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New three-dimensional map of cystic fibrosis protein offers new insights to treating fatal disease

Rockefeller scientists have created the first three-dimensional map of the protein responsible for cystic fibrosis, an inherited disease for which there is no cure.

1 Dec 2016

Duke researchers modify popular drug-delivery technology to evade immune responses

Biomedical engineers at Duke University have reconfigured a popular drug-delivery technology to evade immune responses that have halted some clinical trials.

1 Dec 2016

Researchers develop efficient computational method to create new drugs

Researchers of the University of Barcelona have developed a more efficient computational method to identify new drugs.

1 Dec 2016

Researchers identify metabolite that promotes epithelial-mesenchymal transition of colorectal cancer cells

Osaka University researchers revealed that the metabolite D-2-hydroxyglurate (D-2HG) promotes epithelial-mesenchymal transition of colorectal cancer cells, leading them to develop features of lower adherence to neighboring cells, increased invasiveness, and greater likelihood of metastatic spread.

1 Dec 2016

Scientists synthesize antitumor compound to combat chemoresistant cancer

A team of scientists from N. D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences, N. K. Kol'tsov Institute of Developmental Biology of the RAS, and Immune Pharmaceuticals LLC led by MIPT's Prof. Alexander Kiselyov has synthesized an antitumor compound that could be used to fight chemoresistant cancer.

30 Nov 2016

Scientists identify cell-surface receptor for progranulin

Progranulin is produced and secreted by most cells in the body. From skin to immune cells, brain to bone marrow cells, progranulin plays a key role in maintaining normal cellular function.

30 Nov 2016

Researchers use microbubbles and ultrasound to transport drugs across blood–brain barrier

The impassable blood-brain barrier prevents microorganisms from entering our brain, however it also blocks medicines that could help treat Parkinson's, Alzheimer's and other neurodegenerative diseases.

30 Nov 2016

NUS study offers new hope for treating aggressive ovarian cancer subtype

A recent discovery by researchers from the Cancer Science Institute of Singapore at the National University of Singapore may lead to a new treatment strategy for an aggressive ovarian cancer subtype.

30 Nov 2016

Okayama University researchers find way to prevent replication of influenza viral RNA

Researchers at Okayama University have successfully cleaved influenza viral RNA to prevent its replication using novel artificial RNA restriction enzymes in laboratory cell cultures.

30 Nov 2016

Researchers find way to make changes to enzyme-driven assembly line to improve antibiotics

Researchers from North Carolina State University have discovered a way to make pinpoint changes to an enzyme-driven "assembly line" that will enable scientists to improve or change the properties of existing antibiotics as well as create designer compounds.

30 Nov 2016

OmniPath provides gateway for literature-curated signalling pathways with unprecedented accuracy

Combining the power of 27 data resources, Omnipath helps researchers see biological signalling pathways with unprecedented accuracy.

29 Nov 2016

Dirt beneath New York City may provide new weapons to fight against disease

Microbes have long been an invaluable source of new drugs. And to find more, we may have to look no further than the ground beneath our feet.

29 Nov 2016

TUM scientists uncover molecular mechanisms of inhibitors that can selectively thwart immunoproteasome

The immunoproteasome dismantles proteins and the resulting fragments are displayed on the surface of cells. This helps the immune system to recognize abnormal cells. However, in chronic inflammations and autoimmune diseases this “information channel” is overactive.

29 Nov 2016

Tissue damage plays crucial role in cell reprogramming

Cell reprogramming does not happen exactly as we thought. In the pages of the journal Science, a team from the Spanish National Cancer Research Centre has shown that tissue damage is a relevant factor for cells to go back to an embryonic state.

24 Nov 2016

Researchers engineer cells with 'built-in genetic circuit' that can inhibit tumour growth

Researchers at the University of Southampton have engineered cells with a 'built-in genetic circuit' that produces a molecule that inhibits the ability of tumours to survive and grow in their low oxygen environment.

24 Nov 2016

Karolinska Institute biologist receives 2016 Naomi Berrie Award for excellence in diabetes research

Columbia University has awarded the 2016 Naomi Berrie Award for Outstanding Achievement in Diabetes Research to Peter Arner, MD, PhD, a Distinguished Professor in the Department of Medicine at the Karolinska Institute, whose studies on the turnover of fat tissue in the human body has revealed processes that contribute to obesity and diabetes.

23 Nov 2016

Pro-growth cancer signaling pathway could light up new avenues of treatments for solid tumors

Researchers from the University of Wisconsin School of Medicine and Public Health and Carbone Cancer Center have better defined a pro-growth signaling pathway common to many cancers that, when blocked, kills cancer cells but leaves healthy cells comparatively unharmed.

23 Nov 2016

Molecule News and Research

New three-dimensional map of cystic fibrosis protein offers new insights to treating fatal disease

Duke researchers modify popular drug-delivery technology to evade immune responses

Researchers develop efficient computational method to create new drugs

Researchers identify metabolite that promotes epithelial-mesenchymal transition of colorectal cancer cells

Scientists synthesize antitumor compound to combat chemoresistant cancer

Scientists identify cell-surface receptor for progranulin

Researchers use microbubbles and ultrasound to transport drugs across blood–brain barrier

NUS study offers new hope for treating aggressive ovarian cancer subtype

Okayama University researchers find way to prevent replication of influenza viral RNA

Researchers find way to make changes to enzyme-driven assembly line to improve antibiotics

OmniPath provides gateway for literature-curated signalling pathways with unprecedented accuracy

Dirt beneath New York City may provide new weapons to fight against disease

TUM scientists uncover molecular mechanisms of inhibitors that can selectively thwart immunoproteasome

Tissue damage plays crucial role in cell reprogramming

Researchers engineer cells with 'built-in genetic circuit' that can inhibit tumour growth

Karolinska Institute biologist receives 2016 Naomi Berrie Award for excellence in diabetes research

Pro-growth cancer signaling pathway could light up new avenues of treatments for solid tumors

Molecular chameleons can help track formation of bacterial biofilms

New vaccine shows potential to decrease risk of fatal opioid overdose

New imaging tool helps study toxicity of proteins linked to Alzheimer's and Parkinson's diseases

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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