Efficacy News and Research

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Antibody response induced by mRNA vaccination differs from natural SARS-CoV-2 infection

Researchers tested the antibodies elicited from mRNA vaccination and compared them to those from natural SARS-CoV-2 infection. They found the vaccine did not have antibodies to the virus nucleocapsid protein but had potent RBD antibodies.

21 Apr 2021

New efforts to improve the efficacy of nucleotide-based drugs against prostate cancer, bone metastasis

Published in the Advanced Functional Materials, University of Minnesota researcher Hongbo Pang led a cross-institutional study on improving the efficacy of nucleotide-based drugs against prostate cancer and bone metastasis.

21 Apr 2021

Researchers reveal a potential therapeutic strategy against T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive type of leukemia in which too many T-cell lymphoblasts, or immature white blood cells, are found in the bone marrow and blood.

20 Apr 2021

Genethon announces dosing of first patient at pediatric clinical trial platform for neuromuscular diseases

A first participant was dosed at I-Motion, the pediatric clinical trial platform for neuromuscular diseases located at Trousseau hospital in Paris, as part of the gene therapy trial in Duchenne muscular dystrophy (DMD) conducted by Genethon.

20 Apr 2021

Study evaluates stem cells' ability to prevent major cause of death in preterm infants

A phase 2 clinical trial whose results were released today in STEM CELLS Translational Medicine might point to a way to overcome bronchopulmonary dysplasia (BPD), a major cause of death in preterm infants.

20 Apr 2021

Probiotic L. acidophilus can effectively treat intestinal inflammation, research shows

Intestinal epithelial tight junctions (TJs) act as a functional and structural barrier against harmful antigens that promote intestinal inflammation in inflammatory bowel disease (IBD) and other inflammatory conditions of the gut.

20 Apr 2021

Chronic SARS-CoV-2 infections favor viral adaptation, says study

A new study offers a look at how to keep these hopes alive in the current context of highly infectious variants, which often display immune escape mutations.

20 Apr 2021

Limited SARS-CoV-2 spread in childcare centers, finds study

A new study adds to the sum of evidence that children do not play a key role in the transmission of the SARS-CoV-2, the pathogen behind the current pandemic of COVID-19.

20 Apr 2021

Humoral immunity developed by DNA vaccine INO-4800 is effective against SARS-CoV-2 variants

A team of international scientists recently demonstrated that antibodies generated in response to the DNA vaccine INO-4800 can effectively neutralize some of the recently emerged variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), such as G614, 501Y.V1, and 501Y.V2.

20 Apr 2021

Can fingerprick blood tests help evaluate antibody response and longevity against SARS-CoV-2 post-vaccination?

To monitor antibody level duration of vaccine-induced immune responses, a team of researchers in the U.S. – at Diacarta, University of California and VA Healthcare System, and the Franciscan University of Steubenville – evaluated the feasibility of using a single drop of fingerstick blood collected with flocked swabs for quantitative antibody response evaluation after COVID-19 vaccination.

20 Apr 2021

New nanomedicine device is effective for treating glioblastoma multiforme

A micro-sized polymeric net wrapping around brain tumors, just like a fishing net around a shoal of fish: this is the microMESH, a new nanomedicine device capable to conform around the surface of tumor masses and efficiently deliver drugs.

20 Apr 2021

Screening drug candidates for COVID-19 treatment using computational methods

Researchers identified two potential drug candidates that can inhibit SARS-CoV-2 in vitro. Their combination can work synergistically and increase their inhibitory effect.

19 Apr 2021

Sinovac COVID-19 vaccine shows 50% effectiveness in a cohort of Brazilian healthcare workers

CoronaVac is a well-tolerated vaccine containing inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and it induced humoral responses in phase 1 and 2 studies. Analysis of a Brazilian phase 3 clinical trial that evaluated 12,607 participants showed that the vaccine had an efficacy of 50.39% 15 days after the 2nd dose.

19 Apr 2021

Researchers show how to evaluate waning efficacy of COVID-19 vaccines

Researchers in the United States have demonstrated how to estimate the potentially waning efficacy of vaccines designed to protect against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

19 Apr 2021

COVID-19 pandemic has created major changes in delivery of MS care

A survey of U.S. multiple sclerosis, or MS, specialist clinicians reveals the COVID-19 pandemic has created major changes in how they deliver care.

19 Apr 2021

Once-a-week injectable insulin therapy proves to be safe, effective in people with Type 2 diabetes

Treating people with Type 2 diabetes with a new once-a-week injectable insulin therapy proved to be safe and as effective as daily insulin injections, according to the results of two international clinical trials published online today in Diabetes Care.

19 Apr 2021

Gene therapy for common forms of congenital blindness shows promise to improve vision

A new gene therapy for one of the most common forms of congenital blindness was safe and improved patients' vision, according to initial data from a clinical trial led by researchers at the Scheie Eye Institute in the Perelman School of Medicine at the University of Pennsylvania.

19 Apr 2021

Study assess prevalence of SARS-CoV-2 in England after third national lockdown

In a new study, the REACT-1 research group offer their findings on the rate of SARS-CoV-2 infection in England after the country went into a third national lockdown. Their findings show a 60% reduction of incidence from their previous round of surveillance.

19 Apr 2021

USP7 inhibitors could increase the anticancer effects of CDK1 compounds in cancer patients

Understanding the components that control cell division is fundamental to understanding how life works and how alterations in this delicate process can cause diseases such as cancer.

19 Apr 2021

The shock and reality of catching Covid after being vaccinated

Robin Hauser, a pediatrician in Tampa, Fla., got covid in February. What separates her from the vast majority of the tens of millions of other Americans who have come down with the virus is this: She got sick seven weeks after her second dose of the Pfizer-BioNTech vaccine.

17 Apr 2021

Efficacy News and Research

Antibody response induced by mRNA vaccination differs from natural SARS-CoV-2 infection

New efforts to improve the efficacy of nucleotide-based drugs against prostate cancer, bone metastasis

Researchers reveal a potential therapeutic strategy against T-cell acute lymphoblastic leukemia

Genethon announces dosing of first patient at pediatric clinical trial platform for neuromuscular diseases

Study evaluates stem cells' ability to prevent major cause of death in preterm infants

Probiotic L. acidophilus can effectively treat intestinal inflammation, research shows

Chronic SARS-CoV-2 infections favor viral adaptation, says study

Limited SARS-CoV-2 spread in childcare centers, finds study

Humoral immunity developed by DNA vaccine INO-4800 is effective against SARS-CoV-2 variants

Can fingerprick blood tests help evaluate antibody response and longevity against SARS-CoV-2 post-vaccination?

New nanomedicine device is effective for treating glioblastoma multiforme

Screening drug candidates for COVID-19 treatment using computational methods

Sinovac COVID-19 vaccine shows 50% effectiveness in a cohort of Brazilian healthcare workers

Researchers show how to evaluate waning efficacy of COVID-19 vaccines

COVID-19 pandemic has created major changes in delivery of MS care

Once-a-week injectable insulin therapy proves to be safe, effective in people with Type 2 diabetes

Gene therapy for common forms of congenital blindness shows promise to improve vision

Study assess prevalence of SARS-CoV-2 in England after third national lockdown

USP7 inhibitors could increase the anticancer effects of CDK1 compounds in cancer patients

The shock and reality of catching Covid after being vaccinated

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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