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Genetic mutation may increase susceptibility to cytomegalovirus infection

Experimenting with human cells and mice, Johns Hopkins researchers have found that a genetic mutation that alters a protein called NOD1 may increase susceptibility to human cytomegalovirus (CMV) infection.

20 Dec 2016

Active ingredient of pungent substances slows growth of breast cancer cells

Capsaicin, an active ingredient of pungent substances such as chilli or pepper, inhibits the growth of breast cancer cells.

20 Dec 2016

Bioinformatics helps identify new, untested drug combinations for treatment of breast cancer

Based on the study of cell signalling networks, the cell signals that drugs alter when they reach their target molecule, an exhaustive in silico analysis of the pairing of 64 therapeutic agents used to treat breast cancer (half already in use and the other half in clinical testing phase) has allowed researchers at the Institute for Research in Biomedicine to identify 10 new and previously untested combinations that hold potential for the treatment of breast cancer.

20 Dec 2016

TSRI scientists develop new methods to design precision medicines against disease-causing RNAs

Scientists on the Florida campus of The Scripps Research Institute have developed broad methods to design precision medicines against currently incurable diseases caused by RNA.

20 Dec 2016

Study identifies four previously unknown genetic risk locations for primary sclerosing cholangitis

A study of unprecedented scale has led researchers to identify four previously unknown genetic risk locations for primary sclerosing cholangitis, a liver disease that lacks effective medical therapy.

20 Dec 2016

Researchers use CRISPR-based genetic screening to identify three promising HIV treatment targets

Investigators from Whitehead Institute, the Ragon Institute of MGH, MIT and Harvard and the Broad Institute of MIT and Harvard have used CRISPR-Cas9 gene-editing technology to identify three promising new targets for treatment of HIV infection.

20 Dec 2016

Landmark clinical trial to test third investigational drug for Alzheimer's disease

An international team led by Washington University School of Medicine in St. Louis has selected a third investigational drug to be tested in a worldwide clinical trial - already underway - aimed at finding treatments to prevent Alzheimer's disease.

20 Dec 2016

Ancient Chinese medicine for malaria could potentially aid in treatment of tuberculosis

A centuries-old herbal medicine, discovered by Chinese scientists and used to effectively treat malaria, has been found to potentially aid in the treatment of tuberculosis and may slow the evolution of drug resistance.

19 Dec 2016

Sirt1 plays key role in regenerating glial progenitor cells after hypoxia-induced brain injury in preemies

Developing brains in newborns have a sizable pool of a certain type of immature progenitor cell that can be expanded and induced to replace cells lost to brain injury.

19 Dec 2016

Scientists discover mechanism that hijacks immune system's response to tuberculosis

Scientists have discovered the mechanism that hijacks the immune system's response to tuberculosis, revealing an important new drug target for the disease that kills more than 1 million people each year.

17 Dec 2016

Scientists discover how COPD patients' lungs lose ability to repair damages

In chronic obstructive pulmonary disease (COPD), the patients' lungs lose their ability to repair damages on their own.

16 Dec 2016

Researchers find new insights into silencing of X-chromosomes in human embryos

Researchers have discovered new insights into how one of the two X-chromosomes is silenced during the development of female human embryos and also in lab-grown stem cells.

16 Dec 2016

Study suggests revolutionary way to make cancer cells more susceptible to existing chemotherapies

The same signal that drives aggressive growth in a deadly cancer cell type also triggers coping mechanisms that make it "notoriously" hard to kill, according to a study published online December 15 in Cell. When stressed, this cell type - far more than most cancer cells - encases its genetic messages in protein globs called "stress granules" that lessen the effect of chemotherapies.

16 Dec 2016

Researchers develop promising therapeutic antibodies against tumor-promoting MMPs

Researchers at the University of California, Riverside have camels and llamas to thank for their development of a new cancer treatment that is highly selective in blocking the action of faulty matrix metalloproteinases (MMPs).

16 Dec 2016

Researchers identify attractive drug candidate to target glioma tumors

In a paper published today in Cancer Research, researchers: 1) identify a biomarker enzyme associated with aggressive glioma brain tumors, 2) reveal the regulatory mechanism for that enzyme, and 3) demonstrate potent efficacy, using a mouse model of glioma, for a small molecule inhibitor they have developed.

16 Dec 2016

Molecule News and Research

Genetic mutation may increase susceptibility to cytomegalovirus infection

Active ingredient of pungent substances slows growth of breast cancer cells

Bioinformatics helps identify new, untested drug combinations for treatment of breast cancer

TSRI scientists develop new methods to design precision medicines against disease-causing RNAs

Study identifies four previously unknown genetic risk locations for primary sclerosing cholangitis

Researchers use CRISPR-based genetic screening to identify three promising HIV treatment targets

Landmark clinical trial to test third investigational drug for Alzheimer's disease

Ancient Chinese medicine for malaria could potentially aid in treatment of tuberculosis

Sirt1 plays key role in regenerating glial progenitor cells after hypoxia-induced brain injury in preemies

Scientists discover mechanism that hijacks immune system's response to tuberculosis

Scientists discover how COPD patients' lungs lose ability to repair damages

Researchers find new insights into silencing of X-chromosomes in human embryos

Study suggests revolutionary way to make cancer cells more susceptible to existing chemotherapies

Researchers develop promising therapeutic antibodies against tumor-promoting MMPs

Researchers identify attractive drug candidate to target glioma tumors

Lab-based cellular tests reveal that e-cigarette vapour does not induce DNA damage

Scientists discover new class of host molecules to transport steroids in the body

New duo therapy offers hope for 'super blockage' of over-active immune system

Scientists explain concept of combining NO gas therapy with starvation of tumor cells for nanomedical treatment

Research into common congenital brain defect identifies molecular basis

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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