Therapeutics News and Research

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RVFV uses cancer pathway to hijack host cell and cause infection

Viruses can't live without us -- literally. As obligate parasites, viruses need a host cell to survive and grow. Scientists are exploiting this characteristic by developing therapeutics that close off pathways necessary for viral infection, essentially stopping pathogens in their tracks.

17 Jun 2016

Study sheds new light on how overeating may lead to more eating

Research is finally beginning to shed light on some of the reasons that extra weight is difficult to shed permanently. Now, a new study has uncovered another method by which the gut senses how much food a person eats and relays that to the brain.

16 Jun 2016

New research paves way for potential notch-based anticancer therapeutics

A recent study led by scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, in collaboration with the Univerity of Maryland School of Pharmacy and StemSynergy Therapeutics, Inc., has identified a small-molecule inhibitor of the Notch pathway, paving the way for a potential new class of personalized cancer medicines.

16 Jun 2016

Already-approved drugs can fight apoptosis evasion in cancer

Cancer cells don't die when they're supposed to. Animal and human bodies follow an orderly process of birthing new cells and killing old ones. But cancer cells escape programmed cell death, called apoptosis, and multiply uncontrollably.

15 Jun 2016

Researchers find new method to replicate one of earliest changes in Alzheimer’s disease

Researchers at the Babraham Institute have found a way to replicate one of the earliest changes in Alzheimer's disease in a dish. This means that it should now be possible to find out a lot more about why it happens - and how to stop it. The new findings are published in the journal Molecular Neurodegeneration and supported by the charity Alzheimer's Research UK.

15 Jun 2016

NCMC develops national roadmap for large-scale manufacturing of cell-based therapeutics

An industry-driven consortium has developed a national roadmap designed to chart the path to large-scale manufacturing of cell-based therapeutics for use in a broad range of illnesses including cancer, neuro-degenerative diseases, blood and vision disorders and organ regeneration and repair.

15 Jun 2016

FDG-PET imaging tracks ability of atezolizumab to bolster immunity against NSCLC

Non-small cell lung cancers have a collective reputation for not responding very well to chemotherapy. Researchers at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) are presenting a means of evaluating an immunotherapy that fights off NSCLC by strengthening a patient's own immune system.

14 Jun 2016

Griffith researchers move one step closer to understanding cause of Chronic Fatigue Syndrome

A new finding in the cause of Chronic Fatigue Syndrome has been identified by researchers at Griffith University who say they are getting much closer to a complete understanding of this disabling condition.

13 Jun 2016

Intrinsic subtyping of breast cancer can aid prognosis, treatment of tumor patients

Published in JAMA Oncology, Principal Investigator of Vall d´Hebron Institute of Oncology´s Translational Genomics Group, Team Leader of translational genomics and targeted therapeutics in solid tumors at the August Pi I Sunyer Biomedical Research Institute, and Head of Medical Oncology at the Hospital Clínic in Barcelona, Aleix Prat has led a study showing the intrinsic subtyping of breast cancer by means of a genomic test as the most important prognostic factor in advanced or metastatic hormone-sensitive breast cancer.

10 Jun 2016

Glial cells may play crucial role in addiction-related behaviors

Addiction may be viewed as a disorder of reward learning. To date, addiction research has focused on the molecular adaptations through which memories of exposure to abused substances are encoded and maintained by nerve cells.

9 Jun 2016

Scientists explore effects of physiological fluid shear on dangerous type of Salmonella

Once inside the human body, infectious microbes like Salmonella face a fluid situation. They live in a watery world, surrounded by liquid continually flowing over and abrading their cell surfaces--a property known as fluid shear.

9 Jun 2016

Research reveals complicated love story between bacterial virulence and antibiotic resistance

It's thought that antibiotic resistance is associated with a fitness cost, meaning that bacteria that develop antibiotic resistance must sacrifice something in order to do so. Because of this, proper use of antibiotics should result in susceptible strains eventually replacing resistant ones.

