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Researchers develop smart genetic reference library for locating disease-causing mutations

Researchers at Hiroshima University have developed a smart genetic reference library for locating and weeding out disease-causing mutations in populations.

3 Mar 2017

Nanoinjection leads to significantly higher survival rate of living cells

How do tumours grow? And how do bacteria transform harmless substances into medical agents? When biophysicists want to understand what is happening in living cells, they have to introduce fluorescent probes or other foreign molecules.

1 Mar 2017

Duke researchers discover potential cause for ALS syndromes using mouse models

A team of researchers at Duke University Medical Center led by Dr. Paulo Ferreira and whose work was supported by the National Institutes of Health has found that derailing the transport of certain receptors that carry cargoes from and to the nucleus of motor neurons causes motor neuron disease in mice.

1 Mar 2017

Using Spherical Nucleic Acids to Track and Treat Disease

Spherical nucleic acids are structures that are made by taking a nanoparticle template and using chemistry to arrange short strands of DNA or RNA on the surface of those particles. The spherical core of the nanoparticle creates a spherical arrangement of DNA or RNA, similar to tiny little balls of nucleic acids.

From Pittcon 1 Mar 2017

Study finding suggests new ways in which genetic mutations may cause brain disorders

Many kids say they love their mom and dad equally, but there are times when even the best prefers one parent over the other. The same can be said for how the body's cells treat our DNA instructions. It has long been thought that each copy - one inherited from mom and one from dad - is treated the same. A new study from scientists at the University of Utah School of Medicine shows that it is not uncommon for cells in the brain to preferentially activate one copy over the other.

25 Feb 2017

BIDMC review focuses on neural circuitry of wakefulness and sleep

Sleep remains an enduring biological mystery with major clinical relevance, according to a review by clinician-researcher Thomas Scammell, MD, of Beth Israel Deaconess Medical Center (BIDMC) and colleagues.

23 Feb 2017

Research on repair of broken hearts hints at possibility of new designer cardiovascular therapies

Unlike the self-repair abilities of our skin, bone and other tissues, which can readily heal and rebuild themselves after injury, evolution has left the mammalian heart with relatively little regenerative capacity.

22 Feb 2017

Scientists explore role of salt and immune system in raising blood pressure of females

Many of us have noted how our hands and feet swell after eating too much salt. Now scientists are exploring how high salt intake can also make cells throughout the body of females swell, rupture, dump their contents and die, triggering an immune reaction that contributes to chronic high blood pressure.

22 Feb 2017

Danish research may pave way for immunological treatment of cancer

Researchers from Aarhus University have found an important piece of the puzzle leading towards an understanding of how our innate immune system reacts against viral infections and recognises foreign DNA, for example from dying cancer cells.

21 Feb 2017

Researchers show how metabolism drives proliferation of tumor cells

The metabolic state of tumor cells contributes to signals that control the proliferation of tumor cells. Already the German biochemist and Nobel Prize laureate Otto H. Warburg observed in the 1920s that tumor cells radically change their metabolism.

20 Feb 2017

New imaging technology catches DNA naturally fluorescing

Many of the secrets of cancer and other diseases lie in the cell's nucleus. But getting way down to that level -- to see and investigate the important genetic material housed there -- requires creative thinking and extremely powerful imaging techniques.

17 Feb 2017

Brain scans reveal link between oxytocin and paternal caregiving in fathers

Fathers given boosts of the hormone oxytocin show increased activity in brain regions associated with reward and empathy when viewing photos of their toddlers, an Emory University study finds.

17 Feb 2017

ADHD linked to delayed development of five brain regions, study suggests

Attention-deficit hyperactivity disorder (ADHD) is associated with the delayed development of five brain regions and should be considered a brain disorder, according to a study published in The Lancet Psychiatry.

17 Feb 2017

UT Southwestern scientists unravel role of PARP enzymes in major cellular activities

A component of an enzyme family linked to DNA repair, stress responses, and cancer also plays a role in enhancing or inhibiting major cellular activities under physiological conditions, new research shows.

16 Feb 2017

Mice study shows how WAVE1 protein regulates the brain's response to cocaine

Cocaine is one of the most addictive substances known to man, and for good reason: By acting on levels of the "feel-good" chemical dopamine, it produces a tremendous sensation of euphoria.

15 Feb 2017

Researchers pinpoint new neural mechanism that regulates chronic stress response

In addition to the classic stress response in our bodies - an acute reaction that gradually abates when the threat passes - our bodies appear to have a separate mechanism that deals only with chronic stress.

15 Feb 2017

Emory researchers reveal 'matchmaker' role for protein linked to SMA

A puzzling question has lurked behind SMA, the leading genetic cause of death in infants. The disorder leads to reduced levels of the SMN protein, which is thought to be involved in processing RNA, something that occurs in every cell in the body.

14 Feb 2017

Review shows lipid nanoparticles as highly promising delivery systems in gene therapy

Lipid nanoparticles (SLNs and NLCs) are regarded as highly promising systems for delivering nucleic acids in gene therapy.

14 Feb 2017

CU Boulder scientists develop brain-based model to predict pain using variables beyond sensory input

Pain is a signal of actual or potential damage to the body, so it is natural to think of it as a localized sensation: knee pain in the knee, back pain in the back and so on.

14 Feb 2017

Non-invasive imaging technique accurately detects skin cancer without surgical biopsy

Researchers funded by the National Institute of Biomedical Imaging and Bioengineering have developed a non-invasive imaging technique that accurately detects skin cancer without surgical biopsy.

13 Feb 2017

Cell Nucleus News and Research

Researchers develop smart genetic reference library for locating disease-causing mutations

Nanoinjection leads to significantly higher survival rate of living cells

Duke researchers discover potential cause for ALS syndromes using mouse models

Using Spherical Nucleic Acids to Track and Treat Disease

Study finding suggests new ways in which genetic mutations may cause brain disorders

BIDMC review focuses on neural circuitry of wakefulness and sleep

Research on repair of broken hearts hints at possibility of new designer cardiovascular therapies

Scientists explore role of salt and immune system in raising blood pressure of females

Danish research may pave way for immunological treatment of cancer

Researchers show how metabolism drives proliferation of tumor cells

New imaging technology catches DNA naturally fluorescing

Brain scans reveal link between oxytocin and paternal caregiving in fathers

ADHD linked to delayed development of five brain regions, study suggests

UT Southwestern scientists unravel role of PARP enzymes in major cellular activities

Mice study shows how WAVE1 protein regulates the brain's response to cocaine

Researchers pinpoint new neural mechanism that regulates chronic stress response

Emory researchers reveal 'matchmaker' role for protein linked to SMA

Review shows lipid nanoparticles as highly promising delivery systems in gene therapy

CU Boulder scientists develop brain-based model to predict pain using variables beyond sensory input

Non-invasive imaging technique accurately detects skin cancer without surgical biopsy

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