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Mayo Clinic, Geroscience Network researchers aim to accelerate pace of aging research

Mayo Clinic, along with other members of the Geroscience Network, has published six manuscripts that map strategies for taking new drugs that target processes underlying aging into clinical trials.

17 Aug 2016

Scientists examine how neural responses change over time in patients with Parkinson's disease

Neuroscientists peered into the brains of patients with Parkinson's disease and two similar conditions to see how their neural responses changed over time.

16 Aug 2016

Newfound role for PARP proteins could lead to therapeutic opportunities for cancer

Using technology they developed, UT Southwestern Medical Center researchers have identified a previously unknown role of a certain class of proteins: as regulators of gene activity and RNA processing.

16 Aug 2016

Former SpaceX engineers launch Synthego, CRISPRevolution to accelerate genome engineering research

Synthego, a leading provider of genome engineering solutions, officially launches today. Synthego’s flagship product line, CRISPRevolution, features synthetic guide RNA products designed to accelerate CRISPR/Cas9 and Cpf1 genome engineering research. CRISPRevolution is the first product line to offer economical access to fully synthetic RNA for high fidelity editing and increased precision in genome editing.

12 Aug 2016

RACP releases new Choosing Wisely Australia recommendations on appropriate use of medicines for older adults

The latest lists developed by specialties from the Royal Australasian College of Physicians as part of the Choosing Wisely Australia initiative deliver a strong message on appropriate use of medicines for older Australians.

12 Aug 2016

FDA grants Orphan Drug Designation to CD4CAR therapy for treatment of peripheral T-cell lymphoma

iCell Gene Therapeutics today (Aug. 11) announced that the Food and Drug Administration has granted Orphan Drug Designation for its chimeric antigen receptor engineered T-cells directed against the target protein CD4 (CD4CAR) for the treatment of peripheral T-cell lymphoma (PTCL).

12 Aug 2016

Study provides detailed picture of genetics underlying type 2 diabetes

The largest study of its kind into type 2 diabetes has produced the most detailed picture to date of the genetics underlying the condition.

12 Aug 2016

Scientists identify potential mechanism that paves way for improved treatment of fungal infections

By identifying new compounds that selectively block mitochondrial respiration in pathogenic fungi, Whitehead Institute scientists have identified a potential antifungal mechanism that could enable combination therapy with fluconazole, one of today's most commonly prescribed fungal infection treatments.

11 Aug 2016

Researchers develop new strategy to convert fibroblasts directly into neuronal cells

Researchers have used CRISPR -- a revolutionary new genetic engineering technique -- to convert cells isolated from mouse connective tissue directly into neuronal cells.

11 Aug 2016

Scientists provide new insights into workings of cancer-linked potassium channel

Most cells in the body carry on their surface tiny pores through which potassium ions travel. In controlling the flow of these positively charged ions, the channel helps the cell maintain its electrical balance.

11 Aug 2016

Researchers find causal link between senescent cells and age-related osteoarthritis

Researchers at Mayo Clinic have reported a causal link between senescent cells — cells that accumulate with age and contribute to frailty and disease — and osteoarthritis in mice.

11 Aug 2016

Scientists link malfunctioning molecular pathways to specific heart abnormalities in SCA

Patients with sickle cell anemia (SCA) develop heart complications and nearly a quarter die a sudden death. Now, researchers have linked malfunctioning molecular pathways to specific heart anomalies in SCA that result from progressive fibrosis and result in sudden death.

9 Aug 2016

TSRI scientists zoom in to view how experimental therapy ZMapp targets Ebola virus

Scientists at The Scripps Research Institute now have a high-resolution view of exactly how the experimental therapy ZMapp targets Ebola virus.

9 Aug 2016

New laboratory model replicates early phase of Parkinson's before onset of motor symptoms

They're two of the biggest mysteries in Parkinson's disease research--where does the disease start? And how can it be stopped early in the process? Now, a new laboratory model of Parkinson's is giving scientists an inside look at what happens in the brain years before motor symptoms appear.

9 Aug 2016

Immunotherapy innovations in oncology: an interview with Robert LaCaze

The body’s immune system is an excellent weapon against many diseases. For more than 100 years, immunology and immunotherapy have played an ever-increasing role in the understanding and treatment of cancer.

8 Aug 2016

UM SOM selected as study site for human safety trial of new Zika vaccine

As world leaders increasingly recognize the Zika virus as an international public health threat, the Center for Vaccine Development at the University of Maryland School of Medicine's Institute for Global Health has been chosen as one of three study sites in a human safety trial of a new Zika vaccine.

7 Aug 2016

NIH launches clinical trial of experimental vaccine candidate for preventing Zika virus infection

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, has launched a clinical trial of a vaccine candidate intended to prevent Zika virus infection.

3 Aug 2016

GW researchers identify new way to regulate chronic toxoplasmosis

New research critical to treatment for chronic toxoplasmosis, one of the most common parasitic diseases worldwide, was published in the Journal of Experimental Medicine.

2 Aug 2016

TSRI study unveils new twist in immune biology

A new study, led by scientists at The Scripps Research Institute, reveals a surprising twist in immune biology.

2 Aug 2016

Overcoming gene silencing barriers to target neurological conditions: an interview with Dr Errol de Souza

Many gene mutations that cause neurological disorders have been identified. For example, in a rare neurological disorder such as Huntington’s disease, an autosomal dominant mutation through expansion of CAG (cytosine-adenine-guanine) triplet repeats in the gene coding for the Huntingtin protein results in abnormal protein production.

1 Aug 2016

Therapeutics News and Research

Mayo Clinic, Geroscience Network researchers aim to accelerate pace of aging research

Scientists examine how neural responses change over time in patients with Parkinson's disease

Newfound role for PARP proteins could lead to therapeutic opportunities for cancer

Former SpaceX engineers launch Synthego, CRISPRevolution to accelerate genome engineering research

RACP releases new Choosing Wisely Australia recommendations on appropriate use of medicines for older adults

FDA grants Orphan Drug Designation to CD4CAR therapy for treatment of peripheral T-cell lymphoma

Study provides detailed picture of genetics underlying type 2 diabetes

Scientists identify potential mechanism that paves way for improved treatment of fungal infections

Researchers develop new strategy to convert fibroblasts directly into neuronal cells

Scientists provide new insights into workings of cancer-linked potassium channel

Researchers find causal link between senescent cells and age-related osteoarthritis

Scientists link malfunctioning molecular pathways to specific heart abnormalities in SCA

TSRI scientists zoom in to view how experimental therapy ZMapp targets Ebola virus

New laboratory model replicates early phase of Parkinson's before onset of motor symptoms

Immunotherapy innovations in oncology: an interview with Robert LaCaze

UM SOM selected as study site for human safety trial of new Zika vaccine

NIH launches clinical trial of experimental vaccine candidate for preventing Zika virus infection

GW researchers identify new way to regulate chronic toxoplasmosis

TSRI study unveils new twist in immune biology

Overcoming gene silencing barriers to target neurological conditions: an interview with Dr Errol de Souza

Industry Focus eBook - Microbiome (1st edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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