Biochemistry News and Research

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Unlocking the secrets of our "dark genome": Scientists crack the code of LINE-1

A multidisciplinary study published in Nature has elucidated the structure of the machinery responsible for writing much of our "dark genome" - the 98 percent of our DNA that has largely unknown biological function.

14 Dec 2023

Researchers unveil new way to sensitize resistant tumors to treatment

Resistance to therapies is one of the obstacles to overcome in cancer treatments. Understanding the mechanisms of this resistance is essential to design strategies that favor tumor cell death.

14 Dec 2023

Immunopeptidomics offer new hope in cancer research

In this new omg OMx podcast episode, Bruker's Kate Stumpo speaks to Nicola Ternette on the incredible world of immunopeptidomics - the implications they could have for research and how they help us understand the immune system better.

From Bruker Daltonics 13 Dec 2023

UVA atlas unveils cellular blueprint of atherosclerosis

University of Virginia School of Medicine researchers have created an "atlas of atherosclerosis" that reveals, at the level of individual cells, critical processes responsible for forming the harmful plaque buildup that causes heart attacks, strokes and coronary artery disease.

12 Dec 2023

UB research identifies key mechanism in infantile cystinosis

University at Buffalo research has identified how a misstep in the genesis of a key component of the kidney causes infantile cystinosis, a rare disease that significantly shortens the lifespan of patients.

11 Dec 2023

New drug combo shows promise in targeting RAS-mutant multiple myeloma

The combination of a drug and a protein fragment prevents the growth of blood cancer cells, a new study in mice shows.

11 Dec 2023

Study unlock secrets of Zika virus's multipurpose enzyme and reveals therapeutic vulnerability

Viruses have limited genetic material - and few proteins - so all the pieces must work extra hard. Zika is a great example; the virus only produces 10 proteins.

8 Dec 2023

Vanderbilt's potential schizophrenia treatment enters phase 1 clinical trials

A potential schizophrenia treatment discovered through the Warren Center for Neuroscience Drug Discovery has been cleared by the U.S. Food and Drug Administration for use in phase 1 clinical trials - the third WCNDD therapeutic to reach that benchmark.

7 Dec 2023

The past, present and future of automation and digitalization in the life sciences laboratory

In this interview, News-Medical talks to Dr. Klaus Lun and Chris Mason about the past, present and future of automation and digitalization in the life sciences laboratory and especially the impact this could have on next-generation sequencing and genomics.

From Tecan 5 Dec 2023

New insights into the interplay between prions and TDP-43 in neurodegenerative pathology

Neurodegenerative diseases are characterized by the deposition of clumped proteins in the brain and progressive neuronal cell death.

4 Dec 2023

Scientists uncover new mechanism by which leukemia cells exploit cellular recycling process

In a recent study, scientists led by Professor Stefan Müller from Goethe University's Institute of Biochemistry II investigated a specific form of blood cancer known as acute myeloid leukemia, or AML.

4 Dec 2023

New drug combination may improve treatment for rare nerve sheath tumors

Combining a pair of experimental drugs may help treat malignant peripheral nerve sheath tumors with fewer harmful side effects, according to preliminary animal studies led by investigators at the Johns Hopkins Kimmel Cancer Center and Johns Hopkins Drug Discovery.

1 Dec 2023

Scientists uncover cellular cause of heart defects in babies born to women with diabetes

When women with diabetes become pregnant, they face not only the typical challenges of pregnancy and impending parenthood, but also a scary statistic: they're five times more likely to have a baby with a congenital heart defect.

30 Nov 2023

Collaborative study focuses on understanding the strength of adhesion of COVID-19 variants

A recent groundbreaking study, published in Nature Nanotechnology, sheds new light on the coronavirus's behavior, particularly its ability to remain attached under various mechanical stresses and the implications for person-to-person transmission.

29 Nov 2023

Study unravels how bacterial vaginosis disrupts vaginal health

Bacterial vaginosis is a common condition in which the natural microbiome of the vagina falls out of balance, sometimes leading to complications in sexual and reproductive health.

29 Nov 2023

Researchers discover new gene targets for precision oncology in esophageal cancer

Researchers have identified a new way to screen genes that cause several different types of cancers to grow, identifying particularly promising targets for precision oncology in oral and esophageal squamous cancers.

28 Nov 2023

JMU Würzburg professor wins ERC Consolidator Grant to advance research on ferroptosis

With the coveted Consolidator Grants totalling two million euros, the European Research Council (ERC) supports outstanding scientists whose work promises further top achievements. José Pedro Friedmann Angeli, Professor of Translational Cell Biology at Rudolf Virchow Centre - Centre for Integrative and Translational Bioimaging at Julius-Maximilians-Universität (JMU) Würzburg, now belongs to this group.

23 Nov 2023

Researchers discover mechanism for memory storage in engram cells

What is the mechanism that allows our brains to incorporate new information about the world, and form memories? New work by a team of neuroscientists led by Dr Tomás Ryan from Trinity College Dublin shows that learning occurs through the continuous formation of new connectivity patterns between specific engram cells in different regions of the brain.

22 Nov 2023

New treatment for neurodegenerative diseases may be found in used coffee grounds

Neurodegenerative disorders, including Alzheimer's, Parkinson's and Huntington's, affect millions of people in the United States, and the cost of caring for people who live with these conditions adds up to hundreds of billions of dollars each year.

21 Nov 2023

Uncontrolled growth as a cancer cell's weakness

Growth is a fundamental biological process and a prerequisite for living organisms to develop and reproduce. The processes of cell growth (i.e. the production of new biomass) and of cell division must be coordinated with each other.

17 Nov 2023