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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

NLRP3 inflammasome plays a role in podocyte aging

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, entitled, "Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span."

8 Aug 2023

Nationwide Children's Hospital pioneers new gene therapy for Duchenne muscular dystrophy

In a landmark moment for the Abigail Wexner Research Institute at Nationwide Children's, a 5-year-old from Bellefontaine, Ohio, received the first dose of a recently approved gene therapy for Duchenne muscular dystrophy at Nationwide Children's Hospital, where the therapy was invented and initially tested.

8 Aug 2023

RAGE plays key role in cellular mechanisms of plasticity in aggressive triple-negative breast cancer

Published online ahead of print in the journal Oncogene , a study led by Josep Villanueva, an Investigator at the Vall d'Hebron Institute of Oncology (VHIO), shows that the receptor for advanced glycation end-product (RAGE) plays a key role in cellular mechanisms of plasticity in mesenchymal triple-negative breast cancer (TNBC) that transform epithelial cells into mesenchymal cells as potent drivers of cancer cell proliferation and tumor invasion.

8 Aug 2023

Mitochondrial protein structure activates cell's integrated stress response

Often referred to as the "powerhouses of the cell," mitochondria are well known for their role as energy suppliers, but these organelles are also critical for maintaining our overall health.

8 Aug 2023

Outcome markers in COPD patients with COVID-19

Researchers identify potential markers for severe COVID-19 and death in COPD patients.

8 Aug 2023

Are teicoplanin-non-susceptible Staphylococcus epidermidis strains increasing?

Researchers elucidated the incidence patterns of teicoplanin-non-susceptible Staphylococcus epidermidis (Teico-NS S. epidermidis) over six years.

8 Aug 2023

Identification of plasma proteins associated with ovarian cancer risk

Researchers performed proteomic Mendelian randomization as well as co-localization analyses to identify drug targets for ovarian cancer.

8 Aug 2023

Study finds that nose-picking may increase COVID-19 risk in health care workers

Researchers investigated whether physical and behavioral features among healthcare workers, e.g. nose picking, could increase the risk of SARS-CoV-2 infection.

8 Aug 2023

Is a Western diet a risk factor for major depressive disorder?

Researchers investigated whether the Western diet (WD) was a risk element for major depressive disorder (MDD) patients.

8 Aug 2023

Molecular insights: Detecting gene fusions offers new avenues for advanced cancer management

Study identifies gene fusions to understand their relationship with observed pathologies in cancer patients.

8 Aug 2023

The green tea effect: From gut microbes to weight loss, new insights emerge

The impact of green tea and its functional components on body weight and gut microbiota regulation.

8 Aug 2023

Could pizza consumption improve rheumatoid arthritis severity?

Investigating whether pizza and its ingredients modulated RA disease activity.

8 Aug 2023

High troponin levels associated with increased risk of death from any cause

A high level of troponin - a protein normally used to exclude the possibility of a heart attack in patients with chest pain - may signal a heightened risk of death from any cause within the next couple of years, even in the absence of known or suspected cardiovascular disease, suggests research published online in the journal Heart.

7 Aug 2023

Researchers develop new method to find mutations in pediatric brain tumors

Researchers at Uppsala university have developed a new method to find mutations in brain tumors in children.

7 Aug 2023

NCI funds study to investigate the underlying cellular mechanisms that drive ER+ breast cancer

The National Cancer Institute (NCI) has awarded a 5-year, $2.7 million grant to researchers at Sanford Burnham Prebys to investigate and elucidate the underlying cellular mechanisms that drive the most common form of breast cancer.

7 Aug 2023

Researchers uncover genetic machinery responsible for EBV-induced B cell growth transformation

B cells or B lymphocytes are an important part of the body's immune system. When healthy B cells are infected with the Epstein-Barr virus (EBV), they undergo growth transformation, a process that immortalizes B cells, leading to their uncontrolled proliferation.

7 Aug 2023