Clinical Trial News and Research

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New study aims to understand why skin grafts have high rate of rejection

When it comes to transplant rejection, some organs are far trickier than others. Some transplantable organs, such as the liver, are readily accepted by the recipient's immune system, rarely triggering an immune response and rejection

7 Sep 2018

Mayo Clinic physicians win SU2C Catalyst Award to fund melanoma research

Mayo Clinic physicians Matthew Block, M.D., Ph.D. and Tina Hieken, M.D., have received a Stand up to Cancer Catalyst Award to fund melanoma research and a neoadjuvant clinical trial.

7 Sep 2018

Research team identifies new therapeutic target for castration-resistant prostate cancer

A collaborative research team has linked the development of castration-resistant prostate cancer and resistance to treatment to a lack of androgen receptor expression in prostate cancer cells, identifying a new therapeutic target for one of the deadliest forms of cancer among men.

7 Sep 2018

Verastem doses first patient in Phase I/II clinical trial of duvelisib in combination with venetoclax

Verastem, Inc., operating as Verastem Oncology, a biopharmaceutical company focused on developing and commercializing medicines to improve the survival and quality of life of cancer patients, today announced dosing of the first patient in a multicenter Phase I/II clinical trial at the Dana-Farber/Harvard Cancer Center of duvelisib in combination with venetoclax in patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma.

6 Sep 2018

BeiGene collaborates with SpringWorks to evaluate new combinational therapy for solid tumors

BeiGene, Ltd., a commercial-stage biopharmaceutical company focused on developing and commercializing innovative molecularly-targeted and immuno-oncology drugs for the treatment of cancer, and SpringWorks Therapeutics, a clinical-stage rare disease and oncology company focused on sourcing and developing innovative treatments for underserved patient populations, announced today that the companies have entered into a global clinical collaboration agreement to evaluate the safety, tolerability and preliminary efficacy of combining BeiGene's investigational RAF dimer inhibitor, lifirafenib and SpringWorks Therapeutics' investigational MEK inhibitor, PD-0325901, in patients with advanced solid tumors.

6 Sep 2018

Chalmers University professor develops new theory for origin of 'phantom limb pain'

Dr Max Ortiz Catalan of Chalmers University of Technology, Sweden, has developed a new theory for the origin of the mysterious condition, 'phantom limb pain'. Published in the journal Frontiers in Neurology, his hypothesis builds upon his previous work on a revolutionary treatment for the condition, that uses machine learning and augmented reality.

6 Sep 2018

Phase 1 clinical trial examining topical cream plus influenza vaccine is underway

A Phase 1 clinical trial examining whether a topical cream can enhance the immune response conferred by a "pre-pandemic" influenza vaccine is underway at Baylor College of Medicine in Houston.

6 Sep 2018

American Pain Society encouraged by progress toward increased funding for pain research

It's been more than two years since the National Institutes of Health released its National Pain Strategy, a comprehensive population health-level strategy for pain, and a year since announcing its Federal Pain Strategy, a long-term strategic plan for pain research.

6 Sep 2018

Clinical trial to examine whether sleep apnea treatment prevents recurrent stroke, improves recovery

Recovery after a stroke is often challenging, and patients are also at heightened risk of another stroke. Now, with the launch of a new clinical trial, stroke survivors across the country will have the opportunity to help guide how future patients are cared for after a stroke.

5 Sep 2018

Phase 2 clinical study reports best outcomes to date for older Hodgkin lymphoma patients

Recently published results of a phase 2 clinical trial have shown the best outcomes to date for newly diagnosed older Hodgkin lymphoma patients treated with brentuximab vedotin given before and after doxorubicin, vinblastine and dacarbazine chemotherapy, which is the standard of care.

5 Sep 2018

Powerful antioxidant can lower the risk of second heart attack or stroke

Doctors have long known that in the months after a heart attack or stroke, patients are more likely to have another attack or stroke. Now, a paper in the Journal of the American College of Cardiology explains what happens inside blood vessels to increase risk - and suggests a new way to treat it.

