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Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis

In a new study published in Circulation Research, Chen-Yu Zhang and Xiaohong Jiang's group from Nanjing University and Dongjin Wang's group from Nanjing Drum Tower Hospital reported a critical role of PGC1α in maintaining the contractile phenotype of vascular smooth muscle cells (VSMCs) and highlighted the therapeutic potential of PGC1α for atherosclerosis.

25 Jun 2021

Study could help identify genes linked to aging process

To better understand the role of bacteria in health and disease, National Institutes of Health researchers fed fruit flies antibiotics and monitored the lifetime activity of hundreds of genes that scientists have traditionally thought control aging.

25 Jun 2021

Researchers trace gecko’s skin tumors to a gene implicated in deadly cancer

The leopard gecko's name was Mr. Frosty, and he was hard to miss. Yellow bands striped his back, and uncommonly white skin peeked out from speckles on his head and tail.

25 Jun 2021

Mutations in HER2 gene can spur tumor growth in breast cancer

Mutations in a gene related to HER2, a gene frequently implicated in breast cancers and a variety of other malignancies, can amplify activity that spurs tumor growth, a new study led by UT Southwestern researchers suggests.

25 Jun 2021

Researchers decode humans’ survival from historical coronavirus outbreaks

An international team of researchers co-led by the University of Adelaide and the University of Arizona has analyzed the genomes of more than 2,500 modern humans from 26 worldwide populations, to better understand how humans have adapted to historical coronavirus outbreaks.

25 Jun 2021

New findings shed light on genetic changes that underlie rare, aggressive childhood cancer

A new study could lead to improved decision making in assigning treatments for children with the aggressive cancer rhabdomyosarcoma after revealing key genetic changes underlying development of the disease.

24 Jun 2021

UCLA scientists discover how immune cells can be trained to fight potential threats

The body's immune cells naturally fight off viral and bacterial microbes and other invaders, but they can also be reprogrammed or "trained" to respond even more aggressively and potently to such threats, report UCLA scientists who have discovered the fundamental rule underlying this process in a particular class of cells.

24 Jun 2021

Turning down glial genes can help mitigate Huntington's disease pathogenesis

The brain is not a passive recipient of injury or disease. Research has shown that when neurons die and disrupt the natural flow of information they maintain with other neurons, the brain compensates by redirecting communications through other neuronal networks.

24 Jun 2021

Researchers create first detailed atlas of the developing mouse brain

Researchers at Harvard University and the Broad Institute of MIT and Harvard have created a first detailed atlas of a critical region of the developing mouse brain, applying multiple advanced genomic technologies to the part of the cerebral cortex that is responsible for processing sensation from the body.

24 Jun 2021

Study: A subset of patients with localized prostate cancer may benefit from immunotherapies

In recent years, cancer immunotherapy has been effective in treating patients with immunogenic, or so-called "hot" tumors with increased levels of inflammation and the presence of immune cells in and around the tumors.

24 Jun 2021

Common cause of rare syndromes revealed by cultured mini-brains

The culprit behind a large number of cancerous tumors is known to be a certain protein. Now for the first time, research shows that the same protein is the cause of several rare brain syndromes.

24 Jun 2021

SARS-CoV-2 causes ER-stress-activated unfolded protein response leading to cell death

A new study describes the varying ways in which the virus co-opts the machinery of the host cell following infection to evade or modulate the host immune response, alter the pattern of translation of viral proteins, and the release of new viral particles.

24 Jun 2021

Researchers discover a molecular pathway that triggers fatal cardiac atrophy

In many situations, heart muscle cells do not respond to external stresses in the same ways that skeletal muscle cells do. But under some conditions, heart and skeletal muscles can both waste away at fatally rapid rates, according to a new study led by experts at Cincinnati Children's.

24 Jun 2021

Researchers identify the origins of seven types of kidney cancer

The origins of seven types of kidney cancer, including several rare subtypes, have been identified by researchers at the Wellcome Sanger Institute, Great Ormond Street Hospital (GOSH), the Princess Máxima Center for Pediatric Oncology and Oncode Institute.

24 Jun 2021

Internal communication network in mammals provides new insights on obesity, skin disorders

National Institutes of Health scientists and their collaborators have identified an internal communication network in mammals that may regulate tissue repair and inflammation, providing new insights on how diseases such as obesity and inflammatory skin disorders develop. The new research is published in Cell.

24 Jun 2021

Genes News and Research

Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis

Study could help identify genes linked to aging process

Researchers trace gecko’s skin tumors to a gene implicated in deadly cancer

Mutations in HER2 gene can spur tumor growth in breast cancer

Researchers decode humans’ survival from historical coronavirus outbreaks

New findings shed light on genetic changes that underlie rare, aggressive childhood cancer

UCLA scientists discover how immune cells can be trained to fight potential threats

Turning down glial genes can help mitigate Huntington's disease pathogenesis

Researchers create first detailed atlas of the developing mouse brain

Study: A subset of patients with localized prostate cancer may benefit from immunotherapies

Common cause of rare syndromes revealed by cultured mini-brains

SARS-CoV-2 causes ER-stress-activated unfolded protein response leading to cell death

Researchers discover a molecular pathway that triggers fatal cardiac atrophy

Researchers identify the origins of seven types of kidney cancer

Internal communication network in mammals provides new insights on obesity, skin disorders

New class of compounds can stop the reproduction of coronavirus

Increasing novel lncRNA in cardiomyocytes can inhibit the progression of heart failure

Researchers unravel new mechanism that enables cancer development

SARS-CoV N protein elicits production of IFN-β by provoking ubiquitination of RIG-I, finds study

Repeated vaccination could control infection with SARS-CoV-2 variants among infection-naïve individuals

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