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Bacteria lurking in cancer cells may affect treatment

Cancer cells are comfy havens for bacteria. That conclusion arises from a rigorous study of over 1,000 tumor samples of different human cancers.

2 Jun 2020

New advance addresses a big challenge with using CRISPR in cancer patients

A mutation unique to certain cancer tumors is a potential homing beacon for safely deploying CRISPR gene editing enzymes to disarm DNA that makes cancer cells resistant to treatment, while ignoring the gene in normal cells where it's critical to healthy function, according to a new study from ChristianaCare's Gene Editing Institute in the journal Molecular Cancer Research.

2 Jun 2020

Fraunhofer researchers investigate the mechanisms of metastasis formation

What makes tumor cells turn murderous? The Fraunhofer Institute for Toxicology and Experimental Medicine ITEM is investigating the mechanisms of metastasis formation - and searching for approaches for new treatments in the fight against cancer.

2 Jun 2020

Researchers identify key protein required for optimal immune responses to cancer

A new study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Solove Research Institute (OSUCCC - James) has identified a protein within certain immune cells that is required for optimal immune responses to cancer.

2 Jun 2020

Journal publication supports Synlogic’s first clinical immuno-oncology program, SYNB1891

Synlogic, Inc., a clinical-stage company applying synthetic biology to beneficial microbes to develop novel, living medicines, today announced the publication in Nature Communications of preclinical data supporting its first clinical immuno-oncology program, SYNB1891, which is being evaluated in Phase 1 clinical trial in patients with advanced solid tumors or lymphoma.

2 Jun 2020

Blood test may predict a patient’s response to prostate cancer treatment

A team of researchers at The Institute of Cancer Research (ICR) in London found that the test can detect traces of cancer DNA in the bloodstream. The liquid biopsy could also identify the patients who are more likely to relapse.

1 Jun 2020

Study resolves contradictions surrounding p53 gene's role in pluripotent stem cell differentiation

The gene p53 is extremely important in cell biology and, hence, the world of cell replacement therapy. Its role is to regulate the cell cycle and halt the formation of tumors, leading to its nickname the "tumor suppressor gene."

1 Jun 2020

Cancer clusters' resistance to natural killer cell immunosurveillance favors metastasis

Scientific evidence suggests that cancer can metastasize to other organs when either a single cell or a cluster of cells detaches from the original tumor and travels through the blood to another location, where it grows into a new tumor.

1 Jun 2020

Researchers discover genetic cause of 'differences in sexual development'

Researchers at the Francis Crick Institute, the Institut Pasteur and their clinical collaborators have identified a cause of testicular tissue developing in people with female chromosomes.

1 Jun 2020

A moving target identified in small cell lung tumors

Lung cancers account for approximately 25 percent of all cancer deaths. Even among those who do not smoke, 1 in 15 men and 1 in 17 women are expected to develop lung cancer in their lifetime, according to the American Cancer Society.

1 Jun 2020

Study uncovers how cancer cells protect themselves from viruses

Researchers at the Francis Crick Institute have uncovered how cancer cells protect themselves from viruses that are harmful to tumors but not to healthy cells. These findings could lead to improved viral treatments for the disease.

1 Jun 2020

New MRI technique to improve tumor diagnosis

Early diagnosis of cancer is one of the highest-priority problem for the healthcare system, because it is critical for overall treatment success and saving patients' lives. DWI may be used to detect a malignancy in various tissues and organs.

1 Jun 2020

New software helps prioritize medical procedures and treat people more efficiently

Many patients had to wait for lifesaving surgeries, such as organ transplants, due to the heavy burden COVID-19 caused by hospitals.

1 Jun 2020

New immunotherapy for metastatic non-small cell lung cancer shows promise in clinical trial

A new type of immunotherapy treatment for metastatic non-small cell lung cancer (NSCLC) is being tested by Missak Haigentz, Jr., MD, medical director of hematology and oncology for Atlantic Health System.

30 May 2020

Immunotherapy doubles progression-free survival time of patients with advanced bowel cancer

A large international trial involving UCL and University College London Hospitals NHS Foundation Trust (UCLH) has found that pembrolizumab, a form of immunotherapy, more than doubled the 'progression free survival' time of patients with a specific subtype of advanced bowel cancer, when compared with chemotherapy.

30 May 2020

Scientists identify factors influencing outcomes in kidney cancer patients treated with immunotherapy

By analyzing tumors from patients treated with immunotherapy for advanced kidney cancer in three clinical trials, Dana-Farber Cancer Institute scientists have identified several features of the tumors that influence their response to immune checkpoint inhibitor drugs.

30 May 2020

Toshiba and Shinshu University jointly develop a 'tumor-tropic liposome technology' for gene therapy

Toshiba Corporation and a team led by Professor Yozo Nakazawa at the Department of Pediatrics, Shinshu University, have together developed a “tumor-tropic liposome technology” for gene therapy. The technology uses unique, nano-sized biodegradable liposomes developed by Toshiba to accurately and efficiently deliver therapeutic genes to targeted cancer cells, and achieves safer gene delivery than viruses used as carriers.

30 May 2020

Study solves the longstanding mystery of anesthesia

Surgery would be inconceivable without general anesthesia, so it may come as a surprise that despite its 175-year history of medical use, doctors and scientists have been unable to explain how anesthetics temporarily render patients unconscious.

30 May 2020

Clinical trial shows anti-tumor responses in metastatic castration-resistant prostate cancer patients

The preliminary results of a Phase I clinical trial conducted by researchers at the Yale Cancer Center have shown that ARV-110, an androgen receptor PROTAC protein degrader, demonstrates clinical evidence of anti-tumor responses in patients with metastatic castration-resistant prostate cancer (mCRPC) who have failed prior therapy.

29 May 2020

Monoclonal antibody therapy achieves modest reduction in recurrence for patients with HER2-positive DCIS

The addition of the monoclonal antibody therapy Trastuzumab to radiotherapy did not reach the protocol objective of a 36% reduction in the ipsilateral breast tumor recurrence rate for women with HER2-positive ductal carcinoma in situ (DCIS) on the NRG Oncology clinical trial NSABP B-43.

29 May 2020

Tumor News and Research

Bacteria lurking in cancer cells may affect treatment

New advance addresses a big challenge with using CRISPR in cancer patients

Fraunhofer researchers investigate the mechanisms of metastasis formation

Researchers identify key protein required for optimal immune responses to cancer

Journal publication supports Synlogic’s first clinical immuno-oncology program, SYNB1891

Blood test may predict a patient’s response to prostate cancer treatment

Study resolves contradictions surrounding p53 gene's role in pluripotent stem cell differentiation

Cancer clusters' resistance to natural killer cell immunosurveillance favors metastasis

Researchers discover genetic cause of 'differences in sexual development'

A moving target identified in small cell lung tumors

Study uncovers how cancer cells protect themselves from viruses

New MRI technique to improve tumor diagnosis

New software helps prioritize medical procedures and treat people more efficiently

New immunotherapy for metastatic non-small cell lung cancer shows promise in clinical trial

Immunotherapy doubles progression-free survival time of patients with advanced bowel cancer

Scientists identify factors influencing outcomes in kidney cancer patients treated with immunotherapy

Toshiba and Shinshu University jointly develop a 'tumor-tropic liposome technology' for gene therapy

Study solves the longstanding mystery of anesthesia

Clinical trial shows anti-tumor responses in metastatic castration-resistant prostate cancer patients

Monoclonal antibody therapy achieves modest reduction in recurrence for patients with HER2-positive DCIS

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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