Genomic News and Research

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Researchers expose the biology of Clostridium difficile transmission in mice

New research suggests that antibiotic treatment could be asymptomatically inducing the transmission of the healthcare-acquired infection, C. difficile, contributing to the outbreaks that have recently been widely reported in hospitals and other settings. A team of scientists have successfully mirrored the infection cycle of C. difficile by generating a 'mouse hospital' with conditions mimicking the human environment in which C. difficile is transmitted.

20 Jul 2009

Discovery of five genetic variants related to blood pressure in African-Americans

A team led by researchers from the National Institutes of Health (NIH) has reported the discovery of five genetic variants related to blood pressure in African-Americans, findings that may provide new clues to treating and preventing hypertension. The effort marks the first time that a relatively new research approach, called a genome-wide association study, has focused on blood pressure and hypertension in an African-American population.

17 Jul 2009

New research tool – map of genomic variation for diagnosing and identifying genetic problems

Genetics researchers have unveiled a powerful new resource for scientists and health providers studying human illnesses -- a reference standard of deletions and duplications of DNA found in the human genome. Drawn from over 2,000 healthy persons, the study provides one of the deepest and broadest sets of copy number variations (CNVs) available to date, along with a new research tool for diagnosing and identifying genetic problems in patients.

15 Jul 2009

New UK national genome centre

A new UK national genome centre was officially opened by Nobel Laureate and genome pioneer Prof Sir John Sulston and the Lord-Lieutenant of Norfolk.

5 Jul 2009

Discovery of new gene associated with diabetes

Research led by the German Institute of Human Nutrition (DIfE) has identified a new gene associated with diabetes, together with a mechanism that makes obese mice less susceptible to diabetes.

5 Jul 2009

Drink milk to lose weight!

According to the latest research milk helps satisfy hunger by making people feel full and could be useful in weight loss.

2 Jul 2009

The Virtual Physiological Human

It could mean the end of animal testing and eventually even clinical patient drug trials. The Virtual Physiological Human is a 21st century pan-European project that’s gaining momentum and takes a major step forward this week at The University of Nottingham.

29 Jun 2009

New, less invasive genetic test greatly improves pregnancy rates in older women with poor prognosis

A new test examining chromosomes in human eggs a few hours after fertilisation can identify those that are capable of forming a healthy baby, a researcher told the 25th annual conference of the European Society of Human Reproduction and Embryology today (Monday 29 June).

29 Jun 2009

DNA template could explain evolutionary shifts

Rearrangements of all sizes in genomes, genes and exons can result from a glitch in DNA copying that occurs when the process stalls at a critical point and then shifts to a different genetic template, duplicating and even triplicating genes or just shuffling or deleting part of the code within them, said researchers from Baylor College of Medicine in a recent report in the journal Nature Genetics.

22 Jun 2009

Researchers develop promising new breast cancer diagnostic marker

Indiana University School of Medicine researchers have developed a new breast cancer diagnostic marker that could enable physicians to more easily determine which patients have a less aggressive form of the disease that may not require chemotherapy treatment.

21 Jun 2009

Targeting tumor behavior may find new anti-cancer agents

Ohio State University cancer researchers have used computational and genomic methods to identify possible anti-cancer agents that may block a particular kind of tumor behavior. The agents target multiple genes associated with that behavior at one time.

18 Jun 2009

Genomic discovery: Protecting kidney function during heart failure

Mayo Clinic cardiology researchers have found a peptide that helps preserve and improve kidney function during heart failure, without affecting blood pressure. Earlier variations of this peptide caused blood pressure to drop limiting the potential benefits to the kidneys. The findings appear in the current Proceedings of the National Academy of Sciences.

16 Jun 2009

Don't stress when the going gets tough - you'll go gray!

A study by Japanese researchers has revealed that a certain kind of stress damages the hair - they say "genotoxic stress" damages DNA by depleting the melanocyte stem cells (MSCs) within hair follicles that are responsible for making the pigment-producing cells.

14 Jun 2009

Genotoxic stress makes your hair go gray

Those pesky graying hairs that tend to crop up with age really are signs of stress, reveals a new report in the June 12 issue of Cell, a Cell Press publication.

12 Jun 2009

51 genes predict breast cancer survival

It may be possible in the future to use a specimen from the tumour to determine which patients with breast cancer have a good chance of overcoming the disease, and which patients should be given more intensive treatments.

10 Jun 2009

Study gives clues to how ultra-rare adrenocortical cancer forms

At the ends of chromosome are special pieces of DNA called telomeres. Think of it as the little tip that caps off a shoelace. The telomeres send signals to the cells to let them know it's the end point, not a break that should be repaired.

4 Jun 2009

Oxidative stress strongly evident in the in-utero environment of the fetus with Down syndrome

A paper published in the Proceedings of the National Academy of Sciences by Tufts Medical Center and Tufts University researchers reports that amniotic fluid surrounding Down syndrome fetuses shows oxidative stress, a condition that could harm fetal cells and play a role in affected individuals. The results demonstrate secondary adverse consequences of Down syndrome and suggest potential prenatal therapies.

2 Jun 2009

Genomic research lays groundwork for new approaches for treating, preventing skin diseases

The health of our skin - one of the body's first lines of defense against illness and injury - depends upon the delicate balance between our own cells and the millions of bacteria and other one-celled microbes that live on its surface.

28 May 2009

Research may lead to improved TB vaccines

A team of Vanderbilt University Medical Center investigators has cracked one of clinical medicine's enduring mysteries - what happened to the tuberculosis vaccine. The once-effective vaccine no longer prevents the bacterial lung infection that kills more than 1.7 million people worldwide each year.

19 May 2009

Oxford BioTherapeutics and GSK form alliance to develop cancer therapeutic antibodies

Oxford BioTherapeutics (OBT) today announced a strategic alliance with GlaxoSmithKline to discover, develop and commercialise novel, therapeutic antibodies for the treatment of primary, metastatic and recurring forms of cancer.

18 May 2009