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Megaphages detected in the intestinal tract of humans who eat high-fiber, low-fat diet

Viruses plague bacteria just as viruses like influenza plague humans. Some of the largest of these so-called bacteriophages have now been found in the human gut, where they periodically devastate bacteria just as seasonal outbreaks of flu lay humans low, according to a new study led by University of California, Berkeley, scientists.

29 Jan 2019

Two major forms of CD44 have distinct biological functions in breast cancer, shows study

One of the main obstacles to successfully treating breast cancer is the cells' ability to change in ways that make them resistant to treatment.

29 Jan 2019

Big data opens door for characterizing immunity-related genome in Japanese population

Although different genes are distributed widely across chromosomes, many genes related to the immune system are clustered together on human chromosome 6, in a segment called the major histocompatibility complex (MHC) region.

29 Jan 2019

Fibrosis-targeting drugs may benefit patients with late-stage, metastatic breast cancer

A Massachusetts General Hospital (MGH) research team has found that the overgrowth of connective called fibrosis may block the effectiveness of immunotherapies against metastatic breast cancer.

29 Jan 2019

Researchers identify why heart attack triggers arrhythmia in some people

A team of researchers led by the University of California San Diego has identified a genetic pathway that causes some individuals to develop an abnormal heart rhythm, or arrhythmia, after experiencing a heart attack. They have also identified a drug candidate that can block this pathway.

29 Jan 2019

RNA-induced gene fusion can occur in mammalian cells, reveals study

A fusion gene is a new gene made by joining parts of two different genes. The current thought is that fusion genes can happen in cells with unstable genome when part of the DNA from one chromosome moves to another chromosome.

29 Jan 2019

Research provides new understanding of genome regulation in early life

After the fertilization of an egg cell, two become one; two sets of genetic information combine to form a genome. We can think of the egg and sperm as information capsules with stored instructions for starting a new life, but post fertilization, what kick starts the interpretation of these instructions?

29 Jan 2019

EZH2 mutations can be used as marker for diagnosing different types of cancers

Inside the cell, DNA is tightly wrapped around proteins and packed in a complex, 3D structure that we call "chromatin".

29 Jan 2019

Genetic testing to be provided by the NHS in exchange for genomic data

The NHS is going to start providing genetic tests in exchange for patients in England who agree to share their genomic data so that it can be used for research.

28 Jan 2019

Researchers discover immune regulator that appears to dictate glioblastoma

Researchers at The University of Texas MD Anderson Cancer Center have discovered an immune regulator that appears to dictate glioblastoma progression by shutting down immune surveillance, indicating a potential new area of therapeutic investigation.

28 Jan 2019

Scientists pinpoint mechanism that leads to steroid diabetes

Patients undergoing long-term treatment with steroids may suffer from metabolic side effects. Researchers at the Helmholtz Zentrum München and the Ludwig Maximilians University of Munich, partners in the German Center for Diabetes Research, have now pinpointed a mechanism that leads to so-called steroid diabetes

25 Jan 2019

Copy number variants linked with 'schizophrenia-like' subtype of bipolar disorder

A form of rare genomic structural variation called copy number variants (CNVs) may be more closely associated with schizophrenia than bipolar disorder.

25 Jan 2019

Discovery could guide future treatments for patients with hypertension

A team of Vanderbilt University Medical Center researchers, working with the U.S. Department of Veteran's Affairs, has discovered genetic associations with blood pressure that could guide future treatments for patients with hypertension.

25 Jan 2019

Genetic risk for developing psychiatric disorders or cognitive traits manifest in brain structure from childhood

There is only scant scientific evidence available on whether the genetic risk for developing specific psychiatric disorders or cognitive traits is manifest in brain structure from childhood and, to date, studies have focused primarily on adult populations. The question remains unanswered.

25 Jan 2019

Ebola virus identified in a West African bat

The government of Liberia, in partnership with the Center for Infection and Immunity (CII) at the Columbia University Mailman School of Public Health and EcoHealth Alliance, announced the discovery of Ebola virus in a bat in Liberia.

24 Jan 2019

Researchers uncover new role of heterochromatin in maintaining chromosomal integrity

Although many people are aware that chromosomal damage and shortening contribute to the aging process, understanding how chromosomal defects occur is about more than just finding a way to turn back the clock. Large changes in the structure of chromosomes, known as gross chromosomal rearrangements, can result in cell death or genetic diseases such as cancer.

24 Jan 2019

African scientists to build research capacity in African countries, develop ongoing scientific partnerships

Ten African scientists have been selected for training at the National Institutes of Health as part of a new fellowship program to build research capacity in African countries and develop ongoing scientific partnerships.

24 Jan 2019

Old oligodendrocytes can repair damage in the brains of patients with multiple sclerosis

A new study shows that there is a very limited regeneration of cells in the brain of patients diagnosed with multiple sclerosis.

23 Jan 2019

Ludwig researchers find ways to make resistant melanomas susceptible to immunotherapy

A Ludwig Cancer Research study has uncovered a cellular mechanism by which melanomas that fail to respond to checkpoint blockade may be made susceptible to such immunotherapies.

23 Jan 2019

Unique data combination helps FinnGen researchers to fund links between genetic factors and health

The FinnGen study, launched in autumn 2017, is a broad academic-industrial collaboration between the Finnish biobanks and their respective Universities, University Hospitals, the Institute of Health and Welfare, the Finnish Red Cross Blood Service and now nine international pharmaceutical companies

23 Jan 2019

Genome News and Research

Megaphages detected in the intestinal tract of humans who eat high-fiber, low-fat diet

Two major forms of CD44 have distinct biological functions in breast cancer, shows study

Big data opens door for characterizing immunity-related genome in Japanese population

Fibrosis-targeting drugs may benefit patients with late-stage, metastatic breast cancer

Researchers identify why heart attack triggers arrhythmia in some people

RNA-induced gene fusion can occur in mammalian cells, reveals study

Research provides new understanding of genome regulation in early life

EZH2 mutations can be used as marker for diagnosing different types of cancers

Genetic testing to be provided by the NHS in exchange for genomic data

Researchers discover immune regulator that appears to dictate glioblastoma

Scientists pinpoint mechanism that leads to steroid diabetes

Copy number variants linked with 'schizophrenia-like' subtype of bipolar disorder

Discovery could guide future treatments for patients with hypertension

Genetic risk for developing psychiatric disorders or cognitive traits manifest in brain structure from childhood

Ebola virus identified in a West African bat

Researchers uncover new role of heterochromatin in maintaining chromosomal integrity

African scientists to build research capacity in African countries, develop ongoing scientific partnerships

Old oligodendrocytes can repair damage in the brains of patients with multiple sclerosis

Ludwig researchers find ways to make resistant melanomas susceptible to immunotherapy

Unique data combination helps FinnGen researchers to fund links between genetic factors and health

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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