Protein C News and Research

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Scientists study OAS–RNase L errors and COVID-19-associated multisystem inflammatory syndrome in children

Researchers assessed the inborn abnormalities of 2′-5′-oligoadenylate synthetase (OAS)-ribonuclease L (RNASEL) noted in coronavirus disease 2019 (COVID-19)-associated multisystem inflammatory syndrome in children (MIS-C).

23 Dec 2022

Exploring plasma and nasal antibody responses to SARS-CoV-2 infection and vaccination

Researchers evaluated plasma and nasal antibody titers responses induced by natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) vaccinations among United Kingdom (UK) residents.

23 Dec 2022

Novel mRNA-lipid nanoparticle vaccine encoding four mpox virus surface proteins generates robust immune responses against orthopoxviruses

Researchers described a messenger ribonucleic acid (mRNA)-lipid nanoparticle monkeypox vaccine encoding four conserved monkeypox virus surface proteins which induced monkeypox virus-specific immunity and elicited heterologous protection when challenged with lethal vaccinia virus.

23 Dec 2022

Hybrid immunity from mRNA vaccines and breakthrough Omicron infections induces stronger immune responses against Omicron BQ.1.1

Researchers evaluated plasma samples from individuals vaccinated with a fourth booster dose of mono- or bivalent mRNA SARS-CoV-2 vaccine to evaluate the recognition and neutralization capacity against the ancestral (D614G) strain and the Omicron BQ.1.1 subvariant.

23 Dec 2022

Beta-containing COVID-19 booster vaccine found to cross-neutralize variants in non-human primates

A new paper presents preliminary evidence that a new vaccine candidate, designed to boost immunity in already immunized individuals, and containing the adjuvanted Beta spike variant protein antigen, can induce a potent cross-neutralizing antibody response in non-human primate models that is detectable for up to three months.

23 Dec 2022

UC San Diego researchers rewrite the textbook on gene regulation

A fundamental principle of molecular biology governs how proteins are made within the cell, which happens in two stages called transcription and translation.

22 Dec 2022

COVID-19 vaccination protects people with B cell lymphoma and multiple myeloma

A recent Nature Cancer study documented that individuals with B cell lymphomas (LY) and multiple myeloma (MM) developed potent infection neutralization capabilities against several SARS-CoV-2 variants of concern (VoCs).

22 Dec 2022

Microscopy techniques reveal a trail of destruction in bone collagen caused by high energy X-rays

A team of medical researchers at Charité has analyzed damage by focused high energetic X-rays in bone samples from fish and mammals at BESSY II.

22 Dec 2022

Simple laser irradiation speeds up the detection of very small amounts of proteins

Protein detection based on antigen–antibody reaction is vital in early diagnosis of a wide range of diseases. How to effectively detect proteins, however, has frequently bedeviled researchers.

22 Dec 2022

Research serves as a platform to identify therapeutic drugs for schizophrenia

Inflammation and overactivation of the immune system in the brain can cause loss of synapses and the death of neurons, leading to neurodegenerative and psychiatric diseases.

22 Dec 2022

Phase I clinical trial of PAC-1 in patients with end-stage cancers shows promising results

A phase I clinical trial of PAC-1, a drug that spurs programmed cell death in cancer cells, found only minor side effects in patients with end-stage cancers.

22 Dec 2022

Study links NAFLD with brain deterioration and identifies a potential therapeutic target

People with liver disease caused by eating too much sugar and fat could be at increased risk of developing serious neurological conditions like depression or dementia.

22 Dec 2022

Extracellular vesicles enhance cancer immunotherapy

Nano-sized membrane bubbles known as extracellular vesicles activate the immune system in mice and seem to render their tumors sensitive to a type of immunotherapy drug called a checkpoint inhibitor.

22 Dec 2022

3D neutron tomography reveals water diffusion across the bone material

What keeps bones able to remodel themselves and stay healthy? A team from Charité Berlin has discovered clues to the key function of non-collagen protein compounds and how they help bone cells react to external load.

22 Dec 2022

Sotorasib achieves meaningful anticancer activity in patients with KRAS G12C-mutated metastatic pancreatic cancer

In the Phase I/II CodeBreaK 100 trial, the KRAS G12C inhibitor sotorasib achieved meaningful anticancer activity with an acceptable safety profile in heavily pretreated patients with KRAS G12C-mutated metastatic pancreatic cancer, according to researchers at The University of Texas MD Anderson Cancer Center.

21 Dec 2022

Protein C News and Research

Scientists study OAS–RNase L errors and COVID-19-associated multisystem inflammatory syndrome in children

Exploring plasma and nasal antibody responses to SARS-CoV-2 infection and vaccination

Novel mRNA-lipid nanoparticle vaccine encoding four mpox virus surface proteins generates robust immune responses against orthopoxviruses

Hybrid immunity from mRNA vaccines and breakthrough Omicron infections induces stronger immune responses against Omicron BQ.1.1

Beta-containing COVID-19 booster vaccine found to cross-neutralize variants in non-human primates

UC San Diego researchers rewrite the textbook on gene regulation

COVID-19 vaccination protects people with B cell lymphoma and multiple myeloma

Microscopy techniques reveal a trail of destruction in bone collagen caused by high energy X-rays

Simple laser irradiation speeds up the detection of very small amounts of proteins

Research serves as a platform to identify therapeutic drugs for schizophrenia

Phase I clinical trial of PAC-1 in patients with end-stage cancers shows promising results

Study links NAFLD with brain deterioration and identifies a potential therapeutic target

Extracellular vesicles enhance cancer immunotherapy

3D neutron tomography reveals water diffusion across the bone material

Sotorasib achieves meaningful anticancer activity in patients with KRAS G12C-mutated metastatic pancreatic cancer

T-cell immunity remains effective against SARS-CoV-2 Omicron subvariants

Mutations responsible for common inherited heart condition corrected using CRISPR-Cas9 therapy

SARS-CoV-2 and human cold coronavirus OC43 inhibit stress granule formation through Nsp15 protein

Study explores cellular alterations in six distinct neurodegenerative diseases

Study provides insights into the coordinated dance of nerve and vascular cells

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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