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Asthma patients can benefit from type 2 diabetes medication

Type 2 diabetes patients who also have asthma are benefitting from a diabetes medication, typically given to help the pancreas produce more insulin, that also improves asthma symptoms and may reduce lung and airway inflammation.

21 May 2021

Dupilumab considerably reduced asthma exacerbations in young children, shows VOYAGE trial

Results from the VOYAGE study of dupilumab (Dupixent) showed that the monoclonal antibody significantly reduced exacerbations in children ages 6-11 with uncontrolled moderate-to-severe asthma, compared to placebo, according to research presented at the ATS 2021 International Conference. VOYAGE (NCT02948959) is a recently completed randomized, placebo-controlled double-blind multicenter phase 3 clinical trial, that took place in a number of countries.

20 May 2021

Phase 3 trial: New biologic therapy improves outcomes in adults, adolescents with severe asthma

Results from the NAVIGATOR study of tezepelumab showed that the new biologic therapy significantly reduced exacerbations requiring hospital stays and emergency department (ED) visits for adults and adolescents with severe, uncontrolled asthma, according to research presented at the ATS 2021 International Conference.

20 May 2021

Are COVID-19-related complications in children explained by abnormal immune responses?

A common theme in reports on COVID-19 around the world has been the large number of children who have not been infected or shown signs of disease. However, though the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes less acute infection in this age group, it is associated with a severe immune-mediated multisystemic illness called multisystem inflammatory syndrome in children (MIS-C).

20 May 2021

Triple-drug therapy can reduce asthma exacerbations, improve control without major adverse events

Researchers have found that the inclusion of a third drug to commonly used dual-drug inhalers can reduce asthma exacerbations and improve control over the disease in children, adolescents, and adults with moderate-to-severe asthma.

20 May 2021

Four months of multi-drug therapy for tuberculosis is as effective as standard regimen

Four months of multi-drug therapy that included rifapentine and moxifloxacin treated active tuberculosis (TB) as effectively as the standard six-month regimen in a multinational study, cutting treatment time by a third.

20 May 2021

Study shows DHA can reduce early preterm births

In the study published in the journal EClinical Medicine, a dose of 1000 mg of DHA may reduce early preterm births significantly compared to 200 mg as found in some prenatal supplements.

20 May 2021

Antithrombotic endothelial dysfunction is prevented by Tie2 activation in severe COVID-19

Researchers from the US recently assessed if severe COVID-19 is linked to procoagulant dysfunction of the endothelium and changes in the Tie2-angiopoietin axis. They assessed circulating endothelial markers in a study cohort of 98 patients with mild, moderate, or severe COVID-19. This study is published on the medRxiv* preprint server.

19 May 2021

Potential immunotherapy may improve cognitive and behavioral functions after stroke

Specialized immune cells that accumulate in the brain in the days and weeks after a stroke promote neural functions in mice, pointing to a potential immunotherapy that may boost recovery after the acute injury is over, University of Pittsburgh School of Medicine neurologists found.

19 May 2021

Secondhand smoke during pregnancy linked to epigenetic changes in babies

Nearly a quarter of pregnant women say they've been around secondhand smoke - in their homes, at work, around a friend or relative - which, according to new research.

19 May 2021

Toll-like receptor 2 (TLR2) detects the SARS-CoV-2 envelope protein and generates inflammatory cytokines

Researchers at St Jude Children’s Research Hospital found that toll-like receptor 2 detects the SARS-CoV-2 envelope protein-producing inflammatory cytokines.

19 May 2021

Researchers propose new way to treat chronic lung condition

Traditionally, an infection is thought to happen when microbes - bacteria, fungi, or viruses - enter and multiply in the body, and its severity is associated with how prevalent the microbes are in the body.

19 May 2021

DNAM-1 receptor could be used as new molecular target for treating autoimmune diseases

Autoimmune diseases occur when an individual's immune system fights their own body as if it was a foreign invader. However, in healthy people, these responses are prevented by a process known as immune tolerance

19 May 2021

Western diet impairs the gut immune system, could increase risk of inflammatory bowel disease

Eating a Western diet impairs the immune system in the gut in ways that could increase risk of infection and inflammatory bowel disease, according to a study from researchers at Washington University School of Medicine in St. Louis and Cleveland Clinic.

18 May 2021

Researchers link “genetic signatures” of bacteria in the human gut to multiple diseases

We are truly never alone, not even within our own bodies. Human beings play host to trillions of bacteria, fungi, viruses, and other microorganisms that make up the human microbiome.

18 May 2021

ErbB inhibitor lapatinib exhibits potent anti-SARS-CoV-2 activity

A team of scientists from the USA and Belgium has recently revealed that the ErbB family of receptor tyrosine kinases play a vital role in regulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lifecycle in host cells and that inhibition of these receptors can protect against SARS-CoV-2-induced acute and chronic lung injuries and inflammation.

18 May 2021

Dendritic cells can take a shortcut to reach the lymph nodes more quickly

In its response to pathogens and vaccines, our immune system relies on dendritic cells. These white blood cells patrol the body's tissues, collect components of pathogens and vaccines and transport them via lymphatic vessels to the nearest lymph node.

18 May 2021

Inflammation News and Research

Asthma patients can benefit from type 2 diabetes medication

Dupilumab considerably reduced asthma exacerbations in young children, shows VOYAGE trial

Phase 3 trial: New biologic therapy improves outcomes in adults, adolescents with severe asthma

Are COVID-19-related complications in children explained by abnormal immune responses?

Triple-drug therapy can reduce asthma exacerbations, improve control without major adverse events

Four months of multi-drug therapy for tuberculosis is as effective as standard regimen

Study shows DHA can reduce early preterm births

Antithrombotic endothelial dysfunction is prevented by Tie2 activation in severe COVID-19

Potential immunotherapy may improve cognitive and behavioral functions after stroke

Secondhand smoke during pregnancy linked to epigenetic changes in babies

Toll-like receptor 2 (TLR2) detects the SARS-CoV-2 envelope protein and generates inflammatory cytokines

Researchers propose new way to treat chronic lung condition

DNAM-1 receptor could be used as new molecular target for treating autoimmune diseases

Western diet impairs the gut immune system, could increase risk of inflammatory bowel disease

Researchers link “genetic signatures” of bacteria in the human gut to multiple diseases

ErbB inhibitor lapatinib exhibits potent anti-SARS-CoV-2 activity

Dendritic cells can take a shortcut to reach the lymph nodes more quickly

A potential treatment to prevent obesity-related liver damage

Heart Research UK awards grant for a research project investigating how COVID-19 damages blood vessels

Androgens play a critical role in regulating stomach inflammation in mice

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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