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Study finds no major difference in effectiveness of two classes of drugs in peritoneal dialysis patients

With cardiovascular disease being the No. 1 cause of death in end-stage kidney disease patients on peritoneal dialysis, a new study examined two classes of medications commonly prescribed to prevent cardiovascular events in these patients and found no significant difference in outcomes.

9 Aug 2016

Gasotransmitters in the body could potentially be used to develop new drugs

Gases once thought of only as environmental pollutants are now known to be produced by the body. They could potentially be used to develop drugs to treat diseases including heart failure and cancer.

8 Aug 2016

Novel therapeutic strategy could target multiple aspects of Alzheimer's disease

Therapeutic strategies targeting Alzheimer's disease (AD)-related molecule β-amyloid (Aβ), Tau protein and BACE enzyme have been recently explored. However the therapeutic efficacy for a single target is not ideal.

8 Aug 2016

Research shows alcohol abuse drug inhibits ocular conjunctival scarring in mouse model

New research from University College London, Moorfields Eye Hospital and Duke University School of Medicine has identified a gene that drives scarring, together with a rapidly translatable therapy, for the UK's most common cause of blinding conjunctivitis.

4 Aug 2016

Brazilian study discovers promising therapeutic and diagnostic target for treatment of melanoma

A Brazilian study shows that inhibition of an RNA named RMEL3, which is encoded by a previously uncharacterized gene (also named RMEL3), can reduce the viability of cultured melanoma cells by up to 95%.

4 Aug 2016

Studies highlight key role for vitamin A metabolite retinoic acid in ocular fibrosis

Mucous membrane pemphigoid is an autoimmune disease that causes inflammation and scarring in mucosal tissues. Affected individuals frequently exhibit scarring in the eye, which can lead to blindness in as many as 20% of patients.

4 Aug 2016

Rice University bioengineer receives NIH grant to study use of AAV-based therapy to combat ovarian cancer

Rice University bioengineer Junghae Suh has been awarded a prestigious R01 grant by the National Institutes of Health to research the use of viral gene therapy to fight ovarian cancer.

3 Aug 2016

Biologists discover male-harming mtDNA mutant that substantiates mother's curse hypothesis

There is new evidence that the "mother's curse" - the possibility that moms may transmit genes to their children that harm their sons but not their daughters - holds true in animals.

3 Aug 2016

Bochum-based scientists explore regeneration measures for athletes in elite sports

In a joint project, Bochum-based researchers headed by Prof Dr Alexander Ferrauti and Prof Dr Michael Kellmann studied the best possible regeneration measures for athletes after strenuous training and competition phases.

2 Aug 2016

Iron-containing catalysts can alter amino acids to help develop new drug candidates

For medicinal chemists, making tweaks to peptide structures is key to developing new drug candidates. Now, researchers have demonstrated that two iron-containing small-molecule catalysts can help turn certain types of amino acids -- the building blocks of peptides and proteins -- into an array of potential new forms, even when part of a larger peptide, while preserving a crucial aspect of their chemistry: chirality, or "handedness."

2 Aug 2016

Ortho Clinical Diagnostics to showcase seven posters of vital tests, six products at AACC meeting

Ortho Clinical Diagnostics today announced it will present seven scientific posters on its assays and display six products at its booth at the 2016 American Association for Clinical Chemistry annual meeting.

30 Jul 2016

VALIDATE D-Dimer kit from LGC Maine Standards receives US FDA approval for use on hemostasis test systems

LGC Maine Standards is pleased to announce our VALIDATE D-Dimer calibration verification / linearity test kit has received US FDA 510(k) clearance for use on Instrument Laboratory ACL TOP hemostasis test systems.

30 Jul 2016

DRG International to present Aldosterone ELISA Kit at 2016 AACC

DRG International, a leading international medical diagnostic company, will showcase its DRG Aldosterone ELISA Kit at the 2016 AACC in Philadelphia, Pennsylvania on August 02-04.

