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Common IBD drugs not linked to increased risk of serious infections in children

In a new register-based study, Swedish and Danish researchers show that common drugs for Inflammatory Bowel Disease, so-called TNF-α inhibitors, are not linked to increased risk of serious infections in children. Previous studies have shown an increased risk in corresponding adult patients.

5 Sep 2019

Combination therapy for rheumatoid arthritis may lead to higher remission rates

Researchers at the University of North Carolina Chapel Hill and RTI International, a nonprofit research institute, recently found that patients with early rheumatoid arthritis (RA) may see less disease activity and higher remission rates after biologic therapy plus methotrexate (MTX) rather than either treatment alone.

22 Aug 2019

Study uncovers potential new treatment approach for lung cancer

Lung cancer is the second most common cancer found in both men and women. It is estimated there will be roughly 228,000 new lung cancer cases this year, and nearly 30% of those patients will have mutations in the KRAS pathway.

19 Aug 2019

Researchers identify genes linked to death from sepsis in mice

Sepsis is a life-threatening condition that occurs when the body's immune response to infection spirals out of control.

23 Jul 2019

Using popular anticonvulsant drug to thwart inflammation

Serious conditions, including sepsis, stem from inflammation in the body, and there is a lack of effective medication for sepsis.

2 Jul 2019

Women's pre-pregnancy obesity changes breast milk contents which can affect infant growth

In the first study of its kind, LSU Health New Orleans researchers report that women's pre-pregnancy overweight or obesity produces changes in breast milk, which can affect infant growth.

14 Jun 2019

Research suggests new way to improve the efficacy of arthritis drug

Attaching a removable lock to an arthritis drug can make it safer and more effective, according to a new study publishing June 13 in the open-access journal PLOS Biology led by Wen-Wei Lin of Kaohsiung Medical University, Taiwan.

From PLOS ONE 14 Jun 2019

Researchers uncover new mechanism by which cells communicate in inflammatory processes

A research group from MedUni Vienna and CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences has discovered a new mechanism by which cells communicate in inflammatory processes.

14 Jun 2019

Pre-pregnancy maternal obesity may affect growth of breastfeeding infants

A pioneering new study suggests that babies born to obese or overweight women fail to grow properly during breastfeeding.

14 Jun 2019

Sofrito cooking technique releases healthy nutrients

Researchers have come up with a new study that reveals that cooking vegetables in the sofrito (sauté) with extra virgin olive oil could release certain bioactive compounds from the garlic, onion and tomatoes that could be beneficial for the body.

13 Jun 2019

New computational framework reveals impact of arthritis drugs on gene expression

A new computational framework has revealed key differences between four rheumatoid arthritis medications and their impact on biological pathways in mice.

10 May 2019

HSS researchers provide better understanding of the cellular mechanisms driving rheumatoid arthritis

Newly identified subsets of cell types present in joint tissue in people with rheumatoid arthritis and how they interact may explain why only some people respond to existing medications, according to two studies by co-senior author Laura Donlin, PhD, Co-Director of the Derfner Foundation Precision Medicine Laboratory at Hospital for Special Surgery and collaborating colleagues.

10 May 2019

Researchers identify circulating proteins associated with progression of diabetic kidney disease

In a breakthrough study published today in Nature Medicine, researchers at Joslin Diabetes Center have identified a group of 17 circulating inflammatory proteins that are consistently associated with the development and progression of diabetic kidney disease.

23 Apr 2019

Japanese researchers explain how inflammation causes gastric tumors

In 1982, researchers reported a link between chronic gastritis and stomach bacterium Helicobacter pylori, triggering a flurry of research into this newly-identified pathogen.

16 Apr 2019

Study relates DNA methylation levels to obesity

DNA methylation is a mechanism that regulates whether genes are "on" or "off" and is influenced by hereditary and environmental factors, as well as lifestyle and nutritional habits.

10 Apr 2019

FDA approves treatment for adults with non-radiographic axial spondyloarthritis

The U.S. Food and Drug Administration today approved Cimzia (certolizumab pegol) injection for treatment of adults with a certain type of inflammatory arthritis called non-radiographic axial spondyloarthritis (nr-axSpA), with objective signs of inflammation. This is the first time that the FDA has approved a treatment for nr-axSpA.

28 Mar 2019

Synthetic peptide appears to disrupt inflammation and protect kidneys from nephritis

A synthetic peptide appears to directly disrupt the destructive inflammation that occurs in nephritis, enabling the kidneys to better recover and maintain their important functions, investigators report.

25 Mar 2019

Combined immunosuppression may be effective, safe in treating older patients with Crohn’s disease

Combining medications that suppress the immune system has been successful in treating young patients with Crohn's disease, but some physicians have been reluctant to use this strategy in older patients because of concerns about safety.

20 Mar 2019

Therapeutic endoscopy has an expanding role in the treatment of IBD

According to a new statement from a panel of national and international experts in gastroenterology, inflammatory bowel disease (IBD) and other areas, interventional (or therapeutic) IBD endoscopy has an expanding role in the treatment of disease and of adverse events from surgery.

15 Feb 2019

Study reveals potential pathway for endothelial cells to avoid apoptosis

Cell death is an important aspect of tissue homeostasis, as well as inflammation and disease pathogenesis related to infection, injury, and tumor growth.

17 Jan 2019

Tumor Necrosis Factor News and Research

Common IBD drugs not linked to increased risk of serious infections in children

Combination therapy for rheumatoid arthritis may lead to higher remission rates

Study uncovers potential new treatment approach for lung cancer

Researchers identify genes linked to death from sepsis in mice

Using popular anticonvulsant drug to thwart inflammation

Women's pre-pregnancy obesity changes breast milk contents which can affect infant growth

Research suggests new way to improve the efficacy of arthritis drug

Researchers uncover new mechanism by which cells communicate in inflammatory processes

Pre-pregnancy maternal obesity may affect growth of breastfeeding infants

Sofrito cooking technique releases healthy nutrients

New computational framework reveals impact of arthritis drugs on gene expression

HSS researchers provide better understanding of the cellular mechanisms driving rheumatoid arthritis

Researchers identify circulating proteins associated with progression of diabetic kidney disease

Japanese researchers explain how inflammation causes gastric tumors

Study relates DNA methylation levels to obesity

FDA approves treatment for adults with non-radiographic axial spondyloarthritis

Synthetic peptide appears to disrupt inflammation and protect kidneys from nephritis

Combined immunosuppression may be effective, safe in treating older patients with Crohn’s disease

Therapeutic endoscopy has an expanding role in the treatment of IBD

Study reveals potential pathway for endothelial cells to avoid apoptosis

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