Clinical Trial News and Research

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Cutting-edge precision medicine spreading from specialist cancer units to community setting

Nearly 1 in 4 patients with advanced cancer, treated at Comprehensive Cancer Care Network centers in the US, are receiving innovative drugs matched to DNA mutations in their tumors.

8 Oct 2018

Neoadjuvant clinical trial of immune checkpoint blockade for melanoma patients yields high response rate

Combination checkpoint blockade before surgery (neoadjuvant therapy) produced a high response rate among patients with high-risk stage 3 melanoma, with nearly half having no sign of disease at surgery, but a high incidence of side effects caused the trial to be closed early.

8 Oct 2018

Intact Vascular to present TOBA II pivotal clinical trial data at VIVA Conference

Intact Vascular, Inc., a developer of medical devices for minimally invasive peripheral vascular procedures, today announced that data from its Tack Optimized Balloon Angioplasty II pivotal clinical trial will be presented at the 15th Annual VIVA Conference in Las Vegas, NV on November 5-8.

8 Oct 2018

FDA and EMA accept Novartis' regulatory application for siponimod to treat SPMS in adults

Novartis today announced that both the US Food and Drug Administration and European Medicines Agency have accepted the company's New Drug Application and Marketing Authorization Application respectively, for investigational oral, once-daily siponimod (BAF312) for the treatment of secondary progressive multiple sclerosis in adults.

8 Oct 2018

Postmenopausal women who lost weight had lower risk of developing invasive breast cancer

In a study of postmenopausal women, participants who lost weight had a lower risk of developing invasive breast cancer than those who maintained or gained weight. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings suggest that weight loss may help lower postmenopausal women's breast cancer risk.

8 Oct 2018

Diet and weight may influence response to bipolar disorder treatment, shows study

Data from a clinical trial has shown that how people respond to treatment for Bipolar Disorder may be influenced by their weight and the overall quality of their diet, including whether they are eating a diet high in foods thought to contribute to general inflammation.

8 Oct 2018

T-CALM Phase 2 clinical study results offer hope for essential tremor patients

Cavion, Inc., a leading clinical stage biotechnology company committed to developing novel therapeutics for people with neurological diseases, today announced promising results of the T-CALM Phase 2 clinical trial of its first-in-class T-type calcium channel modulator CX-8998 in essential tremor.

7 Oct 2018

Dementia prevention trial participants are motivated by altruism, study suggests

Researchers at University of California San Diego School of Medicine, with collaborators across the country, report that people who participate in dementia prevention trials are primarily motivated by altruism and pleased to help.

6 Oct 2018

FDA approves expanded use of Gardasil 9 for adults aged 27 to 45 years

The U.S. Food and Drug Administration today approved a supplemental application for Gardasil 9 (Human Papillomavirus (HPV) 9-valent Vaccine, Recombinant) expanding the approved use of the vaccine to include women and men aged 27 through 45 years.

6 Oct 2018

Researchers receive $1.2 million grant to test potential treatment for metastatic breast cancer

A team of Medical University of South Carolina Hollings Cancer Center researchers received a three-year, $1.2 million grant from the U.S. Department of Defens to test a potential therapeutic antibody that could block breast cancer growth with fewer side effects, opening up potential for future drug development.

5 Oct 2018

Researchers receive DoD grant to test efficacy of stem cell therapy for eye injuries

Researchers at the University of Illinois at Chicago have received a four-year, $5.25 million grant from the U.S. Department of Defense to lead a multi-site clinical trial to test the efficacy of a stem cell-based treatment for eye injuries.

5 Oct 2018

Pilot study shows how migraine can be treated without medicine

By slightly changing the body's own molecules using a small inhaler, certain migraine patients can either cut down on medication or do without it completely. This is shown by a pilot study which has been published in the scientific journal Cephalalgia.

4 Oct 2018

Weight loss drug reduces risk of diabetes in patients with pre-diabetes, finds study

At the 2018 Meeting of the European Association for the Study of Diabetes, Brigham and Women's Hospital investigators from the Thrombolysis in Myocardial Infarction Study Group presented diabetes-related findings from CAMELLIA-TIMI 61, a clinical trial of overweight and obese patients designed to test lorcaserin, a weight loss drug manufactured by the trial's sponsor, Eisai Inc.

