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DNA computer could be important step towards development of smart, 'intelligent' drugs

Researchers at Eindhoven University of Technology present a new method that should enable controlled drug delivery into the bloodstream using DNA computers.

17 Feb 2017

Scientists map vast spider web of cancer proteins to reveal new drug targets

Scientists at Winship Cancer Institute of Emory University have mapped a vast spider web of interactions between proteins in lung cancer cells, as part of an effort to reach what was considered "undruggable."

17 Feb 2017

Chronic exposure to common food additive alters nutrient absorption in small intestine

The ability of small intestine cells to absorb nutrients and act as a barrier to pathogens is "significantly decreased" after chronic exposure to nanoparticles of titanium dioxide, a common food additive found in everything from chewing gum to bread, according to research from Binghamton University, State University of New York.

17 Feb 2017

UT Southwestern scientists unravel role of PARP enzymes in major cellular activities

A component of an enzyme family linked to DNA repair, stress responses, and cancer also plays a role in enhancing or inhibiting major cellular activities under physiological conditions, new research shows.

16 Feb 2017

Canadian researchers use gene therapy to treat patient with Fabry disease

A team of Canadian physicians and researchers is believed to be the first in the world to have used gene therapy to treat a patient with Fabry disease, a rare inherited enzyme deficiency that can damage major organs and shorten lifespan.

16 Feb 2017

Two-drug combination shows promise against diabetic retinopathy in animal models

A two-drug cocktail provided better protection against diabetes-related vision loss than a single drug during testing in rat models, a team of University of Florida Health and Dutch researchers has found.

15 Feb 2017

TSRI scientists target obesity-linked protein to prevent weight gain in animal models

Scientists are working to understand the mechanisms that make weight loss so complicated. Exercise burns calories, of course, but scientists are also looking at how the body burns more energy to stay warm in cold temperatures.

15 Feb 2017

Researchers discover sulfide-responsive protein that regulates photosynthesis in purple bacteria

Recent evidence demonstrates that the origins of photosynthesis can be found in deep sea hydrothermal vents, where microbes evolved to obtain energy from ejected hydrogen sulfide and methane gases.

15 Feb 2017

Research opens treatment pathways for cancers that do not respond to targeted antibodies

By hijacking a cancer cell's own metabolism, researchers have found a way to tag and target elusive cancers with small-molecule sugars. This opens treatment pathways for cancers that are not responsive to conventional targeted antibodies, such as triple-negative breast cancer.

15 Feb 2017

Study provides new insight into causes of rare metabolic disorder

Just before Rare Disease Day 2017, a study from the Monell Center and collaborating institutions provides new insight into the causes of trimethylaminura, a genetically-transmitted metabolic disorder that leads to accumulation of a chemical that smells like rotting fish.

14 Feb 2017

Penn Medicine's ODC collaborates with FAST to develop gene therapy for Angelman syndrome

Penn Medicine's Orphan Disease Center announces a new partnership with FAST to study gene therapy approaches to treat Angelman syndrome.

14 Feb 2017

VIB-KU Leuven scientists identify new mechanism that impacts cancer growth

Scientists at VIB-KU Leuven have identified a new mechanism that impacts tumor growth. The typical lack of oxygen in tumors doesn't only stimulate proliferation, but also offsets the important role of the protein PHD2 as 'cancer cell killer'.

14 Feb 2017

Review shows lipid nanoparticles as highly promising delivery systems in gene therapy

Lipid nanoparticles (SLNs and NLCs) are regarded as highly promising systems for delivering nucleic acids in gene therapy.

14 Feb 2017

TSRI scientists describe how key molecules in the brain work together to trigger intense anxiety

In a new study, researchers at The Scripps Research Institute have described how two important molecules in the brain work together to trigger intense anxiety.

13 Feb 2017

Scientists generate new insights into intricate molecular underpinnings of ubiquitin signaling

Scientists at the University of Würzburg have generated new insights into the intricate molecular underpinnings of ubiquitin signaling. Their results may provide new avenues for cancer therapy.

13 Feb 2017

Researchers develop new method to quickly diagnose kidney damage

Researchers from Aarhus University have developed a method for diagnosing kidney damage that is both quick and precise. Once the first patients are placed in the scanner, it will not take more than 45 minutes to make a diagnosis.

9 Feb 2017

New kit for DNA library preparation released by PCR company

Bioline, The PCR Company, a whollyowned subsidiary of Meridian Bioscience, Inc., announced the expansion of the JetSeq™ DNA Library Preparation portfolio for Next Generation Sequencing (NGS) sample preparation.

9 Feb 2017

Exosome isolation using ultracentrifugation

In the outpatient clinic and lab, our research studies aim to understand biological functions of exosomes and membrane particles.

From Beckman Coulter Life Sciences - Centrifugation 9 Feb 2017

VA scientists reveal new theory on how aspirin may ward off cancer

Studies abound that point to a role for plain old aspirin in keeping deadly cancers at bay. While aspirin is not yet part of mainstream treatment for any cancer, it is recommended by the U.S. Preventive Services Task Force for certain adults to help prevent colorectal cancer.

8 Feb 2017

New ‘release and kill’ strategy may shorten treatment periods for patients with tuberculosis

Mycobacterium tuberculosis has been called "the perfect pathogen." These bacteria hijack human macrophages, persist inside the cells to evade immune destruction, and then prevent the macrophage from undergoing programmed cell death.

8 Feb 2017

Enzyme News and Research

DNA computer could be important step towards development of smart, 'intelligent' drugs

Scientists map vast spider web of cancer proteins to reveal new drug targets

Chronic exposure to common food additive alters nutrient absorption in small intestine

UT Southwestern scientists unravel role of PARP enzymes in major cellular activities

Canadian researchers use gene therapy to treat patient with Fabry disease

Two-drug combination shows promise against diabetic retinopathy in animal models

TSRI scientists target obesity-linked protein to prevent weight gain in animal models

Researchers discover sulfide-responsive protein that regulates photosynthesis in purple bacteria

Research opens treatment pathways for cancers that do not respond to targeted antibodies

Study provides new insight into causes of rare metabolic disorder

Penn Medicine's ODC collaborates with FAST to develop gene therapy for Angelman syndrome

VIB-KU Leuven scientists identify new mechanism that impacts cancer growth

Review shows lipid nanoparticles as highly promising delivery systems in gene therapy

TSRI scientists describe how key molecules in the brain work together to trigger intense anxiety

Scientists generate new insights into intricate molecular underpinnings of ubiquitin signaling

Researchers develop new method to quickly diagnose kidney damage

New kit for DNA library preparation released by PCR company

Exosome isolation using ultracentrifugation

VA scientists reveal new theory on how aspirin may ward off cancer

New ‘release and kill’ strategy may shorten treatment periods for patients with tuberculosis

Measuring Drug-Target Residence Times with Biochemical Assays eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo