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Promising molecule could stop or slow Parkinson’s

A promising molecule has offered hope for a new treatment that could stop or slow Parkinson’s, something no treatment can currently do.

14 Feb 2020

Using synthetic cell scaffolds to replace animal testing in cancer research

In the field of cancer research, the idea that scientists can disrupt cancer growth by changing the environment in which cancerous cells divide is growing in popularity. The primary way researchers have tested this theory is to conduct experiments using animals.

11 Feb 2020

Bats' fierce immune response to viruses could drive zoonotic emergence

It's no coincidence that some of the worst viral disease outbreaks in recent years -- SARS, MERS, Ebola, Marburg and likely the newly arrived 2019-nCoV virus -- originated in bats.

10 Feb 2020

Prenatal single cell blood test for gene defects

With the current state of knowledge regarding genetic testing, non-invasive prenatal testing (NIPT) is in favor for genetic testing in unborn babies, using fragments of DNA circulating in the mother’s blood.

4 Feb 2020

Death receptor pathway drives resistance to CAR T cell therapy

Some cancer cells refuse to die, even in the face of powerful cellular immunotherapies like CAR T cell therapy, and new research from the Abramson Cancer Center of the University of Pennsylvania is shedding light on why.

30 Jan 2020

Research reveals key molecular target for colorectal cancer therapy

Serine racemase is a multifunctional enzyme that carries out several different reactions in human cells, including the conversion of L-serine into pyruvate.

29 Jan 2020

New therapeutic strategy to fight against advanced melanoma

Scientists from the Centenary Institute have developed a new therapeutic strategy that could potentially help the fight against advanced-stage melanoma.

29 Jan 2020

Mycoplasma in Cell Culture: Fighting Back with Rapid Detection Kits

In this interview, discussing the effects of mycoplasma contamination on cell cultures and the development of rapid detection kits that provide answers in just thirty minutes.

From Gold Biotechnology, Inc. 24 Jan 2020

New discovery changes the understanding of gene expression

A group of University of Chicago scientists has uncovered a previously unknown way that our genes are made into reality.

22 Jan 2020

New technology repairs neuronal damage in an animal model of major motor nerve injury

Researchers at the University of Pittsburgh School of Medicine have created a biodegradable, implantable tube or “nerve guide” that can repair damage to major nerves in cases of traumatic injury.

22 Jan 2020

Horizon Discovery enters into licensing agreement with NGM for GS knockout CHO K1 cell line

Horizon Discovery Group plc, a global leader in the application of gene editing and gene modulation for cell line engineering, today announced that it will license its gene-edited Glutamine Synthetase knockout Chinese Hamster Ovary K1 cell line to NGM Biopharmaceuticals, Inc..

From Revvity 22 Jan 2020

Study uncovers anticancer potential of many non-oncology drugs

Drugs for diabetes, inflammation, alcoholism -- and even for treating arthritis in dogs -- can also kill cancer cells in the lab, according to a study by scientists at the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute.

20 Jan 2020

New uses for old medicines

It turns out that in the rush to invent new drugs to treat cancers, scientists may have overlooked some obvious possibilities of existing drugs currently being used for other diseases. A new study says that therapies for diabetes, inflammation and alcoholism, and even for dog arthritis, can also result in the successful killing of cancer cells in culture.

20 Jan 2020

Boston researchers develop novel approach to generate intestinal organoids in vitro

Boston researchers have developed a new way to generate groups of intestinal cells that can be used, among others, to make disease models in the lab to test treatments for diseases affecting the gastrointestinal system.

11 Jan 2020

New molecular probe senses the state of proteome in live cells

The folding state of the proteins in live cells often reflect the cell’s general health. Australian scientists have developed a molecular probe that senses the state of the proteome—the entire set of the proteins—by measuring the polarity of the protein environment.

10 Jan 2020

A HSC surface marker plays key role in ontogeny of hematopoiesis

A group of researchers at Osaka University revealed that ESAM (Endothelial cell-selective adhesion molecule), a surface marker for hematopoietic stem cells (HSCs) and vascular endothelial cells (ECs), played an important role in the ontogeny of hematopoiesis in mice, particularly in the development of adult-type erythropoiesis.

26 Dec 2019

Inserting end-modified DNA fragments with CRISPR-Cas9 yields highest efficiency

University of Illinois researchers achieved the highest reported rates of inserting genes into human cells with the CRISPR-Cas9 gene-editing system, a necessary step for harnessing CRISPR for clinical gene-therapy applications.

23 Dec 2019

Novel and targeted cellular product causes cell death in non-Hodgkin lymphoma models

Investigators at Rutgers Cancer Institute of New Jersey have found that a treatment based on a novel cellular product programmed to deliver an overabundance of chimeric antigen receptor causes cell death in non-Hodgkin lymphoma models that are sensitive or resistant to standard therapies.

16 Dec 2019

Researchers making major inroads into finding the cause of different diseases

Australian researchers are making major inroads into finding the cause of heart disease, Alzheimer's, cancer, diabetes and other diseases after discovering a further 148 proteins affected by oxidative stress in the human body.

12 Dec 2019

Combination regimen shows promising results in preclinical models of triple negative breast cancer

Tumor volume in a preclinical model of triple negative breast cancer (TNBC) was reduced four times more when an experimental polo-like kinase 1 (PLK1) inhibitor was combined with a standard-of-care chemotherapeutic agent than when the agent was used alone.

10 Dec 2019