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Alnylam reports new results from investigational RNAi therapeutic programs

Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), the leading RNAi therapeutics company, announced today preliminary results from its ongoing Phase 2 open-label extension (OLE) studies with patisiran and revusiran, both investigational RNAi therapeutics targeting transthyretin (TTR) for the treatment of hereditary TTR-mediated amyloidosis (hATTR amyloidosis).

6 Jul 2016

Deutetrabenazine may help improve chorea symptoms in patients with HD

People with Huntington disease (HD) experienced improvements in chorea while taking deutetrabenazine (SD-809) compared to placebo, according to a paper published today in the Journal of the American Medical Association.

6 Jul 2016

Novel technique could help discover genes linked to complex traits in any animal model

Mice are one of the most commonly used laboratory organisms, widely used to study everything from autism to infectious diseases. Yet genomic studies in mice have lagged behind those in humans.

4 Jul 2016

New AAV 3.0 program to create next-generation viral vectors for better treatment of inherited diseases

The Perelman School of Medicine at the University of Pennsylvania has launched a new program, called AAV 3.0, to create new viral vectors to find quicker and better treatments for an array of diseases. James M. Wilson, MD, PhD, a professor of Medicine and director of the Orphan Disease Center, will lead an interdisciplinary team of over 30 scientists to create this new technology platform with support provided by the University of Pennsylvania Health System.

30 Jun 2016

Researchers reveal novel mechanism by which viral protein VII suppresses immune alarm signals

Viruses must avoid a host's immune system to establish successful infections—and scientists have discovered another tool that viruses use to frustrate host defenses.

30 Jun 2016

Researcher receives federal grant to advance study of tumor nanoimmunology

The five-year grant was awarded by the National Cancer Institute of the National Institutes of Health. The funds come on top of four previous grants to support Ljubimova's work. In all, the institute has awarded Ljubimova $16.5 million over the last five years.

29 Jun 2016

New technology could help deliver treatments for brain injuries

A new study led by scientists at the Sanford Burnham Prebys Medical Discovery Institute describes a technology that could lead to new therapeutics for traumatic brain injuries. The discovery, published today in Nature Communications, provides a means of homing drugs or nanoparticles to injured areas of the brain.

29 Jun 2016

Researchers devise method to identify functional contribution of SIRT6

The enzyme sirtuin 6, or SIRT6, serves many key biological functions in regulating genome stability, DNA repair, metabolism and longevity, but how its multiple enzyme activities relate to its various functions is poorly understood.

29 Jun 2016

Study examines role of HOX genes in ovarian cancer resistance

A new UK study has identified a gene signature that predicts poor survival from ovarian cancer. The study also identified genes which help the cancer develop resistance to chemotherapy - offering a new route to help tackle the disease.

28 Jun 2016

Experimental lipid-lowering drug improves glucose control in diabetic patients

High triglycerides -- a type of fat, or lipid, in the blood -- increase the risk of heart disease and perhaps type 2 diabetes. For the first time, it has been shown that profoundly lowering triglycerides in diabetics improves their insulin sensitivity over time, which helps them maintain healthy glucose - blood sugar -- levels.

28 Jun 2016

Deficiency in NMD could cause inflammatory myofibroblastic tumors

Inflammatory myofibroblastic tumors (IMTs) — masses of immune cells— are benign, but poorly understood. Current IMT treatments often have side effects and surgery is sometimes not an option due to the tumor's proximity to vital organs.

28 Jun 2016

Why does appetite loss occur during illness? An interview with Prof. Conti and Prof. Francesconi

Appetite, as a word, come from the Latin appetitus, meaning "desire for.” Therefore, appetite can be defined as a pleasurable sensation or the desire to eat. This sensation is coordinated by several brain areas associated with reward processing such amygdala, hippocampus, ventral pallidum, nucleus accumbens and striatum, and others.

28 Jun 2016

New computer model shows how spleen filters misshapen red blood cells

Researchers, led by Carnegie Mellon University President Subra Suresh and MIT Principal Research Scientist Ming Dao, have created a new computer model that shows how tiny slits in the spleen prevent old, diseased or misshapen red blood cells from re-entering the bloodstream.

28 Jun 2016

Vice President Biden to host Cancer Moonshot Summit in Washington, D.C.

Vice President Biden and Dr. Jill Biden will host a Cancer Moonshot Summit in Washington, D.C. at the White House. Cheryl Willman, MD, Director and CEO of The University of New Mexico Comprehensive Cancer Center, will attend.

25 Jun 2016

Research finds significant increase in use of chiropractic services among veterans

The use of chiropractic services in the Department of Veterans Affairs health care system has seen a steep rise over more than a decade, according to research published in the Journal of Manipulative and Physiological Therapeutics, the official scientific journal of the American Chiropractic Association.

25 Jun 2016

Researchers tune into previously unknown cross talk between estrogen and progesterone receptors

One of the first clues pathologists look for in tissue from a newly diagnosed breast cancer patient is the estrogen receptor, a nuclear protein that converts hormonal messages in the bloodstream into instructions for the cell about how to behave

24 Jun 2016

Researchers identify new potential target for pancreatic cancer treatment

Using an innovative approach to identify a cancer's genetic vulnerabilities by more swiftly analyzing human tumors transplanted into mice, researchers have identified a new potential target for pancreatic cancer treatment, published online in Cell Reports.

24 Jun 2016

Therapeutics News and Research

Alnylam reports new results from investigational RNAi therapeutic programs

Deutetrabenazine may help improve chorea symptoms in patients with HD

Novel technique could help discover genes linked to complex traits in any animal model

New AAV 3.0 program to create next-generation viral vectors for better treatment of inherited diseases

Researchers reveal novel mechanism by which viral protein VII suppresses immune alarm signals

Researcher receives federal grant to advance study of tumor nanoimmunology

New technology could help deliver treatments for brain injuries

Researchers devise method to identify functional contribution of SIRT6

Study examines role of HOX genes in ovarian cancer resistance

Experimental lipid-lowering drug improves glucose control in diabetic patients

Deficiency in NMD could cause inflammatory myofibroblastic tumors

Why does appetite loss occur during illness? An interview with Prof. Conti and Prof. Francesconi

New computer model shows how spleen filters misshapen red blood cells

Vice President Biden to host Cancer Moonshot Summit in Washington, D.C.

Research finds significant increase in use of chiropractic services among veterans

Researchers tune into previously unknown cross talk between estrogen and progesterone receptors

Researchers identify new potential target for pancreatic cancer treatment

Novel combination therapy slows cancer growth in patients with advanced solid tumors

Marketing authorisation for Penthrox handheld inhaler issued in France

Understanding cancer resistance in mole-rats may help advance human treatment in future

Industry Focus eBook - Microbiome (1st edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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