Cell Nucleus News and Research

RSS

Penn researchers identify genome-wide changes caused by high-fat diet

By comparing two strains of mice -- one that becomes obese and diabetic on a high-fat diet and another resistant to a high-fat regimen -- researchers from the Perelman School of Medicine at the University of Pennsylvania identified genome-wide changes caused by a high-fat diet.

8 Mar 2017

Study reveals promising new strategy to attack deadly pediatric brain tumor

Researchers from Northwestern Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago have revealed new insight into how the most deadly pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG), may develop.

7 Mar 2017

Researchers test 'three-hit' theory of autism in mice

Since the first case was documented in the United States in 1938, the causes of autism have remained elusive. Hundreds of genes, as well as environmental exposures, have been implicated in these brain disorders.

7 Mar 2017

Researchers reveal how overloading of protein transport mechanisms triggers cellular defects

Researchers at Okayama University report in Scientific Reports how the overloading of protein transport mechanisms affects cell functioning. Over-expression of different types of target proteins leads to cellular growth defects, and the mechanism for transporting proteins out of a cell nucleus has the lowest over-expression tolerance.

7 Mar 2017

Scientists discover how misfolded proteins can damage cells’ energy-producing powerhouses

Working with yeast and human cells, researchers at Johns Hopkins say they have discovered an unexpected route for cells to eliminate protein clumps that may sometimes be the molecular equivalent of throwing too much or the wrong trash into the garbage disposal.

3 Mar 2017

Researchers develop smart genetic reference library for locating disease-causing mutations

Researchers at Hiroshima University have developed a smart genetic reference library for locating and weeding out disease-causing mutations in populations.

3 Mar 2017

Nanoinjection leads to significantly higher survival rate of living cells

How do tumours grow? And how do bacteria transform harmless substances into medical agents? When biophysicists want to understand what is happening in living cells, they have to introduce fluorescent probes or other foreign molecules.

1 Mar 2017

Duke researchers discover potential cause for ALS syndromes using mouse models

A team of researchers at Duke University Medical Center led by Dr. Paulo Ferreira and whose work was supported by the National Institutes of Health has found that derailing the transport of certain receptors that carry cargoes from and to the nucleus of motor neurons causes motor neuron disease in mice.

1 Mar 2017

Using Spherical Nucleic Acids to Track and Treat Disease

Spherical nucleic acids are structures that are made by taking a nanoparticle template and using chemistry to arrange short strands of DNA or RNA on the surface of those particles. The spherical core of the nanoparticle creates a spherical arrangement of DNA or RNA, similar to tiny little balls of nucleic acids.

From Pittcon 1 Mar 2017

Study finding suggests new ways in which genetic mutations may cause brain disorders

Many kids say they love their mom and dad equally, but there are times when even the best prefers one parent over the other. The same can be said for how the body's cells treat our DNA instructions. It has long been thought that each copy - one inherited from mom and one from dad - is treated the same. A new study from scientists at the University of Utah School of Medicine shows that it is not uncommon for cells in the brain to preferentially activate one copy over the other.

25 Feb 2017

BIDMC review focuses on neural circuitry of wakefulness and sleep

Sleep remains an enduring biological mystery with major clinical relevance, according to a review by clinician-researcher Thomas Scammell, MD, of Beth Israel Deaconess Medical Center (BIDMC) and colleagues.

23 Feb 2017

Research on repair of broken hearts hints at possibility of new designer cardiovascular therapies

Unlike the self-repair abilities of our skin, bone and other tissues, which can readily heal and rebuild themselves after injury, evolution has left the mammalian heart with relatively little regenerative capacity.

22 Feb 2017

Scientists explore role of salt and immune system in raising blood pressure of females

Many of us have noted how our hands and feet swell after eating too much salt. Now scientists are exploring how high salt intake can also make cells throughout the body of females swell, rupture, dump their contents and die, triggering an immune reaction that contributes to chronic high blood pressure.

22 Feb 2017

Danish research may pave way for immunological treatment of cancer

Researchers from Aarhus University have found an important piece of the puzzle leading towards an understanding of how our innate immune system reacts against viral infections and recognises foreign DNA, for example from dying cancer cells.

21 Feb 2017

Researchers show how metabolism drives proliferation of tumor cells

The metabolic state of tumor cells contributes to signals that control the proliferation of tumor cells. Already the German biochemist and Nobel Prize laureate Otto H. Warburg observed in the 1920s that tumor cells radically change their metabolism.

20 Feb 2017

New imaging technology catches DNA naturally fluorescing

Many of the secrets of cancer and other diseases lie in the cell's nucleus. But getting way down to that level -- to see and investigate the important genetic material housed there -- requires creative thinking and extremely powerful imaging techniques.

17 Feb 2017