4 Oct 2018

Doctors use bacteriophages to treat patient with multi-drug resistant bacterial infection

The married professors were spending their Thanksgiving holiday in Egypt when the husband, Thomas L. Patterson, Ph.D., got very sick very quickly, experiencing fever, nausea and a racing heartbeat. By the time Patterson was accurately diagnosed with a highly multi-drug resistant bacterial infection, he was near death.

4 Oct 2018

New ReFRAME drug repurposing collection offers hope for treating major diseases

Each year, millions of people worldwide suffer from potentially fatal infectious diseases that often leave survivors facing a lifetime of related health problems. But what if drugs against such diseases already existed but nobody knew it?

4 Oct 2018

RCIGM and IDbyDNA launch clinical trial to improve diagnostics for pediatric CNS infections

The Rady Children's Institute for Genomic Medicine and IDbyDNA, a metagenomics technology company translating microbial genomics into actionable information for healthcare providers, have launched a clinical trial to improve diagnostics for pediatric central nervous system infections.

3 Oct 2018

Genentech announces clinical data from studies investigating risdiplam in spinal muscular atrophy

Genentech, a member of the Roche Group, announced today interim clinical data from the dose-finding parts of the pivotal FIREFISH and SUNFISH studies investigating risdiplam in spinal muscular atrophy.

3 Oct 2018

Alnylam submits CTA application to MHRA to initiate Phase 1/2 study of ALN-AAT02

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today that it has submitted a Clinical Trial Authorization application to the Medicines and Healthcare products Regulatory Agency to initiate a Phase 1/2 study of ALN-AAT02, an investigational RNAi therapeutic targeting alpha-1 antitrypsin for the treatment of AAT deficiency-associated liver disease.

3 Oct 2018

Human clinical trial of investigational calcification inhibitor generates promising results

Cardiovascular calcification is a major health concern in patients with kidney failure undergoing hemodialysis.

3 Oct 2018

CBT for insomnia may slow or reverse cortical atrophy in patients with co-morbid fibromyalgia

Preliminary findings from a pilot study suggest that cognitive behavioral therapy for insomnia may slow or even reverse the atrophy of cortical gray matter in patients who have co-morbid fibromyalgia.

3 Oct 2018

Clinical Trial News and Research

Cutting-edge precision medicine spreading from specialist cancer units to community setting

Neoadjuvant clinical trial of immune checkpoint blockade for melanoma patients yields high response rate

Intact Vascular to present TOBA II pivotal clinical trial data at VIVA Conference

FDA and EMA accept Novartis' regulatory application for siponimod to treat SPMS in adults

Postmenopausal women who lost weight had lower risk of developing invasive breast cancer

Diet and weight may influence response to bipolar disorder treatment, shows study

T-CALM Phase 2 clinical study results offer hope for essential tremor patients

Dementia prevention trial participants are motivated by altruism, study suggests

FDA approves expanded use of Gardasil 9 for adults aged 27 to 45 years

Researchers receive $1.2 million grant to test potential treatment for metastatic breast cancer

Researchers receive DoD grant to test efficacy of stem cell therapy for eye injuries

Pilot study shows how migraine can be treated without medicine

Weight loss drug reduces risk of diabetes in patients with pre-diabetes, finds study

Doctors use bacteriophages to treat patient with multi-drug resistant bacterial infection

New ReFRAME drug repurposing collection offers hope for treating major diseases

RCIGM and IDbyDNA launch clinical trial to improve diagnostics for pediatric CNS infections

Genentech announces clinical data from studies investigating risdiplam in spinal muscular atrophy

Alnylam submits CTA application to MHRA to initiate Phase 1/2 study of ALN-AAT02

Human clinical trial of investigational calcification inhibitor generates promising results

CBT for insomnia may slow or reverse cortical atrophy in patients with co-morbid fibromyalgia

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