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Researchers uncover new way that some bacteria survive when under siege by antibiotics

Researchers have uncovered a new way that some bacteria survive when under siege by antibiotics.

4 Jan 2013

Optofluidics allow for new understanding of resistance to antibiotics

It's often difficult to completely eliminate a bacterial infection with antibiotics; part of the population usually manages to survive. We've known about this phenomenon for quite some time, dating back nearly to the discovery of penicillin. For more than 50 years, scientists have believed that the resistant bacteria were individuals that had stopped growing and dividing.

4 Jan 2013

New technique can precisely add or delete genes in living cells

Researchers at MIT, the Broad Institute and Rockefeller University have developed a new technique for precisely altering the genomes of living cells by adding or deleting genes.

4 Jan 2013

Paratek receives FDA QIDP designation for omadacycline to treat ABSSSI, CABP

Paratek Pharmaceuticals, Inc. today announced that the U.S. Food and Drug Administration (FDA) has designated the Company's lead antibiotic candidate, omadacycline (formerly known as PTK 0796), as a Qualified Infectious Disease Product (QIDP) for both intravenous (IV) and oral formulations in the treatment of acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP).

3 Jan 2013

Gut bacterial communities play an integral role in protecting against human intestinal disorders

Instability in the composition of gut bacterial communities (dysbiosis) has been linked to common human intestinal disorders, including inflammatory bowel disease and colorectal cancer; however, it is unclear if dysbiosis can instigate disease or if it is a consequence of the underlying disorder.

3 Jan 2013

Study identifies mechanism by which bacterium S. aureus colonizes nasal passages

A collaboration between researchers at the School of Biochemistry and Immunology and the Department of Microbiology at Trinity College Dublin has identified a mechanism by which the bacterium Staphylococcus aureus (S. aureus) colonizes our nasal passages. The study, published today in the Open Access journal PLOS Pathogens, shows for the first time that a protein located on the bacterial surface called clumping factor B (ClfB) has high affinity for the skin protein loricrin.

29 Dec 2012

Common cholesterol-lowering drug may help protect against cerebral malaria

Researchers have discovered that adding lovastatin, a widely used cholesterol-lowering drug, to traditional antimalarial treatment decreases neuroinflammation and protects against cognitive impairment in a mouse model of cerebral malaria.

29 Dec 2012

Immune response more complicated than thought

Researchers have found that the orientation and concentration of antibodies could determine the control of bacterial infection.

28 Dec 2012

FDA clears Cepheid Xpert CT/NG molecular diagnostic test

Cepheid today announced that it has received clearance from the U.S. Food & Drug Administration to market Xpert CT/NG. Running on Cepheid's GeneXpert Systems, Xpert CT/NG is a qualitative in vitro molecular diagnostic test for the detection and differentiation of Chlamydia trachomatis and Neisseria gonorrhoeae. For the first time, same-day patient consultation and treatment is possible for the two most common sexually transmitted bacterial infections in the United States.

28 Dec 2012

Researchers study response of living cells to artificial protein

One approach to understanding components in living organisms is to attempt to create them artificially, using principles of chemistry, engineering and genetics. A suite of powerful techniques-collectively referred to as synthetic biology-have been used to produce self-replicating molecules, artificial pathways in living systems and organisms bearing synthetic genomes.

28 Dec 2012

Whole Genome Mapping and NGS deliver high-quality reference genome of domestic goat

OpGen, Inc. today announced its ARGUS Whole Genome Mapping System technology was used in combination with next-generation sequencing (NGS) to produce the first, high-quality reference genome of the domestic goat.

26 Dec 2012

Reviewing G-FINDER report findings

Nick Chapman, a policy analyst at Policy Cures, writes in a guest post on the Global Health Technologies Coalition's "Breakthroughs" blog about "the results of the latest G-FINDER survey on global funding of [research and development (R&D)] for neglected diseases."

21 Dec 2012

Novel testing reaction based on magnetic resonance data

In their quest for new agents, pharmaceutical researchers test millions of substances all over the world. They like using color-forming reactions to identify new molecules. However, in intensively colored solutions or in the case of mixtures with multiple substances these tests fail.