30 Jul 2016

Tecan’s D300e Digital Dispenser offers quick liquid transfer down to picoliter levels

Tecan has introduced the D300e Digital Dispenser for applications that need faster, reliable dispensing down to picoliter volumes.

From Tecan 30 Jul 2016

Study verifies human gene therapy in MPS I animal model

Researchers are closer to finding a better way to treat children with a rare metabolic disorder called MPS I. It is caused by a deficiency of the key enzyme IDUA needed to break down complex sugars in cells.

29 Jul 2016

Novel method sheds light on how disruption in LRRK2 gene causes inherited Parkinson's disease

Scientists have developed a new method of measuring the activity of disease-causing mutations in the LRRK2 gene, a major cause of inherited Parkinson's disease.

29 Jul 2016

T-cell technology could be used to treat ovarian tumors with no adverse effects

With only incremental improvements in ovarian cancer survival over the last 40 years, there is a clear need for new treatment options with long-lasting results. Many researchers have turned toward the development of immunotherapies that direct T-cells to selectively eliminate ovarian tumor cells, but an appropriate therapeutic target for ovarian cancers has remained elusive.

29 Jul 2016

Scientists identify novel way to target lung cancer through KRAS gene

UT Southwestern Medical Center researchers have identified a new way to target lung cancer through the KRAS gene, one of the most commonly mutated genes in human cancer and one researchers have so far had difficulty targeting successfully.

29 Jul 2016

New study to examine genomics of anti-platelet therapy after coronary interventions

Which antiplatelet medication is best after a coronary stent? The Tailored Antiplatelet Therapy to Lessen Outcomes After Percutaneous Coronary Intervention (TAILOR-PCI) Study examines whether prescribing heart medication based on a patient's CYP2C19 genotype will help prevent heart attack, stroke, unstable angina, and cardiovascular death in patients who undergo percutaneous coronary intervention (PCI), commonly called angioplasty.

29 Jul 2016

New gene therapy shows promising results for treating neurodegenerative disorders

A new gene therapy approach designed to replace the enzyme that is deficient in patients with the inherited neurodegenerative disorders Tay-Sachs and Sandhoff diseases successfully delivered the therapeutic gene to the brains of treated mice, restored enzyme function, and extended survival by about 2.5-fold.

28 Jul 2016

Enzyme News and Research

Study finds no major difference in effectiveness of two classes of drugs in peritoneal dialysis patients

Gasotransmitters in the body could potentially be used to develop new drugs

Novel therapeutic strategy could target multiple aspects of Alzheimer's disease

Research shows alcohol abuse drug inhibits ocular conjunctival scarring in mouse model

Brazilian study discovers promising therapeutic and diagnostic target for treatment of melanoma

Studies highlight key role for vitamin A metabolite retinoic acid in ocular fibrosis

Rice University bioengineer receives NIH grant to study use of AAV-based therapy to combat ovarian cancer

Biologists discover male-harming mtDNA mutant that substantiates mother's curse hypothesis

Bochum-based scientists explore regeneration measures for athletes in elite sports

Iron-containing catalysts can alter amino acids to help develop new drug candidates

Ortho Clinical Diagnostics to showcase seven posters of vital tests, six products at AACC meeting

VALIDATE D-Dimer kit from LGC Maine Standards receives US FDA approval for use on hemostasis test systems

DRG International to present Aldosterone ELISA Kit at 2016 AACC

Tecan’s D300e Digital Dispenser offers quick liquid transfer down to picoliter levels

Study verifies human gene therapy in MPS I animal model

Novel method sheds light on how disruption in LRRK2 gene causes inherited Parkinson's disease

T-cell technology could be used to treat ovarian tumors with no adverse effects

Scientists identify novel way to target lung cancer through KRAS gene

New study to examine genomics of anti-platelet therapy after coronary interventions

New gene therapy shows promising results for treating neurodegenerative disorders

Biochemical Assays for Efficient Hit Prioritization After Screening eBook

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