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New trial aims to make rectal cancer more responsive to radiation

City of Hope, one of the largest and most advanced cancer research and treatment organizations in the U.S. with its National Medical Center named top 5 in the nation for cancer by U.S. News & World Report, has opened a phase 1 trial seeking to one day transform rectal cancer from a mostly radiation-resistant disease to one that can be cured using radiation and chemotherapy.

25 Mar 2025

Scientists develop universal vaccine targeting multiple coronaviruses

Sugar coatings aren't only for candies; they also help viruses, like the ones that cause COVID-19, hide from their hosts' immune system.

25 Mar 2025

UZH researchers develop decoy molecules to restore immune defense

An immune system defect makes affected individuals vulnerable to severe viral diseases such as influenza or COVID-19. It is caused by the body's own antibodies, which inhibit important defense proteins known as type I interferons.

24 Mar 2025

Researchers develop tool to enhance NK cells against cancer

A team of researchers from the Hospital del Mar Research Institute, the Universitat Autònoma de Barcelona and the Pompeu Fabra University has developed a new tool that allows modifying these NK cells to make them immune to the tumor’s defense mechanism.

24 Mar 2025

New monoclonal antibody shows promise in treating mucormycosis

Mucormycosis, a fungal infection caused by Mucorales, has high mortality rates in people with weakened immune systems and those suffering from severe trauma like burns, blast injuries or victims of natural disasters.

22 Mar 2025

Asgard archaea provide clues to the origin of complex life forms

Ten years ago, nobody knew that Asgard archaea even existed. In 2015, however, researchers examining deep-sea sediments discovered gene fragments that indicated a new and previously undiscovered form of microbes.

22 Mar 2025

Scientists discover irreversible peptide inhibitors for undruggable cancer target

For the first time scientists have identified promising drug candidates that bind irreversibly with a notoriously "undruggable" cancer protein target, permanently blocking it.

20 Mar 2025

Study reveals how B cells safeguard high-affinity antibodies

A vaccine's ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a vaccine or pathogen, B cells scramble to refine their defenses, rapidly mutating in hopes of generating the most effective antibodies.

19 Mar 2025

Research findings solve the paradox of how the immune system balances speed and precision

Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted to keep different pathogens in check.

19 Mar 2025

Clinical trial investigates osteoporosis medication for type 1 diabetes

City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the United States and a top research center for diabetes and other life-threatening illnesses, is leading a phase 1/2 clinical trial investigating an osteoporosis medication as a way to improve beta cell health in people with early type 1 diabetes.

19 Mar 2025

UZH researchers develop technology to test 25 antibodies in a single mouse

New active ingredients such as antibodies are usually tested individually in laboratory animals. Researchers at UZH have now developed a technology that can be used to test around 25 antibodies simultaneously in a single mouse.

18 Mar 2025

ASCOLT trial explores aspirin’s role in preventing colorectal cancer recurrence

A large-scale, international, multicentre, phase 3 clinical trial of aspirin for the secondary prevention of colorectal cancer has concluded.

17 Mar 2025

Baked eggs in infancy may lower lifelong egg allergy risk

Introducing baked eggs to infants aged 4–6 months and maintaining daily intake for six months significantly improves tolerance to cooked eggs, reducing the risk of egg allergy.

17 Mar 2025

Breakthrough peptide inhibitor effective against multiple SARS-CoV-2 variants

SARS-CoV-2, the virus responsible for COVID-19, infects cells by binding its spike protein to angiotensin-converting enzyme 2 (ACE2) receptors.

14 Mar 2025

Long-COVID symptoms persist for two years in over half of cases

23% of people infected with SARS-CoV-2 between 2021 and 2023 developed long-COVID, and in more than half of them the symptoms persisted for two years.

14 Mar 2025

Study unveils mechanisms behind antigenic variation in pathogens

A new study by LMU and Helmholtz Munich shows how pathogens control changes in their cell surface to evade the immune system.

14 Mar 2025

Older adults may have stronger immunity to bird flu, Penn study finds

Prior exposures to specific types of seasonal influenza viruses promote cross-reactive immunity against the H5N1 avian influenza virus, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

13 Mar 2025

Scientists reveal how Epstein-Barr virus reactivation triggers MIS-C in children

Scientists reveal that reactivation of Epstein-Barr virus (EBV), driven by TGFβ-induced immune suppression, is a key driver of multisystem inflammatory syndrome in children (MIS-C) following COVID-19. Blocking TGFβ may offer a potential new treatment for this life-threatening condition.

13 Mar 2025

Gut microbiota impacts pneumococcal vaccine response in immunodeficient individuals

Gut microbiota may be the key factor explaining why certain individuals do not respond well to the pneumococcal vaccine-a bacterium that can cause various diseases, such as pneumonia.

13 Mar 2025

IgE antibodies show promise in targeting HER2 cancers resistant to other therapies

Antibody treatment which activates the patient's own immune system against cancer, known as immunotherapy, is increasingly being investigated as an alternative for chemotherapy and radiotherapy.

12 Mar 2025