Therapeutics News and Research

RSS

Researchers identify 43 specific genes associated with both autism and cancer

Autism and cancer share more than 40 risk genes, suggesting that common mechanisms underlying the functions of some of these genes could conceivably be leveraged to develop therapies not just for cancer but for autism as well, an extensive assessment by researchers with the UC Davis MIND Institute and Comprehensive Cancer Center has found.

4 May 2016

Study reveals long-term health-related quality of life in bariatric surgery patients

Significant improvement in health-related quality of life was reported by patients 12-14 years after undergoing an uncommon form of bariatric surgery at one U.S. medical center. Follow-up of the 27 patients who underwent biliary pancreatic diversion surgery with duodenal switch (BPD-DS) by the same surgeon is described in an article in Bariatric Surgical Practice and Patient Care, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free for download until June 2, 2016.

3 May 2016

Fish oil supplements combined with anti-cancer therapy can reduce renal cell carcinoma

Researchers at UC Davis have shown that docosahexaenoic acid (DHA), a fatty acid commonly found in fish and fish oil supplements, reduces renal cell carcinoma invasiveness, growth rate, and blood vessel growth when combined with the anti-cancer therapy regorafenib. The study was published in the journal Molecular Cancer Therapeutics.

3 May 2016

Promising method may help identify new antimicrobials to target CRE infection

In recent years, hospitals have reported dramatic increases in the number of cases of the highly contagious, difficult-to-treat, and often deadly antibiotic-resistant bacteria carbapenem-resistant Enterobacteriaceae (CRE). Now, investigators at Beth Israel Deaconess Medical Center have developed a promising method of identifying new antimicrobials that target these organisms. The research is published in April issue of the journal ASSAY and Drug Development Technologies.

30 Apr 2016

Mitochondrial dysfunction linked to chemotherapeutic resistance in African-American men with prostate cancer

Improper functioning of the mitochondria, a cell's source of energy, may help account for the fact that African-American men with prostate cancer respond poorly to the same conventional therapies provided to Caucasian-American men, according to research led by Dhyan Chandra, PhD, Associate Professor of Oncology in the Department of Pharmacology and Therapeutics at Roswell Park Cancer Institute.

30 Apr 2016

Cubresa's new NuPET scanner enables simultaneous PET/MRI in existing third-party MRI systems

A compact PET scanner called NuPET has been commercially released for simultaneous preclinical PET (Positron Emission Tomography) and MRI (Magnetic Resonance Imaging) in existing third-party MRI systems.

From Cubresa Inc. 29 Apr 2016

Experimental therapy has over 90% remission rate for advanced leukemia patients

Twenty-seven of 29 patients with an advanced type of leukemia that had proved resistant to multiple other forms of therapy went into remission after their T cells (disease-fighting immune cells) were genetically engineered to fight their cancers.

28 Apr 2016

Musashi-2 protein regulates function, development of blood stem cells

Researchers at McMaster University's Stem Cell and Cancer Research Institute have made significant steps forward in understanding the stem cells of the human blood system after discovering how a key protein allows for better control and regeneration of these cells.

28 Apr 2016

Existing non-antibiotic therapeutic drugs could help combat antibiotic-resistant pathogens

The rise of antibiotic resistant bacterial pathogens is an increasingly global threat to public health. In the United States alone antibiotic resistant bacterial pathogens kill thousands every year.

27 Apr 2016

University of Leicester-led researchers solve 3D structure of NuRD complex that plays role in cancer

A team of researchers led by the University of Leicester has shed new light on how the regulation machinery that controls gene expression works by characterising a complex known as the NuRD complex.

27 Apr 2016

Newly published manuscripts enhance understanding of the immune system

MedImmune, the global biologics research and development arm of AstraZeneca, today announced that it has achieved a significant scientific milestone by publishing three manuscripts in Nature Immunology that advance the understanding of the immune system and highlight underlying mechanisms in two little-understood disease areas -- chronic obstructive pulmonary disease (COPD) and systemic lupus erythematosus (SLE).

26 Apr 2016

UK charity Action on Hearing Loss funds new project to develop medicines for hearing loss

Today, UK charity Action on Hearing Loss announces a major investment to fund a new project to develop medicines to treat age-related hearing loss and noise-induced hearing loss at BioTrinity 2016 – Europe’s Leading Investment and Biopartnering Conference.