5 Sep 2018

Anti-inflammatory use during surgery may lead to improved outcomes for cancer patients

The world's first clinical trial (SURGUVANT) evaluating anti-inflammatory use at the time of surgery in colon cancer patients to improve their cancer outcome has been published in scientific journal, BMC Cancer.

4 Sep 2018

Hormone link between diabetes and hypertension discovered

Physician researchers with The Ohio State University College of Medicine at the Wexner Medical Center say increased levels of the hormone aldosterone, already associated with hypertension, can play a significant role in the development of diabetes, particularly among certain racial groups.

4 Sep 2018

New project aims to combat drug-resistant bacteria in hospitals

Antibiotic resistance is a big global public health problem. Of particular concern are multidrug-resistant Gram-negative bacteria, which are among the leading causes of serious, debilitating and life threatening healthcare-associated infections.

3 Sep 2018

Muscle dystrophy treatment in dogs with Crispr gene editing

Researchers in the United States have shown that genetically caused muscular dystrophy in dogs could be corrected using genetic editing tools. Muscular dystrophy is one of the most common fatal genetic conditions seen in children and is also seen in dogs

31 Aug 2018

Researchers discover potential new approach to block growth of HER2 positive breast cancer

Researchers at Mayo Clinic have identified an important new pathway by which HER2 positive breast cancers grow and have discovered that a dietary supplement called cyclocreatine may block the growth of HER2 positive breast cancer.

30 Aug 2018

Pfizer terminates clinical studies evaluating domagrozumab for treatment of Duchenne muscular dystrophy

Pfizer Inc. announced today that it is terminating two ongoing clinical studies evaluating domagrozumab (PF-06252616) for the treatment of Duchenne muscular dystrophy (DMD): a Phase 2 safety and efficacy study (B5161002) and an open-label extension study (B5161004).

30 Aug 2018

Clinical trial: Promising drug slows brain shrinkage in progressive MS patients

A promising drug slowed brain shrinkage in progressive multiple sclerosis (MS) by nearly half, according to new research led by Cleveland Clinic. Very limited therapies are currently available for this disabling form of the disease.

30 Aug 2018

Component of cannabis could help in psychosis

Researchers from King’s College London have now found how the chemical cannabidiol or CBD from cannabis can reduce the abnormal brain activity in patients who are at risk of psychosis. The study was published in the latest issue of the journal JAMA Psychiatry.

30 Aug 2018

Clinical trial provides 'strong signal' that TAVR is safe for patients with low surgical risk

Results of a clinical trial using transcatheter aortic valve replacement provided a "strong signal" that it is safe for patients with low surgical risk, potentially helping to open the way for broader use of the minimally invasive procedure, also known as TAVR.

30 Aug 2018

Clinical Trial News and Research

New study aims to understand why skin grafts have high rate of rejection

Mayo Clinic physicians win SU2C Catalyst Award to fund melanoma research

Research team identifies new therapeutic target for castration-resistant prostate cancer

Verastem doses first patient in Phase I/II clinical trial of duvelisib in combination with venetoclax

BeiGene collaborates with SpringWorks to evaluate new combinational therapy for solid tumors

Chalmers University professor develops new theory for origin of 'phantom limb pain'

Phase 1 clinical trial examining topical cream plus influenza vaccine is underway

American Pain Society encouraged by progress toward increased funding for pain research

Clinical trial to examine whether sleep apnea treatment prevents recurrent stroke, improves recovery

Phase 2 clinical study reports best outcomes to date for older Hodgkin lymphoma patients

Powerful antioxidant can lower the risk of second heart attack or stroke

Anti-inflammatory use during surgery may lead to improved outcomes for cancer patients

Hormone link between diabetes and hypertension discovered

New project aims to combat drug-resistant bacteria in hospitals

Muscle dystrophy treatment in dogs with Crispr gene editing

Researchers discover potential new approach to block growth of HER2 positive breast cancer

Pfizer terminates clinical studies evaluating domagrozumab for treatment of Duchenne muscular dystrophy

Clinical trial: Promising drug slows brain shrinkage in progressive MS patients

Component of cannabis could help in psychosis

Clinical trial provides 'strong signal' that TAVR is safe for patients with low surgical risk

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