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Tumors commandeer cell death pathway to avoid immune system attack after radiation

Cancer cells avoid an immune system attack after radiation by commandeering a cell signaling pathway that helps dying cells avoid triggering an immune response, a new study led by UTSW scientists suggests.

13 Apr 2020

Molecular pathway responsible for TNBC's progression and spread identified

Immunotherapies have revolutionized treatment for people with a variety of cancers. But when given to those with triple-negative breast cancer, a particularly aggressive form of the disease, less than 20% respond.

13 Apr 2020

FDA approves first-ever treatment for patients with inoperable plexiform neurofibromas

The U.S. Food and Drug Administration has approved Koselugo (selumetinib) for use in patients with inoperable plexiform neurofibromas, a common manifestation in the disease neurofibromatosis type one (NF1).

13 Apr 2020

Researchers reveal novel player in obesity-related breast cancer

It is widely accepted that higher levels of body fat increase the risk of developing breast cancer, as well as other cancers.

13 Apr 2020

PARP inhibitor drugs can be structurally modified to better kill tumor cells

A prospective "PARP inhibitor" drug that has struggled to show effectiveness in clinical trials against cancers can be structurally modified to greatly increase its power to kill tumor cells, researchers from Penn Medicine report this week in Science.

12 Apr 2020

Where cancers spread can give specific insights on disease traits

Kidney cancers that metastasize to the pancreas have a fundamentally different biology from those that metastasize elsewhere, with characteristics that can influence successful treatment, a study led by investigators with the UT Southwestern Kidney Cancer Program suggests.

12 Apr 2020

Mathematical model can predict patient outcomes to adaptive prostate cancer therapy

Prostate cancer is the most common malignancy among men in the United States. It is also the second most common cause of cancer-related deaths. Despite improved treatments for prostate cancer, many patients with advanced disease eventually develop drug resistance.

9 Apr 2020

Missing BAP1 gene renders immunotherapies ineffectual in uveal melanomas

New study from researchers in Finland and the United Kingdom reveals that tumors lacking a protein called BAP1 have an ineffective immune reaction against cancer, thus rendering immunotherapies ineffectual, particularly in uveal melanomas.

9 Apr 2020

'Off-the-shelf' artificial cardiac patch improves heart attack recovery in rat and pig models

Researchers from North Carolina State University have developed an "off-the-shelf" artificial cardiac patch that can deliver cardiac cell-derived healing factors directly to the site of heart attack injury. In a rat model of heart attack, the freezable, cell-free patch improved recovery.

8 Apr 2020

Cancer-causing mutation also promotes inflammation

Analyses of cell signals provide insight into the origin of severe inflammatory symptoms that appear in various types of blood cancer and point to possible therapeutic approaches: In around one-fourth of patients suffering from juvenile myelomonocytic leukemia, there is evidence of mutations in the so-called KRAS gene in the leukemia cells.

8 Apr 2020

Research suggests potential treatment target to slow lymphoma tumor growth

Researchers at the MDC observe the very early stages of blood vessel development in lymph node tumors.

7 Apr 2020

Purdue scientists aim to use protein power to halt tumor growth

In 2018, approximately 324,000 men died from cancer in the United States. The combination of lung cancer, prostate cancer and colorectal cancer equated to half of those deaths.

7 Apr 2020

Personalized biohybrid microswimmers for therapeutic cargo delivery

Tiny biohybrid robots on the micrometer scale can swim through the body and deliver drugs to tumors or provide other cargo-carrying functions. The natural environmental sensing tendencies of bacteria mean they can navigate toward certain chemicals or be remotely controlled using magnetic or sound signals.

7 Apr 2020

Cancer patients face treatment delays and uncertainty as coronavirus cripples hospitals

The federal government has encouraged health centers to delay nonessential surgeries while weighing the severity of patients' conditions and the availability of personal protective equipment, beds and staffing at hospitals.

7 Apr 2020

Researchers develop a unique radiochemical synthesis approach for treating cancer

Radiolabeled molecules, so-called radiotracers, help nuclear physicians to detect and precisely target tumors, which are often developing due to pathological changes in metabolic processes.

7 Apr 2020

Natural approaches along with current therapies could improve colon cancer treatment

Using a modified natural substance along with current approaches could improve colon cancer treatment, according to findings by University of California, Irvine biologists.

6 Apr 2020

Bioengineers combine standard microscopy, infrared light, and AI to assemble digital biopsies

NIBIB-funded bioengineers at the University of Illinois have combined standard microscopy, infrared light, and artificial intelligence to assemble digital biopsies that identify important molecular characteristics of cancer biopsy samples without dyes or labels.

5 Apr 2020

Tumor News and Research

Tumors commandeer cell death pathway to avoid immune system attack after radiation

Molecular pathway responsible for TNBC's progression and spread identified

FDA approves first-ever treatment for patients with inoperable plexiform neurofibromas

Researchers reveal novel player in obesity-related breast cancer

PARP inhibitor drugs can be structurally modified to better kill tumor cells

Where cancers spread can give specific insights on disease traits

Mathematical model can predict patient outcomes to adaptive prostate cancer therapy

Missing BAP1 gene renders immunotherapies ineffectual in uveal melanomas

'Off-the-shelf' artificial cardiac patch improves heart attack recovery in rat and pig models

Cancer-causing mutation also promotes inflammation

Research suggests potential treatment target to slow lymphoma tumor growth

Purdue scientists aim to use protein power to halt tumor growth

Personalized biohybrid microswimmers for therapeutic cargo delivery

Cancer patients face treatment delays and uncertainty as coronavirus cripples hospitals

Researchers develop a unique radiochemical synthesis approach for treating cancer

Natural approaches along with current therapies could improve colon cancer treatment

Bioengineers combine standard microscopy, infrared light, and AI to assemble digital biopsies

Researchers find direct link between MCL1 protein and cell-cycle checkpoint protein

New molecular mechanism that regulates the sentinel cells of the immune system

Starving pancreatic cancer cells of cysteine may induce tumor ferroptosis

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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