Immune System News and Research

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NAU scientist collaborating on vault-based vaccine to prevent and treat COVID-19

C. Todd French, assistant professor of biology and leader of Northern Arizona University's new COVID-19 Testing Service Center, is working with scientists at Vault Pharma, an emerging biotechnology company, to test candidate vaccines against the novel coronavirus.

1 Jun 2020

Study uncovers how cancer cells protect themselves from viruses

Researchers at the Francis Crick Institute have uncovered how cancer cells protect themselves from viruses that are harmful to tumors but not to healthy cells. These findings could lead to improved viral treatments for the disease.

1 Jun 2020

Study highlights potential benefits of new drug for inflammatory diseases

New research conducted by the University of Liverpool and AKL Research and Development Ltd, published in Inflammopharmacology, highlights the potential benefits of a new drug treatment on the human body's immune response in inflammation.

1 Jun 2020

Ruxolitinib shows promise in severe COVID-19

An anti-inflammatory drug Ruxolitinib has shown promising results in the treatment of severe coronavirus disease COVID-19. The study titled, “Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial,” was published as a pre-proof for the Journal of Allergy and Clinical Immunology.

31 May 2020

New immunotherapy for metastatic non-small cell lung cancer shows promise in clinical trial

A new type of immunotherapy treatment for metastatic non-small cell lung cancer (NSCLC) is being tested by Missak Haigentz, Jr., MD, medical director of hematology and oncology for Atlantic Health System.

30 May 2020

Immunotherapy doubles progression-free survival time of patients with advanced bowel cancer

A large international trial involving UCL and University College London Hospitals NHS Foundation Trust (UCLH) has found that pembrolizumab, a form of immunotherapy, more than doubled the 'progression free survival' time of patients with a specific subtype of advanced bowel cancer, when compared with chemotherapy.

30 May 2020

Scientists identify factors influencing outcomes in kidney cancer patients treated with immunotherapy

By analyzing tumors from patients treated with immunotherapy for advanced kidney cancer in three clinical trials, Dana-Farber Cancer Institute scientists have identified several features of the tumors that influence their response to immune checkpoint inhibitor drugs.

30 May 2020

Newer treatment approaches may reduce risk of therapy-related hematologic cancers

While breakthrough treatments have emerged for several cancers over the last two decades, driving striking improvements in survival and other clinical outcomes, too little is known about the risk of therapy-related hematologic cancers following targeted and immunotherapeutic approaches.

29 May 2020

Using gene therapy to help the body to make its own cancer drugs

Imagine that we could instruct our bodies to make the drugs they need themselves. The gene technology that makes this possible is called mRNA therapy, which may become a major tool in the treatment of multiple diseases.

29 May 2020

New tool may predict best treatment for multiple myeloma

In 1844, multiple myeloma was first treated with a rhubarb pill and an infusion of orange peel. Since then, more than 15 drugs have earned FDA approval to treat multiple myeloma and with so many options, a major question has become what cocktail and sequence is best?

29 May 2020

Radiation and surgery do not prolong survival in newly diagnosed metastatic breast cancer

Up to now, women who present with a new diagnosis of breast cancer that is already in an advanced stage (stage IV) face an unanswered question about whether surgery and radiation to the tumor in the breast (local therapy) will prolong survival compared to the traditional treatment of systemic treatment alone.

29 May 2020

Rare deadly disease linked to coronavirus infection seen in children

Now, new evidence has shown that children with coronavirus disease (COVID-19) experience a Kawasaki-like illness, called multisystem inflammatory syndrome in children (MIS-C). The complication is akin to toxic shock syndrome, a condition that occurs due to sepsis. Though rare, the condition is life-threatening.

29 May 2020

Ferritin heavy chain protein shows promise as a potential SARS-CoV-2 vaccine or antiviral

A new study published on the online preprint server bioRxiv in May 2020 reports the construction and testing of a new ferritin-based antigen-bearing protein that has biological activity towards the ACE2 receptor. This could indicate its potential for development as a vaccine or antiviral.

28 May 2020

Characterizing immune cells in malignant brain tumors

It is not always possible to completely remove malignant brain tumors by surgery so that further treatment is necessary.

28 May 2020

New drug combinations could help overcome genetic immunotherapy resistance

A new study from researchers at the UCLA Jonsson Comprehensive Cancer Center helps explain how disruptions in genes can lead to the resistance to one of the leading immunotherapies, PD-1 blockade, and how new drug combinations could help overcome resistance to the anti-PD-1 therapy in a mechanistically-based way.

28 May 2020

Transgenic mouse model of HLH may play key role in saving lives during COVID-19

A transgenic mouse developed at Cincinnati Children's to model the deadly childhood immune disease HLH (hemophagocytic lymphohistiocytosis) may play a key role in saving lives during the COVID-19 virus pandemic.

28 May 2020

PKU-led team identifies potent neutralizing antibodies against SARS-CoV-2

A joint research team led by Sunney Xie, Director of Beijing Advanced Innovation Center for Genomics at Peking University has successfully identified multiple highly potent neutralizing antibodies against the novel coronavirus SARS-CoV-2, the causative virus of the respiratory disease COVID-19, from convalescent plasma by high-throughput single-cell sequencing.

28 May 2020

Molecular signatures can predict outcome of sepsis patients based on their immune response

Scientists have identified molecular signatures in the immune component of the blood which indicate how patients in intensive care with sepsis, septic shock and systemic inflammatory response syndrome are likely to respond to the conditions.

28 May 2020

SignalChem Biotech Inc. launches COVID-19 elisa kits for diagnostic research

SignalChem, a global leader in cell signaling and protein engineering, has been conducting research on new coronaviruses since the outbreak of the virus.

From SignalChem Biotech Inc. 28 May 2020

Study shows children and adults have a comparable expression of SARS-CoV-2 entry-related genes

A recent paper by researchers from China demonstrated comparable expression levels of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry mediators in adults and children, suggesting that previously implied difference in viral-entry associated genes is likely not responsible for milder symptoms in children. The study is currently available on the medRxiv preprint server.

27 May 2020

Immune System News and Research

NAU scientist collaborating on vault-based vaccine to prevent and treat COVID-19

Study uncovers how cancer cells protect themselves from viruses

Study highlights potential benefits of new drug for inflammatory diseases

Ruxolitinib shows promise in severe COVID-19

New immunotherapy for metastatic non-small cell lung cancer shows promise in clinical trial

Immunotherapy doubles progression-free survival time of patients with advanced bowel cancer

Scientists identify factors influencing outcomes in kidney cancer patients treated with immunotherapy

Newer treatment approaches may reduce risk of therapy-related hematologic cancers

Using gene therapy to help the body to make its own cancer drugs

New tool may predict best treatment for multiple myeloma

Radiation and surgery do not prolong survival in newly diagnosed metastatic breast cancer

Rare deadly disease linked to coronavirus infection seen in children

Ferritin heavy chain protein shows promise as a potential SARS-CoV-2 vaccine or antiviral

Characterizing immune cells in malignant brain tumors

New drug combinations could help overcome genetic immunotherapy resistance

Transgenic mouse model of HLH may play key role in saving lives during COVID-19

PKU-led team identifies potent neutralizing antibodies against SARS-CoV-2

Molecular signatures can predict outcome of sepsis patients based on their immune response

SignalChem Biotech Inc. launches COVID-19 elisa kits for diagnostic research

Study shows children and adults have a comparable expression of SARS-CoV-2 entry-related genes

Understanding the DNA Damage Response in Innate Immunity eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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