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Pfizer COVID-19 vaccine elicits durable specific memory T-cell response

A new preprint describes the protective efficacy of memory T-cells developed in response to the viral antigen, which could offer long-term immunity.

4 Nov 2021

Novel model-based framework evaluates immune mechanism of COVID-19 vaccine response

A model framework for characterizing viral dynamics and vaccine efficacy in non-human primates is described and applied to the identification of correlates of protection in three independent vaccine studies.

4 Nov 2021

Adaptive immunity in patients infected with SARS-CoV-2 Δ382 Variant

A comprehensive characterization of the immune responses between SARS-CoV-2 infected individuals with wildtype (WT) and Δ382 SARS-CoV-2.

3 Nov 2021

How long does natural or vaccine-induced immunity to COVID last?

Researchers present a comprehensive assessment on SARS-CoV-2 induced immunity.

28 Oct 2021

A novel approach to improve the stability of Remdesivir

A recent study discusses a novel method to enhance the stability of Remdesivir.

28 Oct 2021

Immunogenicity and efficacy of heterologous ChadOx1/BNT162b2 vaccination amongst healthcare workers

The heterologous ChAd/BNT combination confers better protection against SARS-CoV-2 infection than the homologous BNT/BNT combination in a real-world observational study of healthcare workers.

27 Oct 2021

Role of SARS-CoV-2 infection biomarkers in HIV replication

A new study investigates the role of the S100A8/A9 complex in the replication of HIV.

25 Oct 2021

Study shows immune profile heterogeneity amongst healthy adults

Researchers opted to use single-cell RNA-seq to observe single cells in detail as they encounter a specific antigen.

22 Oct 2021

Novel Einstein-developed strategy successfully suppresses HIV infections in mice

Armed with a novel strategy they developed for bolstering the body's immune response, scientists at Albert Einstein College of Medicine have successfully suppressed HIV infections in mice - offering a path to a functional cure for HIV and other chronic viral infections.

21 Oct 2021

Children show lower seroconversion rates than adults with mild COVID-19

A new study finds that following mild COVID-19, children are more likely to remain seronegative than adults, irrespective of the viral load or symptom severity.

20 Oct 2021

Many people's T-cells recognize the same components of SARS-CoV-2

A new study published on the bioRxiv* preprint aimed to identify highly immunoprevalent CD8 T-cell epitopes specific to SARS-CoV-2 that are confirmed to be endogenously processed and presented on frequently expressed HLA alleles.

18 Oct 2021

Research indicates that mRNA vaccine-induced T cells respond robustly to new SARS-CoV-2 variants

To address the gaps in the knowledge, a team of researchers from the University of California and the Gladstone Institute of Virology conducted 39-parameter phenotyping by cytometry by time of flight (CyTOF) on 33 longitudinal specimens from 11 mRNA-vaccinated individuals, of which six had previously been infected and recovered from COVID-19.

18 Oct 2021

CD4 News and Research

Pfizer COVID-19 vaccine elicits durable specific memory T-cell response

Novel model-based framework evaluates immune mechanism of COVID-19 vaccine response

Adaptive immunity in patients infected with SARS-CoV-2 Δ382 Variant

How long does natural or vaccine-induced immunity to COVID last?

A novel approach to improve the stability of Remdesivir

Immunogenicity and efficacy of heterologous ChadOx1/BNT162b2 vaccination amongst healthcare workers

Role of SARS-CoV-2 infection biomarkers in HIV replication

Study shows immune profile heterogeneity amongst healthy adults

Novel Einstein-developed strategy successfully suppresses HIV infections in mice

Children show lower seroconversion rates than adults with mild COVID-19

Many people's T-cells recognize the same components of SARS-CoV-2

Research indicates that mRNA vaccine-induced T cells respond robustly to new SARS-CoV-2 variants

Metabolic restoration as a therapeutic approach to promote natural immune protection against HIV

Phase 1 open-label trial shows SARS-CoV-2 DNA vaccine induces durable immune response

SARS-CoV-2 induces tissue immune memory

COVID-19 vaccination induces transient increase in cellular and antibody responses to S1 antigenic sequence

SARS-CoV-2 immune responses in nursing home residents after full vaccination with Pfizer-BioNTech COVID-19 vaccine

Critical function of IL-7 in diagnosis, prognosis, and treatment of COVID-19 patients

Gene expression changes during acute SARS-CoV-2 infection may decide long-COVID symptoms

Anti-CD20 therapy patients can develop immune responses after SARS-CoV-2 vaccination

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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