21 Dec 2012

Pergamum’s DPK-060 Phase II trial on acute external otitis meets primary end-point

Pergamum AB announced today that the primary end-point was met in the randomized Phase II trial of DPK-060 for treatment of acute external otitis.

21 Dec 2012

Ebselen effectively inhibits thioredoxin reductase system in H. pylori, M. tuberculosis

A drug currently being used to treat ischemic strokes may prove to be a significant advance in the treatment of tuberculosis and ulcers. In a new research report appearing online in The FASEB Journal, a compound called ebselen effectively inhibits the thioredoxin reductase system in a wide variety of bacteria, including Helicobacter pylori which causes gastric ulcers and Mycobacterium tuberculosis which causes tuberculosis.

21 Dec 2012

Proteins detected in urine may enable diagnosis of Kawasaki disease

A set of proteins detected in urine by researchers at Boston Children's Hospital may prove to be the first biomarkers for Kawasaki disease, an uncommon but increasingly prevalent disease which causes inflammation of blood vessels that can lead to enlarged coronary arteries and even heart attacks in some children.

20 Dec 2012

Antibiotic amoxicillin ineffective for treating cough according to European trial

The antibiotic amoxicillin, that doctors typically prescribe for common lower respiratory tract infections (LRTI) such as cough and bronchitis, is no more effective at relieving symptoms than the use of no medication, even in older patients. The findings from the largest randomised placebo controlled trial of antibiotics for acute uncomplicated LRTI to date are published Online First in The Lancet Infectious Diseases.

20 Dec 2012

V-chip could allow health care providers to do 50 different tests in one go

A new device about the size of a business card could allow health care providers to test for insulin and other blood proteins, cholesterol, and even signs of viral or bacterial infection all at the same time—with one drop of blood. Preliminary tests of the V-chip, created by scientists at The Methodist Hospital Research Institute and MD Anderson Cancer Center, were published last night by Nature Communications.

20 Dec 2012

GI bacteria exert some control over their hosts' appetites: Review

Over the last half decade, it has become increasingly clear that the normal gastrointestinal (GI) bacteria play a variety of very important roles in the biology of human and animals. Now Vic Norris of the University of Rouen, France, and coauthors propose yet another role for GI bacteria: that they exert some control over their hosts' appetites.

20 Dec 2012

Probiotic supplements can benefit body during and after antibiotic use

Recent data suggests that the average American is bombarded with up to 5,000 varying media messages on a daily basis, which can make it tricky to discern fact from fiction. When it comes to your health, there should be absolutely no doubt that the products you select are effectively working to produce the desired results. This is especially true when it comes to the use of probiotics with antibiotics, because some forms are less effective when combined with antibiotics.

19 Dec 2012

Bacterial News and Research

Researchers uncover new way that some bacteria survive when under siege by antibiotics

Optofluidics allow for new understanding of resistance to antibiotics

New technique can precisely add or delete genes in living cells

Paratek receives FDA QIDP designation for omadacycline to treat ABSSSI, CABP

Gut bacterial communities play an integral role in protecting against human intestinal disorders

Study identifies mechanism by which bacterium S. aureus colonizes nasal passages

Common cholesterol-lowering drug may help protect against cerebral malaria

Immune response more complicated than thought

FDA clears Cepheid Xpert CT/NG molecular diagnostic test

Researchers study response of living cells to artificial protein

Whole Genome Mapping and NGS deliver high-quality reference genome of domestic goat

Reviewing G-FINDER report findings

Novel testing reaction based on magnetic resonance data

Pergamum’s DPK-060 Phase II trial on acute external otitis meets primary end-point

Ebselen effectively inhibits thioredoxin reductase system in H. pylori, M. tuberculosis

Proteins detected in urine may enable diagnosis of Kawasaki disease

Antibiotic amoxicillin ineffective for treating cough according to European trial

V-chip could allow health care providers to do 50 different tests in one go

GI bacteria exert some control over their hosts' appetites: Review

Probiotic supplements can benefit body during and after antibiotic use

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