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Blocking stress-responsive protein reduces loss of tumor suppressor gene in breast cancer

Over half of all breast cancers carry genetic defects in the p53 gene, a powerful tumor suppressor. Loss of this gene increases the risk of getting breast cancer and the resultant cancers become highly resistant to treatment.

4 Oct 2018

New approach helps identify molecular alterations linked to prognosis, resistance of cancer

A new computational approach that allows the identification of molecular alterations associated with prognosis and resistance to therapy of different types of cancer was developed by the research group led by Nuno Barbosa Morais, Group Leader at Instituto de Medicina Molecular João Lobo Antunes, and now published open access in Nucleic Acids Research.

4 Oct 2018

DNA Script successfully synthesizes world's first 150-nucleotide strand of DNA

DNA Script, the global leader in the development of enzymatic DNA synthesis, today announced that it has successfully synthesized the world's first 150-nucleotide strand of DNA by de novo enzymatic synthesis.

3 Oct 2018

Researchers insert just enough human DNA into mice to study preterm birth

Preterm birth remains a global epidemic linked to a lifetime of potential health complications. It also is difficult to study in living creatures--especially the uniquely precise biology of preterm birth in humans.

3 Oct 2018

Study sheds light on transport of enzyme involved in stem cell differentiation to DNA

Researchers at the Centre for Genomic Regulation in Barcelona, Spain, have identified the mechanism by which an important enzyme involved in the differentiation of stem cells is brought to the DNA.

3 Oct 2018

Study highlights need for population-specific precision medicine programs in Latin America

Drug safety and effectiveness vary greatly among populations worldwide. Genetics is one of the factors that contribute to variability in drug response.

3 Oct 2018

New, more efficient method for generating brain stem cells in the lab

In two newly published papers, a scientific team at Case Western Reserve University School of Medicine reports on the discovery and implementation of a new, more efficient method for generating an important brain stem cell in the laboratory.

1 Oct 2018

Genetic variants reveal novel therapeutic targets for chronic kidney disease

The kidney does more than double or even triple duty compared to other organs - it extracts waste, balances body fluids, forms urine, regulates blood pressure, and secretes hormones.

1 Oct 2018

TEAD1 protein appears to be important regulator of tumor migration in glioblastoma

A specific protein called TEAD1 is an important regulator of tumor migration in glioblastoma, the most common brain tumor in adults, and deactivating this protein may stop tumor cells from migrating away from the main tumor mass, according to research conducted at the Icahn School of Medicine at Mount Sinai and published October 1 in the journal Nature Communications.

1 Oct 2018

BHCGC consortium to play key role in NIH's large-scale effort to advance precision medicine

The Baylor College of Medicine Human Genome Sequencing Center today announced participation in the National Institutes of Health All of Us Research Program, a large-scale effort to advance precision medicine.

27 Sep 2018

New approach promises to forecast cultivar resistance at much earlier stage

Bacterial wilt devastates food crops all over the world. It destroys major crop plants such as tomatoes, potatoes, bananas, ginger and pepper. It occurs in many countries and attacks over 200 plant species.

27 Sep 2018

Mapping the trillion cells in the human body

The human body is made up of 100 trillion cells and a team of scientists are now planning on cataloguing and imaging each of these cells in the body and creating a 3D human body map.

26 Sep 2018

Researchers to build 3D map of human cells and tissues

Researchers at CMU are working with the NIH to build 3D map of human cells and tissues as part of the Human BioMolecular Atlas Program (HuBMAP).

26 Sep 2018

NIH-funded genome centers to speed up breakthroughs in precision medicine

The All of Us Research Program awarded funds totaling $28.6 million to establish three genome centers around the country. These centers will begin to generate genomic data from biosamples contributed by the program's participants.

26 Sep 2018

Cancer Research UK, Keystone Symposia collaborate for cancer-related research

Keystone Symposia and Cancer Research UK are pleased to announce their new collaboration consisting of a series of annual cancer-related scientific research conferences organized by Keystone Symposia in collaboration with Cancer Research UK.

26 Sep 2018

Driver gene mutations found to be common for cancer metastases

Driver genes in different metastases from the same patient are remarkably similar, providing optimism for the success of future targeted therapies, according to a published study by Science.

25 Sep 2018

Researchers now confirm that genome duplication drives evolution of species

Many wild and cultivated plants arise through the combination of two different species. The genome of these so-called polyploid species often consists of a quadruple set of chromosomes - a double set for each parental species - and thus has about twice as many genes as the original species.

25 Sep 2018

Environmentally-induced gene activity influences IQ test performance

Is there a link between differences in IQ test performance and the activity of certain genes? Researchers from Charité - Universitätsmedizin Berlin have shown that modifications in the structure of a specific gene have a negative impact on individual test performance.

25 Sep 2018

Gene therapy approach could help treat mitochondrial diseases

Researchers have developed a genome-editing tool for the potential treatment of mitochondrial diseases: serious and often fatal conditions which affect 1 in 5,000 people.

24 Sep 2018

New study finds height as possible risk factor for developing varicose veins

The taller you are, the more likely you are to develop varicose veins, according to a study led by Stanford University School of Medicine researchers that examined the genes of more than 400,000 people in search of clues to what causes this common but little understood condition.

24 Sep 2018