26 Apr 2016

Resolving HBV infection does not reduce liver cancer risk

Long-term infection with hepatitis B virus (HBV) can cause liver inflammation and increase the risk of liver cancer. Researchers from the US Centers for Disease Control and Prevention, however, found that resolving HBV infection was not associated with reduced rates of liver cancer.

25 Apr 2016

Nocturnal hypoxemia closely linked to diabetic microvascular complications

Examining the poorly understood link between obstructive sleep apnea (OSA) and type 2 diabetes complications, researchers identified specific measures of low blood oxygenation that are associated with impaired kidney function and diabetic nephropathy.

25 Apr 2016

First breakthrough in gene therapy against aging

In September 2015, then 44 year-old CEO of BioViva USA Inc. Elizabeth Parrish received two of her own company's experimental gene therapies: one to protect against loss of muscle mass with age, another to battle stem cell depletion responsible for diverse age-related diseases and infirmities.

25 Apr 2016

Under-expressed miR-9 gene may contribute to schizophrenia risk

By turning skin cells into brain neurons, researchers at the Icahn School of Medicine at Mount Sinai have identified that certain tiny molecules aiding in gene expression, known as microRNAs (miRNAs), are under-expressed in the brains of the 14 schizophrenia patients they studied. Their findings, published online today in the journal Cell Reports, show that one of these molecules, a miRNA known as miR-9, is a risk factor that controls the activity of hundreds of genes.

22 Apr 2016

CUMC researchers identify new neurodevelopmental syndrome

A multicenter research team led by Columbia University Medical Center has discovered a new neurodevelopmental syndrome and the genetic mutations that cause it. The discovery is an important step toward creating targeted therapies for individuals with this syndrome, which causes severe developmental delays, abnormal muscle tone, seizures, and eye complications.

22 Apr 2016

Infected mice can be better models for human diseases

Vaccines and therapeutics developed using mice often don't work as expected in humans. New research at Washington University School of Medicine in St. Louis points to the near-sterile surroundings of laboratory mice as a key reason.

21 Apr 2016

Better way to model human immune system

Scientists at the University of Minnesota have developed a new way to study mice that better mimics the immune system of adult humans and which could significantly improve ways to test potential therapeutics. Published online today in the journal Nature, the researchers describe the limitations of laboratory mice for immunology research and reveal the benefits of what they are calling "dirty mice."

21 Apr 2016

TNF-alpha protein involved in autoimmune diseases may also promote tissue healing

As its name suggests, inflammatory bowel disease, which afflicts more than 1.6 million Americans, involves chronic inflammation of all or some of the digestive tract. An autoimmune disease known to have a strong genetic component, its symptoms are abdominal cramps, bloody diarrhea, and fever and, sometimes, weight loss. IBD, which is a group of inflammatory conditions, includes Crohn's disease and ulcerative colitis.

21 Apr 2016

Therapeutics News and Research

Researchers identify 43 specific genes associated with both autism and cancer

Study reveals long-term health-related quality of life in bariatric surgery patients

Fish oil supplements combined with anti-cancer therapy can reduce renal cell carcinoma

Promising method may help identify new antimicrobials to target CRE infection

Mitochondrial dysfunction linked to chemotherapeutic resistance in African-American men with prostate cancer

Cubresa's new NuPET scanner enables simultaneous PET/MRI in existing third-party MRI systems

Experimental therapy has over 90% remission rate for advanced leukemia patients

Musashi-2 protein regulates function, development of blood stem cells

Existing non-antibiotic therapeutic drugs could help combat antibiotic-resistant pathogens

University of Leicester-led researchers solve 3D structure of NuRD complex that plays role in cancer

Newly published manuscripts enhance understanding of the immune system

UK charity Action on Hearing Loss funds new project to develop medicines for hearing loss

Resolving HBV infection does not reduce liver cancer risk

Nocturnal hypoxemia closely linked to diabetic microvascular complications

First breakthrough in gene therapy against aging

Under-expressed miR-9 gene may contribute to schizophrenia risk

CUMC researchers identify new neurodevelopmental syndrome

Infected mice can be better models for human diseases

Better way to model human immune system

TNF-alpha protein involved in autoimmune diseases may also promote tissue healing

Next-generation therapeutics eBook eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Latest News