Clinical Trial News and Research

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Physician-scientists treat first patient in the U.S. with focused ultrasound for neuropathic leg pain

University of Maryland physician-scientists have treated the first patient in the United States with MRI-guided focused ultrasound for neuropathic leg pain as part of a pilot clinical trial.

30 Oct 2018

Patients receiving individual doses and conventional breast radiation experience similar side effects

In a 10-year study of women who received radiation therapy to treat early-stage breast cancer, those receiving fewer, larger individual doses experienced similarly low rates of late-onset side effects as those undergoing conventional radiation therapy. Findings from the multi-institutional U.K. FAST clinical trial were presented last week at the 60th Annual Meeting of the American Society for Radiation Oncology.

30 Oct 2018

Radiation therapy can lower risk of breast cancer recurrence in patients with ‘good risk’ DCIS

A subset of patients with low-risk breast cancer is highly unlikely to see cancer return following breast conservation surgery but can lower that risk even further with radiation therapy, finds a new long-term clinical trial report.

30 Oct 2018

Neuroene Therapeutics receives $1.5 million NIH grant to develop anti-seizure compound for epilepsy

Neuroene Therapeutics, a start-up company founded by mitochondrial biologist Sherine S. L. Chan, Ph.D. and medicinal chemist C. James Chou, Ph.D. of the Medical University of South Carolina, has received a $1.5 million NIH Phase II Small Business Innovation Research grant to optimize vitamin K analogues that could improve seizure control in patients with drug-resistant epilepsy.

29 Oct 2018

Researchers receive grant to study treatment options for binge eating disorder in veterans

For the first time, the United States Department of Defense has awarded a grant to researchers at University of California San Diego School of Medicine to study binge eating disorder treatments in veterans and active duty military.

29 Oct 2018

Hormone injections reduce risk for early menopause from breast cancer chemotherapy

Final results of SWOG Cancer Research Network's groundbreaking international Prevention of Early Menopause Study clinical trial are in, and they show continued evidence that women who get injections of the hormone drug goserelin along with standard breast cancer chemotherapy are more likely to become pregnant - without developing negative side effects or shortening their lives.

29 Oct 2018

TherapeuticsMD announces FDA approval of BIJUVA capsules to manage vasomotor symptoms of menopause

TherapeuticsMD, Inc., an innovative women's healthcare company, today announced that the United States Food and Drug Administration has approved BIJUVA (estradiol and progesterone) capsules, 1 mg/100 mg, the first and only FDA-approved bio-identical hormone therapy combination of estradiol and progesterone in a single, oral capsule for the treatment of moderate to severe vasomotor symptoms (commonly known as hot flashes or flushes) due to menopause in women with a uterus.

29 Oct 2018

Novartis enters into clinical development agreement with Pfizer to improve treatment of NASH

Novartis announced today that it has entered into a clinical development agreement with Pfizer which will include a study combining tropifexor and one or more Pfizer compounds for the treatment of NASH, including an Acetyl CoA-Carboxylase (ACC) Inhibitor (PF-05221304, a Diacylglycerol O-Acyltransferase 2 (DGAT2) Inhibitor (PF-06865571, and a Ketohexokinase (KHK) Inhibitor (PF-06835919).

29 Oct 2018

High-impact clinical trial results could affect kidney-related medical care

The results of numerous high-impact clinical trials that could affect kidney-related medical care will be presented at ASN Kidney Week 2018 October 23-October 28 at the San Diego Convention Center.

26 Oct 2018

Quadrant Biosciences announces collaboration on research into treatment of ASD

Quadrant Biosciences, Inc., an emerging life science company based in Syracuse, N.Y., today announced its collaboration with the Autism Speaks® Autism Treatment Network and its university research partners on research into the treatment of autism spectrum disorder.

26 Oct 2018

Active ingredient in magic mushrooms could soon become a depression treatment

The active ingredient in magic mushrooms is psilocybin. Psilocybin is a naturally occurring psychedelic prodrug compound produced by more than 200 species of mushroom and is the reason behind the “high” provided by the magic mushrooms. Now, Psilocybin may soon achieve legal status to be used for treatment of difficult to treat depressive illness.

26 Oct 2018

The Lancet Infectious Diseases journal publishes clinical trial results for Shionogi’s cefiderocol

Shionogi & Co., Ltd. announced today that The Lancet Infectious Diseases journal has published clinical results from the pivotal randomized controlled trial evaluating cefiderocol for the treatment of complicated urinary tract infection in patients at risk of multidrug-resistant Gram-negative infections.

