Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Scientists take a close look at early events in immune response

A Sandia National Laboratories research team led by Anup Singh is taking a new approach to studying how immune cells respond to pathogens in the first few minutes and hours of exposure.

4 Apr 2007

Recognition for cancer researchers

World-class cancer researchers whose science has significantly contributed to progress in the fight against cancer will be recognized April 14-18, 2007, by the American Association for Cancer Research (AACR) at its 2007 Annual Meeting in Los Angeles, Calif.

3 Apr 2007

Effect of Torcetrapib on the progression of coronary atherosclerosis

Investigators report that torcetrapib, a drug that substantially raises high-density lipoprotein cholesterol or HDL (the "good" cholesterol), did not slow the progression of plaque buildup in the coronary arteries as measured using an ultrasound probe (IVUS).

2 Apr 2007

Optical biopsy finds cancers in first tests on human tissue

In its first laboratory tests on human tissue, a light-based probe built by researchers at Duke University's Pratt School of Engineering almost instantly detected the earliest signs of cancer in cells that line internal organs.

2 Apr 2007

Higher trans fat levels in blood associated with elevated risk of heart disease

High consumption of trans fat, found mainly in partially hydrogenated vegetable oils and widely used by the food industry, has been linked to an increased risk of coronary heart disease (CHD).

30 Mar 2007

Study provides strongest link to date between trans fat and heart disease

High consumption of trans fat, found mainly in partially hydrogenated vegetable oils and widely used by the food industry, has been linked to an increased risk of coronary heart disease (CHD).

28 Mar 2007

Obesity at the time of prostate-cancer diagnosis dramatically increases the risk of dying from the disease

Obese men who are diagnosed with prostate cancer have more than two-and-a-half times the risk of dying from the disease as compared to men of normal weight at the time of diagnosis, according to a study by researchers at Fred Hutchinson Cancer Research Center.

15 Mar 2007

Large-scale Japanese study finds soy protective against localized prostate cancer, but not advanced

The largest study examining the relationship between the traditional soy-rich Japanese diet and development of prostate cancer in Japanese men has come to a seemingly contradictory conclusion: intake of isoflavone chemicals, derived largely from soy foods, decreased the risk of localized prostate cancer but increased the risk of advanced prostate cancer.

15 Mar 2007

Researchers uncover genetic sequence responsible for rare form of pancreatic cancer

Pancreatic ductal adenocarcinoma is an almost uniformly fatal disease regardless of the stage at time of diagnosis. However, a small percentage of patients develop a form of ductal adenocarcinoma associated with cystic lesions that can be detected earlier, is less aggressive and has a 50 percent long-term survival rate.

14 Mar 2007

Biomarker for lung cancer identified

Researchers from Boston University School of Medicine (BUSM) have identified a gene expression marker that distinguishes smokers with lung cancer from smokers without the disease. The findings, reported in the March 1, 2007 advanced on-line edition of Nature Medicine, may have immediate clinical relevance and public health impact.

5 Mar 2007

Aspirin offers help for Barrett's esophagus

Researchers at Fred Hutchinson Cancer Research Center have found that people with the most-aggressive form of Barrett's esophagus, a precancerous condition that can lead to esophageal cancer, may benefit the most from preventive therapy with aspirin, ibuprofen and other nonsteroidal anti-inflammatory drugs, or NSAIDs.

27 Feb 2007

Plant-based omega-3 polyunsaturated fatty acids may have a protective effect on bone health

Normally, most of the omega-3 fatty acids in the diet are plant-derived and come mainly from soybean and canola oil. Other sources are flaxseed, flaxseed oil, walnuts and walnut oil.

19 Feb 2007

Breath test to detect lung cancer

A new breath test has been reported to detect lung cancer in its early stage. Lung cancer is the leading cause of cancer death in the United States, and doctors believe that early detection could offer sufferers their best chance for early survival.

18 Feb 2007

Survey finds perceived risk of recurrence is low in African American breast cancer survivors

A unique survey of African American breast cancer survivors at heightened risk for hereditary breast cancer has found the majority do not believe they have an increased chance of developing the cancer again.

15 Feb 2007

Active lifestyle reduces risk of invasive breast cancer

Six or more hours per week of strenuous recreational activity may reduce the risks of invasive breast cancer by 23 percent, according to researchers from the University of Wisconsin Paul P. Carbone Comprehensive Cancer Center (UWCCC).

15 Feb 2007

Twin study on the increased cardiometabolic risk in obesity

A unique monozygotic twin study by researchers from the Finnish Twin Cohort, Helsinki University Central Hospital, and VTT Technical Research Centre of Finland found that obesity, already in its early stages and independent of genetic influences, is associated with deleterious alterations in the lipid metabolism known to facilitate atherogenesis, inflammation and insulin resistance.

15 Feb 2007

Indicators for risk of heart disease are higher in passive smokers

Exposure to second-hand smoke at work, home or elsewhere results in a disproportionate rise in markers that increase the risk of cardiovascular disease, University of Nottingham researchers have found.

12 Feb 2007

International consortium to get to heart of coronary artery disease

An international consortium has been launched to tackle coronary artery disease using the latest scientific tools. Funded by the European Commission, the initiative will build on recent advances in genomic science and the understanding of our genes to develop effective strategies for preventing and treating the disease.

7 Feb 2007

Severe form of "enlarged prostate" discovered

Millions of middle-aged and older men experience the symptoms of an enlarged prostate multiple times during the day and night. What they may not know is that the disease known as BPH (benign prostatic hyperplasia), marked by urgency and frequent urination, is not one but at least a pair of disorders, and that one of the pair - tied to a newly identified gene - has far more serious implications.

5 Feb 2007

Bright quantum dots help basic cancer biology studies

Though there is little doubt that nanoscale devices are going to play a critical role in improving cancer detection and treatment over the next five to ten years, nanoparticles are already having a major impact on the way that cancer biologists study the processes that go awry within malignant and metastatic cells.

5 Feb 2007