fruit and vegetables a day may reduce disease, early death risk

A fruit and vegetable intake above five-a-day shows major benefit in reducing the chance of heart attack, stroke, cancer and early death.

23 Feb 2017

Study finds biochemical pathway that triggers regrowth of breast cancer stem cells after chemotherapy

Working with human breast cancer cells and mice, researchers at Johns Hopkins say they have identified a biochemical pathway that triggers the regrowth of breast cancer stem cells after chemotherapy.

22 Feb 2017

Scientists unravel novel protein catalysts that can direct biosynthesis of hapalindole-type alkaloids

Alkaloids are natural nitrogen-containing compounds produced by plants and microbes. These molecules, such as morphine and quinine, are important human medicines.

22 Feb 2017

Researchers find novel, non-invasive approach for diagnosis and prognosis of prostate cancer

In a new paper in Springer's Journal of Materials Science, researchers at Washington State University report a new approach for the effective capture of tumor-derived exosomes from a prostate cancer cell line.

21 Feb 2017

Research may show new ways to repress inflammation at outset

Researchers at the University of Tübingen, working with colleagues in other parts of Germany and in the United States, have identified an enzyme as a kind of biological gauge regulating inflammation in the human body.

21 Feb 2017

Long-term heavy alcohol drinking habits may prematurely age arteries, study finds

Heavy alcohol drinking habits over the years may prematurely age arteries, especially in men, putting them at an increased risk for heart disease, according to new research in Journal of the American Heart Association, the Open Access Journal of the American Heart Association/American Stroke Association.

21 Feb 2017

EPFL scientists develop new computer model for better design of allosteric drugs

EPFL scientists have created a new computer model that can help better design of allosteric drugs, which control proteins "at a distance".

21 Feb 2017

Researchers show how metabolism drives proliferation of tumor cells

The metabolic state of tumor cells contributes to signals that control the proliferation of tumor cells. Already the German biochemist and Nobel Prize laureate Otto H. Warburg observed in the 1920s that tumor cells radically change their metabolism.

20 Feb 2017

New approach could make organometallic catalysis applicable for therapy or diagnostics

A gold catalyst can be delivered to a target organ in a higher organism where it performs a chemical transformation visualized by bioimaging.

17 Feb 2017

Researchers provide insight into causes of left or right-handedness

A preference for the left or the right hand might be traced back to that asymmetry. "These results fundamentally change our understanding of the cause of hemispheric asymmetries," conclude the authors. The team report about their study in the journal eLife.

17 Feb 2017

Enzyme News and Research

MIT biological engineers develop method to measure heme levels inside malaria parasite

Researchers discover promising target for treatment of leishmaniasis

Novel antiviral drug can protect transplant patients against CMV infections

New investigational drug may help combat antibiotic-resistant global health threat

Discovery of dual role played by PGK1 enzyme may indicate new therapeutic target for brain cancer

Scientists establish ‘tipping point’ molecular link between blood sugar and Alzheimer's disease

Cocaine use by fathers may negatively impact cognitive development in male offspring

NSAIDs could potentially be repurposed as life-saving treatment for sepsis, research suggests

New compounds with potent anticancer activity could lessen side effects of oncological treatments

Scientists propose potential new treatment for Gaucher disease

Eating up to ten portions of fruit and vegetables a day may reduce disease, early death risk

Study finds biochemical pathway that triggers regrowth of breast cancer stem cells after chemotherapy

Scientists unravel novel protein catalysts that can direct biosynthesis of hapalindole-type alkaloids

Researchers find novel, non-invasive approach for diagnosis and prognosis of prostate cancer

Research may show new ways to repress inflammation at outset

Long-term heavy alcohol drinking habits may prematurely age arteries, study finds

EPFL scientists develop new computer model for better design of allosteric drugs

Researchers show how metabolism drives proliferation of tumor cells

New approach could make organometallic catalysis applicable for therapy or diagnostics

Researchers provide insight into causes of left or right-handedness

Measuring Drug-Target Residence Times with Biochemical Assays eBook

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