26 Oct 2018

Novel drug extends survival for women with HR-positive metastatic breast cancer

The drug palbociclib, used in combination with standard treatment, improved survival for women with hormone receptor-positive metastatic breast cancer, according to a large phase III clinical trial.

24 Oct 2018

SBRT found to be safe treatment for patients with multiple metastases

The NRG Oncology clinical trial BR001 tested the hypothesis that stereotactic body radiotherapy could be used safely in oligometastatic patients with multiple metastases.

24 Oct 2018

Hippocampal avoidance during whole-brain radiotherapy reduces risk of cognitive decline

Whole-brain radiotherapy can be delivered more safely to patients with brain metastases by avoiding the hippocampus according to a randomized phase III NRG Oncology trial presented at the American Society for Radiation Oncology Annual Meeting.

23 Oct 2018

Lowering systolic blood pressure does not damage the kidneys, shows study

Using a novel biomarker panel to track and measure kidney function, researchers at University of California San Diego School of Medicine and University of California San Francisco School of Medicine report that lowering systolic blood pressure to less than 120 mm Hg does not damage the kidney organ itself.

23 Oct 2018

Polyganics begins first-in-human clinical trial of LIQOSEAL for reducing CSF leakage

Polyganics today announced that it has initiated enrollment of patients into a first-in-human clinical trial of LIQOSEAL, its dura sealant patch.

23 Oct 2018

Advanced breast cancer patients can benefit from immunotherapy-chemotherapy combination

Patients with an aggressive form of advanced breast cancer can benefit from immunotherapy when used in combination with chemotherapy as first-line treatment, according to the results of a large international Phase III clinical trial published today in the New England Journal of Medicine and led by a researcher at the UPMC Hillman Cancer Center and the University of Pittsburgh School of Medicine.

23 Oct 2018

Study reveals new treatment option for women with advanced breast cancer resistant to hormone therapy

Treatment with the cyclin dependent kinase 4/6 inhibitor palbociclib achieves a clinically meaningful improvement in overall survival in patients with hormone receptor positive human epidermal growth factor receptor-2 negative advanced breast cancer that has relapsed or progressed on hormonal therapy, according to the final analysis of overall survival results from the PALOMA-3 study reported at ESMO 2018.

23 Oct 2018

Drugs approved for breast cancer treatment are effective and well tolerated in men

There is growing evidence that drugs approved for the treatment of breast cancer in women are also effective and well tolerated in men, according to the largest real-life study yet to investigate treatment and outcomes in men with breast cancer and two further studies to be reported at ESMO 2018.

23 Oct 2018

Clinical Trial News and Research

Physician-scientists treat first patient in the U.S. with focused ultrasound for neuropathic leg pain

Patients receiving individual doses and conventional breast radiation experience similar side effects

Radiation therapy can lower risk of breast cancer recurrence in patients with ‘good risk’ DCIS

Neuroene Therapeutics receives $1.5 million NIH grant to develop anti-seizure compound for epilepsy

Researchers receive grant to study treatment options for binge eating disorder in veterans

Hormone injections reduce risk for early menopause from breast cancer chemotherapy

TherapeuticsMD announces FDA approval of BIJUVA capsules to manage vasomotor symptoms of menopause

Novartis enters into clinical development agreement with Pfizer to improve treatment of NASH

High-impact clinical trial results could affect kidney-related medical care

Quadrant Biosciences announces collaboration on research into treatment of ASD

Active ingredient in magic mushrooms could soon become a depression treatment

The Lancet Infectious Diseases journal publishes clinical trial results for Shionogi’s cefiderocol

Novel drug extends survival for women with HR-positive metastatic breast cancer

SBRT found to be safe treatment for patients with multiple metastases

Hippocampal avoidance during whole-brain radiotherapy reduces risk of cognitive decline

Lowering systolic blood pressure does not damage the kidneys, shows study

Polyganics begins first-in-human clinical trial of LIQOSEAL for reducing CSF leakage

Advanced breast cancer patients can benefit from immunotherapy-chemotherapy combination

Study reveals new treatment option for women with advanced breast cancer resistant to hormone therapy

Drugs approved for breast cancer treatment are effective and well tolerated in men

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