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SARS-CoV-2 Mpro inhibitors built on rattlesnake venom scaffold

A new study describes the development of new molecules with inhibitory activity against the SARS-CoV-2 viral main protease (Mpro) enzyme, based on rattlesnake venom.

29 Apr 2022

Scientists identify the neural basis of pleasant touch sensation

Studying mice, scientists at Washington University School of Medicine in St. Louis have identified a neural circuit and a neuropeptide - a chemical messenger that carries signals between nerve cells - that transmit the sensation known as pleasant touch from the skin to the brain.

28 Apr 2022

Researchers investigate O-glycosylation in cells infected with Ebola

Researchers from the Copenhagen Center for Glycomics have been investigating O-glycosylation in cells infected with Ebola virus in order to better understand the disease.

28 Apr 2022

Researchers demonstrate the efficiency of T-cell immune response against the Omicron variant

Scholars from HSE University and the RAS Institute of Bioorganic Chemistry have demonstrated the efficiency of T-cell immune response against the Omicron variant of SARS-CoV-2.

28 Apr 2022

Evidence of increased intrinsic cleavability of SARS-CoV-2 Omicron spike protein by host cell furin

Researchers conducted an in vitro analysis to assess the host cell furin-mediated cleavability of the spike protein of the SARS-CoV-2 Omicron (B.1.529) variant.

26 Apr 2022

Nanobody effectively neutralizes pseudotyped ancestral SARS-CoV-2 and Omicron spike proteins

Researchers identified a nanobody inhibiting SARS-CoV-2 variants.

26 Apr 2022

Study suggests BCG vaccination might confer immunity to SARS-CoV-2

In a recent study posted to the bioRxiv* preprint server, the researchers investigated the impact of Bacillus Calmette-Guérin (BCG) vaccine-induced antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein.

25 Apr 2022

How does SARS-CoV-2 infection affect the diversity of the gut microbiome?

Researchers have been investigating differences in the fungal gut microbiome in patients with mild-to-severe coronavirus disease 2019.

22 Apr 2022

Acquiring real-time, accurate and reproducible 4D bioinformatics data with PaSER

In this interview, Chris Adams Ph.D., Business Development Director, Global Bioinformatics, Life Science Mass Spectrometry at Bruker Daltonics, Billerica, MA, USA talks to News-Medical Life Sciences about acquiring real-time, accurate and reproducible 4D-proteomics data with PaSER.

From Bruker Daltonics 20 Apr 2022

Study demonstrates subset of vaccine-induced HLA-A*24:02-restricted T cells exhibits enhanced reactivity against the Omicron BA.1 variant

Researchers characterized vaccine-induced T cell response specific for spike proteins of several SARS-CoV-2 variants.

20 Apr 2022

Study investigates the production of a virosome-based COVID-19 vaccine candidate

In a new study, different signal peptides, baculovirus transfer vectors, cell lines, infection techniques, and formulation buffers were investigated with the purpose of building a scalable bioprocess to generate high-quality S protein for incorporation in a virosome-based COVID-19 vaccine candidate.

18 Apr 2022

Monoclonal antibodies from COVID-19 convalescent donors target conserved site

Researchers found six monoclonal antibodies binding to the spike proteins of all human coronaviruses.

18 Apr 2022

SARS-CoV-2 RBD is a selective integrin agonist

Researchers assess the Arg-Gly-Asp (RGD) motif-mediated binding of the SARS-CoV-2 RBD and integrin receptors.

18 Apr 2022

Novel transdermal vaccine delivery for COVID-19 and cancer

Researchers assess the efficacy of a fluorocarbon modified chitosan system for the development of SARS-CoV-2 vaccines and tumor immunotherapy.

13 Apr 2022

Researchers find novel inhibitors that may suppress oncogenesis of metastatic prostate cancer

Researchers have found that treating prostate cancer cells with novel cyclin-dependent kinase 19 (CDK19) and homologous cyclin-dependent kinase 8 (CDK8) inhibitors reduces their potential to migrate into and invade surrounding structures.

13 Apr 2022

Venomtech announces new drug development collaboration with Charles River

Venomtech is collaborating with Charles River Laboratories, International Inc. to help drug developers explore venom-derived compounds for a wide range of therapeutic targets.

12 Apr 2022

SARS-CoV-2 mutations change proteasome processing to alter CD8+ T cell responses

Researchers identified mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleoproteins (NP) epitope flanking regions and their potential effects on CD8+ T cell activation.

12 Apr 2022

Nanocell COVID-19 vaccine elicits potent neutralizing response

A new study describes the high level of neutralizing antibodies elicited by a nanocell vaccine against SARS-CoV-2 in vitro, in vivo, and human studies.

11 Apr 2022

Study defines nonredundant role for T cell-derived interleukin-22 in antibacterial defense of colonic crypts

Intestinal epithelial cells line the inner wall of the gut, creating a barrier to dangerous bacteria like enteropathogenic E. coli that seek to attach and efface that barrier, causing diarrhea.

8 Apr 2022

SARS-CoV-2 Omicron variant spike-specific unique cluster of differentiation cells

A new study presented a safe and efficient multi-epitope SARS-CoV-2 vaccine construct against SARS-CoV-2 variants, including Omicron.

8 Apr 2022

Peptides News and Research

SARS-CoV-2 Mpro inhibitors built on rattlesnake venom scaffold

Scientists identify the neural basis of pleasant touch sensation

Researchers investigate O-glycosylation in cells infected with Ebola

Researchers demonstrate the efficiency of T-cell immune response against the Omicron variant

Evidence of increased intrinsic cleavability of SARS-CoV-2 Omicron spike protein by host cell furin

Nanobody effectively neutralizes pseudotyped ancestral SARS-CoV-2 and Omicron spike proteins

Study suggests BCG vaccination might confer immunity to SARS-CoV-2

How does SARS-CoV-2 infection affect the diversity of the gut microbiome?

Acquiring real-time, accurate and reproducible 4D bioinformatics data with PaSER

Study demonstrates subset of vaccine-induced HLA-A*24:02-restricted T cells exhibits enhanced reactivity against the Omicron BA.1 variant

Study investigates the production of a virosome-based COVID-19 vaccine candidate

Monoclonal antibodies from COVID-19 convalescent donors target conserved site

SARS-CoV-2 RBD is a selective integrin agonist

Novel transdermal vaccine delivery for COVID-19 and cancer

Researchers find novel inhibitors that may suppress oncogenesis of metastatic prostate cancer

Venomtech announces new drug development collaboration with Charles River

SARS-CoV-2 mutations change proteasome processing to alter CD8+ T cell responses

Nanocell COVID-19 vaccine elicits potent neutralizing response

Study defines nonredundant role for T cell-derived interleukin-22 in antibacterial defense of colonic crypts

SARS-CoV-2 Omicron variant spike-specific unique cluster of differentiation cells

Editorial Focus eBook - Peptides and Oligonucleotides (2nd edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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