Therapeutics News and Research

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Drug that improves blood flow in damaged heart may be possible treatment option for TNBC

Researchers are looking at a drug once used to improve blood flow in damaged hearts in thousands of patients as a possible treatment option for triple negative breast cancer (TNBC).

6 Jan 2017

ATA releases new guidelines for diagnosis, treatment of thyroid disease during pregnancy and postpartum

New evidence-based recommendations from the American Thyroid Association provide guidance to clinicians in diagnosing and managing thyroid disease during pregnancy and the postpartum period.

6 Jan 2017

Cancers acquire resistance to immunotherapy by eliminating tumor-specific genetic mutations

Results of an initial study of tumors from patients with lung cancer or head and neck cancer suggest that the widespread acquired resistance to immunotherapy drugs known as checkpoint inhibitors may be due to the elimination of certain genetic mutations needed to enable the immune system to recognize and attack malignant cells.

6 Jan 2017

Researchers uncover reason for stent failure in diabetic patients with clogged arteries

People with any form of diabetes are at greater risk of developing cardiovascular conditions than people without the disease. Moreover, if they undergo an operation to open up a clogged artery by inserting a "stent" surgical tube, the artery is much more likely to clog up again.

4 Jan 2017

Ardelyx initiates two clinical trials to evaluate new treatment for hyperkalemia

Ardelyx, Inc., a clinical-stage company focused on enhancing the treatment of patients with gastrointestinal and cardiorenal diseases, today announced the initiation of a Phase 3 clinical trial and an onset-of-action clinical trial evaluating RDX7675 in patients with hyperkalemia, a potentially life-threatening condition common in patients with cardiorenal disease.

3 Jan 2017

AAV-based gene therapy to treat liver disorders advances into human testing

Liver-directed gene therapy delivered using adeno-associated viral (AAV) vectors to treat diseases such as hemophilia have advanced into human testing.

30 Dec 2016

Researchers create molecules with potential to deliver healing power to stressed cells

Molecules with the potential to deliver healing power to stressed cells - such as those involved in heart attacks - have been created by University of Oregon researchers.

30 Dec 2016

Study suggests new options for improving cancer immunotherapy

One of the main reasons cancer remains difficult to treat is that cancer cells have developed a multitude of mechanisms that allow them to evade destruction by the immune system.

30 Dec 2016

Nexmos, Base Pair Biotechnologies create new class of DNA-aptamer based oxidation inhibitors

Base Pair Biotechnologies, Inc., The Aptamer Discovery Company, and Nexmos, Inc., the Aptamer Application R&D Company, announce the creation of a new class of DNA-aptamer based oxidation inhibitors.

30 Dec 2016

New strategy may bring us one step closer to "fountain of youth”

It's an exciting time to be an elderly mouse. Researchers believe that by removing senescent cells (cells with a persistent damage response), which naturally accumulate with age, senior rodents can regrow hair, run faster, and improve organ function.

30 Dec 2016

Studies in non-human primates provide more predictive results in genetic causes of blindness

Many gene therapy-based approaches are in development to combat genetic and other causes of blindness and vision loss, and much can be learned about the safety and effectiveness of these promising new therapies by studying them first in non-human primates before initiating clinical trials, as shown by the results of a study published in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

29 Dec 2016

Fred Hutch’s new Evergreen Fund to promote commercialization of research into lifesaving therapies

Fred Hutchinson Cancer Research Center announced its first-ever grants from its newly established Evergreen Fund to spur researchers' efforts to advance bold ideas toward creating or partnering with a commercial entity.

28 Dec 2016

Nanodiscs deliver customized therapeutic vaccine for treatment of colon, melanoma cancers

Researchers at the University of Michigan have had initial success in mice using nanodiscs to deliver a customized therapeutic vaccine for the treatment of colon and melanoma cancer tumors.

27 Dec 2016

Novel investigational drug may help restore cardiac function after heart failure

Cimaglermin, a new experimental drug, may help restore cardiac function after heart failure, according to a first-in-man study published today in JACC: Basic to Translational Science.

27 Dec 2016

New discovery could lead to effective drugs to prevent excessive lymphatic growth in cancer

Cancer cells spread to other sites in the body through promoting the growth of new 'roads' to travel on.

27 Dec 2016

Ionis announces FDA approval of first SMA drug in the U.S for pediatric and adult patients

Ionis Pharmaceuticals, Inc. announced today that the U.S. Food and Drug Administration has approved SPINRAZATM (nusinersen) under Priority Review for the treatment of spinal muscular atrophy (SMA) in pediatric and adult patients.

26 Dec 2016

TSRI scientists shed light on how antiviral drug stops influenza infections

A new study led by scientists at The Scripps Research Institute (TSRI) is the first to show exactly how the drug Arbidol stops influenza infections. The research reveals that Arbidol stops the virus from entering host cells by binding within a recessed pocket on the virus.

22 Dec 2016

UF Health researchers elucidate how some tumors bolster own blood supply

As cancerous tumors fester in the body, they need an ever-increasing blood supply to deliver the oxygen and nutrients that fuel their growth. Now, a team led by University of Florida Health researchers has established how some tumors bolster their own blood supply.

22 Dec 2016

Wellcome Trust Sanger Institute establishes spin-out company, Microbiotica

Cambridge Innovation Capital plc, a Cambridge-based investor in technology and healthcare companies, and IP Group plc, the developer of intellectual property-based businesses, announce the creation of Microbiotica Ltd, a newly formed spin-out company from the UK’s Wellcome Trust Sanger Institute based at the Wellcome Genome Campus in Hinxton, Cambridge.

21 Dec 2016

Breast cancer patient finds new hope with potentially revolutionary treatment

City of Hope patient Susan Young has had a remarkable response to a potentially revolutionary new treatment, a combination of the p53 cancer vaccine and a drug that blocks a specific cancer-aiding protein.

21 Dec 2016

Therapeutics News and Research

Drug that improves blood flow in damaged heart may be possible treatment option for TNBC

ATA releases new guidelines for diagnosis, treatment of thyroid disease during pregnancy and postpartum

Cancers acquire resistance to immunotherapy by eliminating tumor-specific genetic mutations

Researchers uncover reason for stent failure in diabetic patients with clogged arteries

Ardelyx initiates two clinical trials to evaluate new treatment for hyperkalemia

AAV-based gene therapy to treat liver disorders advances into human testing

Researchers create molecules with potential to deliver healing power to stressed cells

Study suggests new options for improving cancer immunotherapy

Nexmos, Base Pair Biotechnologies create new class of DNA-aptamer based oxidation inhibitors

New strategy may bring us one step closer to "fountain of youth”

Studies in non-human primates provide more predictive results in genetic causes of blindness

Fred Hutch’s new Evergreen Fund to promote commercialization of research into lifesaving therapies

Nanodiscs deliver customized therapeutic vaccine for treatment of colon, melanoma cancers

Novel investigational drug may help restore cardiac function after heart failure

New discovery could lead to effective drugs to prevent excessive lymphatic growth in cancer

Ionis announces FDA approval of first SMA drug in the U.S for pediatric and adult patients

TSRI scientists shed light on how antiviral drug stops influenza infections

UF Health researchers elucidate how some tumors bolster own blood supply

Wellcome Trust Sanger Institute establishes spin-out company, Microbiotica

Breast cancer patient finds new hope with potentially revolutionary treatment

Understanding the DNA Damage Response in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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