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Researchers discover the mechanism for heart complications from immune checkpoint inhibitors

Myocarditis is a complication that can occur in cancer patients treated with immune checkpoint inhibitors.

16 Nov 2022

Key Alzheimer’s gene alters the way cholesterol moves around the brain, research finds

A gene recognized as the strongest risk factor for Alzheimer's disease (AD) alters the way cholesterol moves around the brain and as we age, this altered movement likely contributes to loss of learning and memory, a team of researchers from the Icahn School of Medicine at Mount Sinai and the Massachusetts Institute of Technology reports.

16 Nov 2022

Amyloid-PET scanning has misled the FDA into granting approval for Aduhelm

Last year, the FDA gave accelerated approval of the antibody aducanumab (marketed as Aduhelm by Biogen) for the treatment of Alzheimer's disease.

16 Nov 2022

Machine learning algorithm predicts a tumor’s response to immune checkpoint blockade

Predicting which patients will respond well to treatment is a quandary that has plagued the field of cancer immunotherapy for more than four decades.

16 Nov 2022

Study could form the basis of blood testing for people at high risk of breast cancer

Researchers have found changes in the levels of particular proteins in people's blood up to two years before they were diagnosed with breast cancer.

16 Nov 2022

Research findings could bolster the effectiveness of immune-checkpoint therapy

Immune checkpoint inhibitors such as Keytruda and Opdivo work by unleashing the immune system's T cells to attack tumor cells.

16 Nov 2022

Novel nasal vaccine approach induces potent lung immunity and protection against SARS-CoV-2

Researchers from the Centenary Institute and the University of Sydney have developed a new nasal vaccination strategy that induces potent lung immunity and protection against the SARS-CoV-2 coronavirus.

16 Nov 2022

Nerve cell discovery may improve treatment options for patients with neurodegenerative diseases

A discovery that may improve treatment options for patients with neurodegenerative diseases has been made by scientists at King's College London and the University of Bath in the UK.

16 Nov 2022

Scientists explore links between survival motor neuron protein and sarcopenia

Adopting some of the strategies behind successfully treating the childhood disease spinal muscular atrophy may enable development of therapies to curb the muscle decline that accompanies aging, new research suggests.

15 Nov 2022

COVID-19 mRNA boosters induce robust but non-durable immune response in the elderly

A study published in the journal Frontiers in Immunology describes that the third booster dose of coronavirus disease 2019 (COVID-19) effectively induces an immune response against immunologically more fit variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the immunity induced by the booster vaccination is transient and gradually declines over time.

15 Nov 2022

Protein levels in lung tumors may predict prognosis, improve treatment and diagnostics

Lung cancer is the leading cause of cancer deaths globally and a top cause of cancer deaths in the Military Health System.

15 Nov 2022

Development of a potent, broadly protective vaccine against all SARS-CoV-2 variants

In a recent study published in the journal npj Vaccines, researchers in China designed, produced, and evaluated the neutralization efficacy of a recombinant coronavirus disease 2019 (COVID-19) vaccine containing four hot-spot substitution mutations based on a prefusion-stabilized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (S) trimer.

15 Nov 2022

Error-prone DNA replication and repair may lead to cancer in people with inherited BRCA1 mutations

Error-prone DNA replication and repair may lead to mutations and cancer in individuals who inherit a mutant copy of the BRCA1 gene, according to a new study by Weill Cornell Medicine investigators.

15 Nov 2022

Research sheds light on cardiac pathology mechanisms of COVID-19

Researchers compared cardiac autopsy samples from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive cases with age-matched samples from influenza hemagglutinin 1 neuraminidase 1 (H1N1) cases, non-influenza lymphocytic myocarditis cases, and heart tissue with no inflammation to understand the mechanisms underlying the pathology of the cardiac complications during coronavirus disease 2019 (COVID-19).

15 Nov 2022

Protein C News and Research

Researchers discover the mechanism for heart complications from immune checkpoint inhibitors

Key Alzheimer’s gene alters the way cholesterol moves around the brain, research finds

Amyloid-PET scanning has misled the FDA into granting approval for Aduhelm

Machine learning algorithm predicts a tumor’s response to immune checkpoint blockade

Study could form the basis of blood testing for people at high risk of breast cancer

Research findings could bolster the effectiveness of immune-checkpoint therapy

Novel nasal vaccine approach induces potent lung immunity and protection against SARS-CoV-2

Nerve cell discovery may improve treatment options for patients with neurodegenerative diseases

Scientists explore links between survival motor neuron protein and sarcopenia

COVID-19 mRNA boosters induce robust but non-durable immune response in the elderly

Protein levels in lung tumors may predict prognosis, improve treatment and diagnostics

Development of a potent, broadly protective vaccine against all SARS-CoV-2 variants

Error-prone DNA replication and repair may lead to cancer in people with inherited BRCA1 mutations

Research sheds light on cardiac pathology mechanisms of COVID-19

Polyphenols in Mediterranean diet may modulate COVID-19 inflammation

What are the current challenges and future directions of mRNA nanomedicine?

Study highlights link between the induction of fever and antibody levels after COVID-19 mRNA vaccine

Obesity-related gut damage associated with increase in asthma severity

Minimally invasive reporter system allows highly sensitive monitoring of RNA production

Behind the Scenes of the Oncology & Precision Medicine Conferences 2022

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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