Malignant News and Research

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Optically controlled local heat-pulse method manipulates temperature in cells

A team of researchers led by Osaka University finds that mutant variants of the calcium channel protein RyR1 are hypersensitive to heat, which creates a positive feedback loop of calcium release and leads to malignant hyperthermia

8 Aug 2022

Combination of ultrasound and microbubbles helps medicines pass through the blood-brain barrier

Combining ultrasound and bubbles helps medicines pass through the protective blood-brain barrier and is giving hope for improved treatment of several diseases.

5 Aug 2022

Epigenetic changes prevent iron-associated programmed cell death in leukemia, research shows

The article, published in the journal Redox Biology by the group of Dr. Manel Esteller, shows that epigenetic changes prevent iron-associated programmed cell death in leukemia and show a new target for treatment with experimental drugs.

1 Aug 2022

New glioma drug may represent a paradigm for designing therapeutics exploiting specific DNA repair

A new class of glioma drugs exploits tumors that lack the DNA repair enzyme MGMT; the drugs lead to the generation of cytotoxic DNA and selectively kill tumor cells without the risk of resistance, researchers report.

29 Jul 2022

Analyzing pathological outcomes in single vs multiple architectural distortion on digital breast tomosynthesis

According to ARRS' American Journal of Roentgenology (AJR), for patients with multiple architectural distortion (AD) identified on digital breast tomosynthesis (DBT), biopsy of all areas may be warranted, given the variation of pathologic diagnoses across AD in individual patients.

28 Jul 2022

New 'decoy receptor' molecules inhibit growth of multiple myeloma and diffuse large B cell lymphoma in mice

Researchers at Stanford University have developed "decoy receptor" molecules that inhibit the growth of both multiple myeloma (MM) and diffuse large B cell lymphoma (DLBCL) in mice.

26 Jul 2022

Study suggests a possible treatment approach for cancer and cardiovascular disease

A key molecule for cancer metastasis has been identified as a molecule already known for its involvement in cardiovascular disease, suggesting a possible treatment approach for both diseases simultaneously.

25 Jul 2022

Study clarifies the role of intestinal white blood cells in colorectal cancer

Colorectal tumors are swarming with white blood cells, but whether these cells help or hinder the cancer is hotly debated.

22 Jul 2022

Phase I clinical trial of new blocking antibody therapy shows promising results for the treatment of advanced medulloblastoma

Effective and safe treatments are needed for medulloblastoma - the most common type of cancerous brain tumor in children - especially for patients whose cancer has spread to the spinal cord.

14 Jul 2022

Hitting rewind on the spread of pancreatic cancer

News-Medical speaks to Linxiang Lan, a staff scientist at The Institute of Cancer Research, about a fundamental discovery that could pave way for new pancreatic cancer treatments.

14 Jul 2022

Children born to mothers with PCOS have increased risk of developing childhood illnesses

Children born to mothers with polycystic ovary syndrome (PCOS) have an increased risk of developing infections, allergies and other childhood illnesses by the age of 13, according to the largest study to investigate this.

14 Jul 2022

Researchers develop an AI system to classify IBD neoplasia lesions accurately

The incidence of inflammatory bowel disease (IBD) - an intractable disease characterized by chronic inflammation of the gastrointestinal (GI) tract - has increased significantly in Japan.

13 Jul 2022

Study offers insight into cancer cell migration and opens new possibilities for stopping it

An international research group has investigated the mechanisms of cell migration and the impact of tissue rigidity on cell positioning and steering. The research sheds light on e.g. cancer cell migration and opens new possibilities for stopping and directing it.

12 Jul 2022

Study sheds light on cell type-specific biomarkers of melanoma

A new UC Davis-led study sheds light on cell type-specific biomarkers, or signs, of melanoma. The research was recently published in the Journal of Investigative Dermatology.

10 Jul 2022

Study identifies chromosomal abnormalities associated with relapse in frequent subtype of childhood B-ALL

An international research team coordinated by Dr. Oscar Molina and Dr. Pablo Menéndez, from the Josep Carreras Leukaemia Research Institute, identifies chromosomal abnormalities associated to relapse in a frequent subset of B-cell Acute Lymphoblastic Leukemia (B-ALL), a severe condition affecting especially children.

7 Jul 2022

Scientists unravel the neuronal metabolism in learning and memory

Exploring the predictive properties of neuronal metabolism can contribute to our understanding of how humans learn and remember.

5 Jul 2022

Research uses big data to find cancerous mutations in cells

Artificial intelligence and machine learning are among the latest tools being used by cancer researchers to aid in detection and treatment of the disease.

5 Jul 2022

Researchers fabricate highly-sensitive SERS probes to detect the PD-L1 biomarker

Recently, a team led by Prof. Huang Qing at the Institute of Intelligent Machines, Hefei Institutes of Physical Science (HFIPS) of Chinese Academy of Sciences (CAS) have reported the fabrication of ultrasensitive biosensors based on Surface-enhanced Raman Spectroscopy (SERS) to detect the cancer metastasis related programmed death ligand (PD-L1) biomarker.

1 Jul 2022

New K+-sensitive dual-mode imaging probe for diagnosis of tumor malignancy

Tumor malignancy identification plays an essential role in clinical management of cancer. Currently, biopsy is the gold standard for malignancy identification in most tumor cases, it is, however, invasive that can cause great discomfort to patients, and potentially increase the risk of distant metastases due to the complex sampling process.

1 Jul 2022

Scientists use single cell techniques to uncover a central dichotomy for colorectal cancer cells

A team of clinician-scientists and scientists, led by the National Cancer Centre Singapore and A*STAR's Genome Institute of Singapore together with collaborators in Europe and South Korea, used single-cell techniques to uncover a central dichotomy for colorectal cancer cells, leading to a proposed update of the classification system for the disease.

1 Jul 2022

Malignant News and Research

Optically controlled local heat-pulse method manipulates temperature in cells

Combination of ultrasound and microbubbles helps medicines pass through the blood-brain barrier

Epigenetic changes prevent iron-associated programmed cell death in leukemia, research shows

New glioma drug may represent a paradigm for designing therapeutics exploiting specific DNA repair

Analyzing pathological outcomes in single vs multiple architectural distortion on digital breast tomosynthesis

New 'decoy receptor' molecules inhibit growth of multiple myeloma and diffuse large B cell lymphoma in mice

Study suggests a possible treatment approach for cancer and cardiovascular disease

Study clarifies the role of intestinal white blood cells in colorectal cancer

Phase I clinical trial of new blocking antibody therapy shows promising results for the treatment of advanced medulloblastoma

Hitting rewind on the spread of pancreatic cancer

Children born to mothers with PCOS have increased risk of developing childhood illnesses

Researchers develop an AI system to classify IBD neoplasia lesions accurately

Study offers insight into cancer cell migration and opens new possibilities for stopping it

Study sheds light on cell type-specific biomarkers of melanoma

Study identifies chromosomal abnormalities associated with relapse in frequent subtype of childhood B-ALL

Scientists unravel the neuronal metabolism in learning and memory

Research uses big data to find cancerous mutations in cells

Researchers fabricate highly-sensitive SERS probes to detect the PD-L1 biomarker

New K+-sensitive dual-mode imaging probe for diagnosis of tumor malignancy

Scientists use single cell techniques to uncover a central dichotomy for colorectal cancer cells

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