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Successful gene therapy trial in patients with X-linked Chronic Septic Granulomatosis

American and British teams led by Drs Kohn (University of California, Los Angeles), Malech (NIH), Williams (Boston Children's) and Trasher (Great Ormond Street Institute of Child Health) published yesterday in Nature Medicine the conclusive results of a gene therapy trial conducted in the United States and Great Britain in 9 patients with X-linked Chronic Septic Granulomatosis (X-CGD), a rare and severe immune dysfunction. Six of them are free of treatment for complications generated by the disease.

28 Jan 2020

The challenge of new antibiotic discovery

It is important to discover antibiotic drugs and to bring them to clinical use, a task made all the more urgent by the increase in the number of infections that are resistant to existing antibiotics. However, this task is a formidable one.

28 Jan 2020

Weight loss surgery helps reverse respiratory issues in obese patients

Obesity is now considered a global health epidemic, affecting millions of people worldwide. In morbidly obese patients, the extra weight has taken a toll on their overall health, including predisposing them to cardiovascular disease, type 2 diabetes, certain cancers, and respiratory issues. However, breathing issues in obese people may be reversed and relieved, thanks to weight loss surgery.

28 Jan 2020

PCORI Board of Governors approve $12.2 million to find ways to treat different health conditions

The Patient-Centered Outcomes Research Institute Board of Governors today approved $12.2 million to fund four studies comparing the most effective ways to treat a range of health conditions that impose high burdens on patients, their families and the healthcare system.

28 Jan 2020

NIU professor gets $372,500 to study link between brain health and exercise

Angela Grippo's New Year's resolution is exercise, exercise, exercise, but the Northern Illinois University psychology professor won't be breaking a sweat or hitting the gym.

28 Jan 2020

Research provides insights about sex- and gender-specific aspects of medicine

At present, a focus on males in basic research and clinical trials means that models of disease are also based on men. Symptoms and disease progression in male patients are therefore considered the standard, while disease manifestations that are usually observed in women are judged "atypical".

28 Jan 2020

Study offers significant promise for treating an aspect of schizophrenia

Research by a University of Georgia psychologist shows that targeting one particular symptom of schizophrenia has a positive effect on other symptoms, offering significant promise for treating an aspect of schizophrenia that currently has no pharmaceutical options.

28 Jan 2020

Novel palladium compound acts against ovarian tumor cells

A group led by a researcher affiliated with the University of São Paulo's São Carlos Chemistry Institute (IQSC-USP) in Brazil has developed a novel palladium compound that acts against ovarian tumor cells without affecting healthy tissues. Palladium is a silvery white metal belonging to the same group as platinum.

28 Jan 2020

Chan Zuckerberg Initiative announces over $1.3 million to support Global BioImaging

Today, the Chan Zuckerberg Initiative announced over $1.3 million in funding to support Global BioImaging, an international network of bioimaging facilities and communities.

28 Jan 2020

Findings shed new light on how striatum processes information to plan, execute movements

Researchers at Karolinska Institutet have mapped how different nerve cells in the brain area striatum process information to plan and execute our movements at just the right time and with the right vigour. The results, presented in the journal Cell Reports, show that different cell types in the striatum receive signals from completely different parts of the cerebral cortex and thus respond to different types of information.

28 Jan 2020

Response to nation’s 1st coronavirus case draws on lessons from measles outbreak

When the first U.S. case of a new coronavirus spreading throughout China was confirmed last week in Washington state, public health workers were well prepared to respond, building on lessons learned during the outbreak of measles that sickened 87 people in the state in 2019.

28 Jan 2020

Study could lead to next-generation clinical testing for hidden hearing loss

A pair of biomarkers of brain function -- one that represents "listening effort," and another that measures ability to process rapid changes in frequencies -- may help to explain why a person with normal hearing may struggle to follow conversations in noisy environments, according to a new study led by Massachusetts Eye and Ear researchers.

28 Jan 2020

QUT forum to address Australia's catastrophic fire season

Is it possible to create a truly bushfire-resistant house? What's the best way to donate to bushfires? How can you tell fact from fake news in this era of Twitter bots? How can we improve communication to save lives and property? These and more questions will be on the table at an important forum at QUT this Friday addressing Australia's catastrophic fire season.

28 Jan 2020

Zinc acetate lozenges did not reduce duration of common cold in randomized trial

Administration of zinc acetate lozenges to common cold patients did not shorten colds in a randomized trial published in BMJ Open.

28 Jan 2020

Researchers discover how CDK8 oncogene gets activated in healthy humans

Most cancers are caused by a large variety of factors that vary from one person to another. To unravel this complexity, genes that contribute to the development of a respective cancer must be identified. Such genes are called oncogenes. A good example of an oncogene is CDK8: Cyclin-dependent kinase 8.

28 Jan 2020

Experts identify cities most at risk from global spread of Coronavirus

Experts in population mapping at the University of Southampton have identified cities and provinces within mainland China, and cities and countries worldwide, which are at high-risk from the spread of the 2019 Novel Coronavirus (2019-nCoV).

28 Jan 2020

Study advances understanding of relation between intergroup contact and social change

For more than 50 years, social scientists and practitioners have suggested that having members of different groups interact with each other can be an effective tool for reducing prejudice.

28 Jan 2020

New study of genes in Asian populations may help better understand, treat genetic diseases

An ambitious new study of genes in Asian populations is filling in big gaps in our understanding of human genetics, shedding light on the history of human migration and ultimately aiming to improve our ability to treat disease.

28 Jan 2020

Non-invasive electrostimulation of the vagus nerve improves memory in mice

Researchers at UPF are testing a new non-invasive method of stimulating the vagus nerve in mice that improves their memory.

28 Jan 2020

Researchers succeed in creating complex pattern of hives

Hives afflict 1 in 5 people, but the exact mechanisms behind the itchy red rashes are not well known. The research team studied the patterns of hives in patients and reproduced the hive patterns using a mathematical model called a reaction-diffusion model, a common prototype for understanding how patterns develop. The researchers' model is a single equation type which had never before been used to generate complex patterns.

28 Jan 2020

Research News and Research

Successful gene therapy trial in patients with X-linked Chronic Septic Granulomatosis

The challenge of new antibiotic discovery

Weight loss surgery helps reverse respiratory issues in obese patients

PCORI Board of Governors approve $12.2 million to find ways to treat different health conditions

NIU professor gets $372,500 to study link between brain health and exercise

Research provides insights about sex- and gender-specific aspects of medicine

Study offers significant promise for treating an aspect of schizophrenia

Novel palladium compound acts against ovarian tumor cells

Chan Zuckerberg Initiative announces over $1.3 million to support Global BioImaging

Findings shed new light on how striatum processes information to plan, execute movements

Response to nation’s 1st coronavirus case draws on lessons from measles outbreak

Study could lead to next-generation clinical testing for hidden hearing loss

QUT forum to address Australia's catastrophic fire season

Zinc acetate lozenges did not reduce duration of common cold in randomized trial

Researchers discover how CDK8 oncogene gets activated in healthy humans

Experts identify cities most at risk from global spread of Coronavirus

Study advances understanding of relation between intergroup contact and social change

New study of genes in Asian populations may help better understand, treat genetic diseases

Non-invasive electrostimulation of the vagus nerve improves memory in mice

Researchers succeed in creating complex pattern of hives

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