Therapeutics News and Research

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Researchers discover novel neuroprotection strategies to slow progression of Parkinson's disease

Using a robust model for Parkinson's disease, University of Alabama at Birmingham researchers and colleagues have discovered an interaction in neurons that contributes to Parkinson's disease, and they have shown that drugs now under development may block the process.

20 Jul 2016

New research delves into physical properties of nanoparticles for successful drug delivery

Nanoparticles are being studied as drug delivery systems to treat a wide variety of diseases. New research delves into the physical properties of nanoparticles that are important for successfully delivering therapeutics within the body, with a primary focus on size.

19 Jul 2016

Identifying new pathway of EZH2 gene may lead to targeted therapies for aggressive breast cancer

Scientists from A*STAR's Genome Institute of Singapore and the Cancer Science Institute of Singapore at the National University of Singapore came together to understand how EZH2, a cancer-promoting gene which is known to be involved in many types of cancers, is activated in breast cancer and lymphomas.

19 Jul 2016

Scientists develop new way to resurface arthritic hip joint

With a goal of treating worn, arthritic hips without extensive surgery to replace them, scientists have programmed stem cells to grow new cartilage on a 3-D template shaped like the ball of a hip joint.

19 Jul 2016

Low-FODMAP rye bread may reduce symptoms of IBS

Patients with irritable bowel syndrome (IBS) are often concerned that certain foods may trigger or worsen their symptoms, which can include abdominal pain, diarrhea, or constipation. In a new study, patients who ate rye bread that was low in so-called "FODMAPs" (fermentable oligo- di- and mono-saccharides and polyols) experienced milder IBS symptoms than patients who ate normal rye bread.

18 Jul 2016

Study produces most detailed picture to date of genetics underlying type 2 diabetes

The largest study of its kind into type 2 diabetes has produced the most detailed picture to date of the genetics underlying the condition.

18 Jul 2016

Scientists discover improved method for large scale production of human stem cells

Scientists have discovered a new method of creating human stem cells which could solve the big problem of the large-scale production needed to fully realise the potential of these remarkable cells for understanding and treating disease.

14 Jul 2016

Sugar-binding protein galectin-9 could be new weapon to fight HIV

The ultimate impediment to a cure for HIV infection is the presence of latent, HIV-infected cells, which can reawaken and produce new virus when antiretroviral drug therapy is stopped.

13 Jul 2016

Antibodies from survivors of filovirus infection may offer protection against other filoviral diseases

Ebola and Marburg filovirus disease outbreaks have typically occurred as isolated events, confined to central Africa.

13 Jul 2016

New multicomponent reactions to develop active compounds against sleeping sickness

Multicomponent reactions are protocols that ease the chemical synthesis of new compounds, and are particularly important to gain molecules with biological activity as therapeutic agents against several pathogens.

13 Jul 2016

Research findings unveil new avenues to monitor, treat lung cancer more effectively

A team of researchers from Singapore has discovered a class of small RNA molecules, known as oncomiRs, which are responsible for fuelling lung cancer.

12 Jul 2016

Aelan's researchers develop novel epigenetic biomarker for diagnosis of AD

Aelan Cell Technologies today announced the development of a novel epigenetic biomarker. An early human clinical feasibility study has indicated that serological tests using the biomarker alongside other proprietary components developed by Aelan's researchers could potentially help physicians diagnose Alzheimer's disease (AD).

12 Jul 2016

Scientists develop new online open-access data tool to improve drug safety

A new online open-access database has been developed by scientists to allow the clinical responses of more than 5 million patients to all FDA-approved drugs to be used to identify unexpected clinical harm, benefits and alternative treatment choices for individual patients, according to a study appearing July 8 in Nature Biotechnology.

10 Jul 2016

Moffitt researchers discover novel way to control SETDB1 protein upregulated in cancer

Cancer is a group of more than 100 different diseases. All are driven by cells and genes that escape the normal process of division and begin their own plan to replicate in the body.

8 Jul 2016

Study finds microRNA let-7 plays key role in restricting neuroblastoma

Great strides have been made in treating neuroblastoma, the most common cancer in infants and toddlers. However, advanced cases are often fatal, and children who survive often face life-long physical and intellectual challenges related to their treatment.

8 Jul 2016

Curza receives SBIR grant to develop new class of broad spectrum antibiotics

Curza Global, LLC, a company based on technology developed at the University of Utah, has been awarded a Phase I Small Business Innovation Research grant of $598,770 entitled "Natural product-inspired antibacterials with unique ribosomal binding" that will provide two years of support.

7 Jul 2016

Activation of D2 neurons may help decrease alcohol consumption, research shows

By activating particular neurons, we may be able to influence alcohol drinking behavior, according to new findings published by researchers at the Texas A&M Health Science Center College of Medicine in the journal Biological Psychiatry.

7 Jul 2016

Minoryx Therapeutics initiates phase 1 clinical trial of MIN-102

Minoryx Therapeutics, a drug development company specialized in the discovery and development of new drugs for orphan diseases, today announces the initiation of its first-in-man Phase 1 clinical trial for its lead compound MIN-102.

7 Jul 2016

Researchers identify potential biomarker for Parkinson's disease in biobanked urine samples

For more than five years, urine and cerebral-spinal fluid samples from patients with Parkinson's disease have been locked in freezers in the NINDS National Repository, stored with the expectation they might someday help unravel the still-hidden course of this slow-acting neurodegenerative disease.

6 Jul 2016

European Commission approves extended indication for Amgen's Kyprolis (carfilzomib) for the treatment of relapsed multiple myeloma patients

Amgen has announced that the European Commission (EC) has approved a variation to the marketing authorization for Kyprolis® (carfilzomib) to include use in combination with dexamethasone alone for adult patients with multiple myeloma who have received at least one prior therapy. The extended indication marks the second approval for Kyprolis by the EC in less than a year.

6 Jul 2016

Therapeutics News and Research

Researchers discover novel neuroprotection strategies to slow progression of Parkinson's disease

New research delves into physical properties of nanoparticles for successful drug delivery

Identifying new pathway of EZH2 gene may lead to targeted therapies for aggressive breast cancer

Scientists develop new way to resurface arthritic hip joint

Low-FODMAP rye bread may reduce symptoms of IBS

Study produces most detailed picture to date of genetics underlying type 2 diabetes

Scientists discover improved method for large scale production of human stem cells

Sugar-binding protein galectin-9 could be new weapon to fight HIV

Antibodies from survivors of filovirus infection may offer protection against other filoviral diseases

New multicomponent reactions to develop active compounds against sleeping sickness

Research findings unveil new avenues to monitor, treat lung cancer more effectively

Aelan's researchers develop novel epigenetic biomarker for diagnosis of AD

Scientists develop new online open-access data tool to improve drug safety

Moffitt researchers discover novel way to control SETDB1 protein upregulated in cancer

Study finds microRNA let-7 plays key role in restricting neuroblastoma

Curza receives SBIR grant to develop new class of broad spectrum antibiotics

Activation of D2 neurons may help decrease alcohol consumption, research shows

Minoryx Therapeutics initiates phase 1 clinical trial of MIN-102

Researchers identify potential biomarker for Parkinson's disease in biobanked urine samples

European Commission approves extended indication for Amgen's Kyprolis (carfilzomib) for the treatment of relapsed multiple myeloma patients

Advancing therapeutic biopolymer development eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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