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Elevated P2X7 receptor levels in COVID-19 patients correlate with disease severity

In a recent study posted to the bioRxiv preprint server, researchers demonstrated that the soluble P2X7 receptor is increased in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients. They also showed that the elevated P2X7 receptors correlated with coronavirus disease 2019 (COVID-19) severity.

9 Mar 2022

Whole-genome sequencing for determination of factors associated with critical COVID-19

In a recent study published in the journal Nature as an early release unedited manuscript, researchers conducted whole genomic sequencing (WGS) to ascertain factors contributing to critical coronavirus disease 2019 (COVID-19).

8 Mar 2022

A new view of SARS-CoV-2 genome structure

Researchers performed DMS mutational profiling with sequencing and DREEM clustering to determine the SARS-CoV-2 RNA secondary structure.

8 Mar 2022

Study explores immune escape mutations caused by prolonged viral shedding in immunocompromised COVID-19 patient

A new study examined a unique case of extended viral shedding in an immunocompromised patient that produced a series of SARS-CoV-2 immune escape mutations over a seven-month period.

8 Mar 2022

Current and future perspectives of mRNA technology

New research reports on the current and future perspectives on messenger ribonucleic acid technology, the platform on which the first successful COVID-19 vaccine was based.

8 Mar 2022

Effect of COVID-19 mRNA vaccine on in vitro glial cells of the brain studied by Raman spectroscopy and imaging

Researchers studied how the mRNA-based BNT162b2 COVID-19 vaccine altered the biochemical composition of glial and glioma brain cells in vitro.

8 Mar 2022

SARS-CoV-2 variant identification by RT-qPCR assays targeting mutations

In a recent study posted to the medRxiv* preprint server, researchers investigated the efficacy of diagnostic tests for identifying severe acute respiratory syndrome coronavirus (SARS-CoV-2) variants of concern (VOCs).

8 Mar 2022

Study reveals the potential of novel antiviral drug combinations to stop COVID-19 spread

Researchers from Columbia Engineering, Fiocruz's Center for Technological Development in Health and the Oswaldo Cruz Institute in Brazil, Memorial Sloan Kettering Cancer Center, and Rockefeller University recently reported that, by combining inhibitors of polymerases and exonucleases--enzymes that allow SARS-CoV-2 to reproduce--they were able to reduce SARS-CoV-2 replication 10 times more than when using just the polymerase inhibitors.

7 Mar 2022

Delta and Omicron coinfections identified in France

A new study shows both the Omicron and Delta variants were able to infect patients with healthy immune function.

7 Mar 2022

Patterns of bat β-coronaviruses evolution

Researchers conduct an evolutionary analysis of SARS-CoV-2-related bat β-coronavirus genomes.

4 Mar 2022

Similarities between SARS-CoV-2 and human retroelements explored

A new study investigated the similarities between SARS-CoV-2 and human retroelements.

2 Mar 2022

Novel coronavirus identified in Swedish bank voles

Researchers recently discovered a new coronavirus, named Grimso virus, in Swedish bank voles, using samples collected between 2015 and 2017.

1 Mar 2022

A study on the evolution of avian coronavirus escape mutants in vitro

A recent study included an in vitro assessment of the effect of antibody titers and vaccine combinations on the emergence of escape mutants of AvCoV.

28 Feb 2022

The need for a holistic and unbiased approach to develop a more universal vaccine for coronaviruses

Researchers emphasized the need to take on a holistic and unbiased approach to develop a universal vaccine for coronaviruses, including SARS-CoV-2, which is a biomedical priority during the ongoing COVID-19 pandemic.

28 Feb 2022

SARS-CoV-2 viroporins mediate cytokine storm via mitochondrial permeability transition pore

Researchers demonstrated that the SARS-CoV-2 viroporins precipitate cytokine storm via the alteration of mitochondrial physiology in severe COVID-19.

24 Feb 2022

Omicron BA. 2 reinfections can occur shortly following BA.1 infection

Researchers investigated the probability of Omicron BA.2 reinfections following SARS-CoV-2 Omicron BA.1 initial infection by whole genomic sequencing in the period of dominance of these subvariants in Denmark.

24 Feb 2022

First reported case of a cat infected with SARS-CoV-2 Delta AY.3 variant

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is hurting our loved ones — even those that walk on four legs. Researchers from the University of Pennsylvania documented the recovery of an 11-year old indoor housecat living in Delaware who first presented to the veterinary hospital after experiencing distressing gastrointestinal symptoms.

23 Feb 2022

Nucleotide News and Research

Elevated P2X7 receptor levels in COVID-19 patients correlate with disease severity

Whole-genome sequencing for determination of factors associated with critical COVID-19

A new view of SARS-CoV-2 genome structure

Study explores immune escape mutations caused by prolonged viral shedding in immunocompromised COVID-19 patient

Current and future perspectives of mRNA technology

Effect of COVID-19 mRNA vaccine on in vitro glial cells of the brain studied by Raman spectroscopy and imaging

SARS-CoV-2 variant identification by RT-qPCR assays targeting mutations

Study reveals the potential of novel antiviral drug combinations to stop COVID-19 spread

Delta and Omicron coinfections identified in France

Patterns of bat β-coronaviruses evolution

Similarities between SARS-CoV-2 and human retroelements explored

Novel coronavirus identified in Swedish bank voles

A study on the evolution of avian coronavirus escape mutants in vitro

The need for a holistic and unbiased approach to develop a more universal vaccine for coronaviruses

SARS-CoV-2 viroporins mediate cytokine storm via mitochondrial permeability transition pore

Omicron BA. 2 reinfections can occur shortly following BA.1 infection

First reported case of a cat infected with SARS-CoV-2 Delta AY.3 variant

Specialized subset of CD4+ T cells jump into action early during an infection, study shows

Novel platform can become a potential approach for personalized cancer treatments

Severity of SARS-CoV-2 infections with Omicron BA.2 variant relative to the BA.1 variant in South Africa

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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