8 Jun 2016

Automated OCL insulin feedback controller improves glucose control in diabetic children, adolescents

Using an automated insulin feedback controller as part of an overnight closed-loop (OCL) control system improved glucose control (increased time within target glucose range) and reduced episodes of nocturnal hypoglycemia in children and adolescents.

8 Jun 2016

Researchers examine pan-genome of deadly Staph bacteria

Staphylococcus aureus bacteria are the leading cause of skin, soft tissue and several other types of infections. Staph is also a global public threat due to the rapid rise of antibiotic-resistant strains, including methicillin-resistant Staphylococcus aureus or MRSA.

7 Jun 2016

HKUST study suggests innate immune response plays vital role in pathogenesis of AD

Alzheimer's disease (AD) is a devastating condition with no known effective treatment. The disease is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment. Emerging evidence suggests that the innate immune response plays a major role in the pathogenesis of AD.

7 Jun 2016

Autoimmune diseases among lung cancer patients may make them unsuitable for immunotherapy

A significant proportion of lung cancer patients also have autoimmune disease, which may make them unsuitable for increasingly popular immunotherapy treatments, a team of researchers at UT Southwestern Medical Center's Harold C. Simmons Comprehensive Cancer Center has found.

6 Jun 2016

MBC Project engages patients directly to accelerate cancer research

A crowd-sourcing strategy aimed at accelerating research into metastatic breast cancer has connected advocacy groups, social media, and a dedicated web site to register more than 2,000 patients from all 50 states in its first seven months, say researchers from Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard.

6 Jun 2016

Analysing blood metabolites may help monitor effects of novel drugs

Testing for metabolic changes in the blood could indicate whether a cancer drug is working as designed, a new study reports.

3 Jun 2016

Shift work alters internal body clock and leads to strokes, serious brain implications

Statistics show that some 15 million Americans don't work the typical nine-to-five. These employees (or shift workers), who punch in for graveyard or rotating shifts, are more prone to numerous health hazards, from heart attacks to obesity, and now, new research, published in Endocrinology, shows shift work may also have serious implications for the brain.

2 Jun 2016

$Sostdc1 gene may play vital role in fracture healing process$

Sostdc1 gene may play vital role in fracture healing process

New identification of a gene involved in the fracture healing process could lead to the development of new therapeutic treatments for difficult-to-heal injuries.

2 Jun 2016

Therapeutics News and Research

RVFV uses cancer pathway to hijack host cell and cause infection

Study sheds new light on how overeating may lead to more eating

New research paves way for potential notch-based anticancer therapeutics

Already-approved drugs can fight apoptosis evasion in cancer

Researchers find new method to replicate one of earliest changes in Alzheimer’s disease

NCMC develops national roadmap for large-scale manufacturing of cell-based therapeutics

FDG-PET imaging tracks ability of atezolizumab to bolster immunity against NSCLC

Griffith researchers move one step closer to understanding cause of Chronic Fatigue Syndrome

Intrinsic subtyping of breast cancer can aid prognosis, treatment of tumor patients

Glial cells may play crucial role in addiction-related behaviors

Scientists explore effects of physiological fluid shear on dangerous type of Salmonella

Research reveals complicated love story between bacterial virulence and antibiotic resistance

Automated OCL insulin feedback controller improves glucose control in diabetic children, adolescents

Researchers examine pan-genome of deadly Staph bacteria

HKUST study suggests innate immune response plays vital role in pathogenesis of AD

Autoimmune diseases among lung cancer patients may make them unsuitable for immunotherapy

MBC Project engages patients directly to accelerate cancer research

Analysing blood metabolites may help monitor effects of novel drugs

Shift work alters internal body clock and leads to strokes, serious brain implications

Sostdc1 gene may play vital role in fracture healing process

Industry Focus eBook - Biotechnology (4th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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