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Study: Odorant receptor recognizes pyrazines in both humans and domesticated animals

A team of scientists from the Leibniz Institute for Food Systems Biology at the Technical University of Munich has now discovered that the odorant receptor OR5K1 is specialized to recognize pyrazines in both humans and domesticated animals.

23 Jun 2021

Researchers discover new class of drugs that inhibits a 'master switch' in mantle cell lymphoma

A new class of drugs that inhibits a "master switch" involved in the vast majority of cases of mantle cell lymphoma (MCL), a fatal subtype of non-Hodgkin's lymphoma, has been discovered by researchers at Mount Sinai.

22 Jun 2021

Molecular study reveals signs of inflammation in brains of people who died of COVID-19

The most comprehensive molecular study to date of the brains of people who died of COVID-19 turned up unmistakable signs of inflammation and impaired brain circuits.

22 Jun 2021

Testing several genes can provide precise knowledge about the choice of right medicinal products

Most of us have genetic variations that increase the risk of medicinal products not being effective. In order to provide a more effective treatment with fewer side effects, we need to analyse more of these genetic variations.

22 Jun 2021

Combination of biological markers could improve triage and risk prediction in dengue patients

Researchers have identified a combination of biological markers in patients with dengue that could predict whether they go on to develop moderate to severe disease, according to a study published today in eLife.

22 Jun 2021

Smoother silicone breast implants can reduce inflammation and other immune system reactions

According to researchers at Johns Hopkins Medicine, the Massachusetts Institute of Technology (MIT) and Rice University in Houston, silicone breast implants with a smoother surface design have less risk of producing inflammation and other immune system reactions than those with more roughly textured coatings.

22 Jun 2021

Researchers develop new therapeutic approach for treating acute myeloid leukemia

Leukemia stem cells are rare cells that can renew themselves while continuing to generate malignant cells known as leukemic blasts. These cells are difficult to eradicate using chemotherapy drugs and frequently lead to recurrence of leukemia.

22 Jun 2021

New human organoid mimics the earliest developmental steps of the nervous system in embryos

The progression from a round ball of cells to an embryo with a head and a tail is one of the most critical steps in an organism's development. But just how cells first start organizing themselves with directionality along this head-to-tail axis is hard to study because it happens in the earliest days of embryonic development, in the confines of a mammal's uterus.

22 Jun 2021

Dual-antibody combination therapies effective against SARS-CoV-2 variants in animal study

COVID-19 therapies made from antibodies often are given to patients who are at high risk of severe illness and hospitalization. However, there have been nagging questions about whether such antibody therapies retain their effectiveness as worrisome new virus variants arise.

21 Jun 2021

Could the European hedgehog be a sentinel for infectious agents and a harbinger of environmental pollution?

A recent review paper by Portuguese and Spanish authors, recently published in the journal Biologics, revealed the current state of knowledge regarding hedgehog health – most notably the presence of infectious agents, diseases and other threats that can affect the health of the population.

21 Jun 2021

Study details health risks, growth patterns, and treatment outcomes of people with achondroplasia

In a retrospective study believed to be one of the largest of its kind, researchers say they have successfully charted the health risks, growth patterns, and medical and surgical outcomes of 1,374 people with the most common form of dwarfism, called achondroplasia, seen over a 60-year period at four academic medical centers, including Johns Hopkins Medicine.

21 Jun 2021

Study reviews natural drug candidates for potential treatment of COVID-19

A recent paper in the Saudi Journal of Biological Sciences seeks to open up new approaches by reviewing a list of compounds derived from plants and other natural sources, which have potential inhibitory activity against the coronavirus.

21 Jun 2021

Viral phosphoesterases (including in CoVs) can restrict antiviral innate immunity

An interesting new study describes the activities of a family of viral enzymes called two-histidine-phosphoesterases (2H-PEs), found in coronaviruses (CoVs) and rotaviruses, as well as a mammalian A-kinase anchoring protein enzyme, AKAP7, that shares the same function. Together called 2’,5’-PEs, these enzymes all break down 2’,5’-oligoadenylate compounds that activate the antiviral enzyme ribonuclease L (RNase L).

21 Jun 2021

COVID-19 studies should provide sex-disaggregated data, researchers warn

Researchers have warned that studies examining sex-specific responses to infection with SARS-CoV-2 must provide sex-disaggregated data.

21 Jun 2021

Can a prior rhinovirus infection protect against COVID-19?

Researchers at the Yale School of Medicine found that rhinovirus accelerates interferon-stimulated genes.

21 Jun 2021

Targeting lung inflammation with cell membrane-based dexamethasone nanodelivery platform

Recently, researchers discuss their development of cell membrane-based nanoparticles that successfully delivered dexamethasone directly to inflamed lung cells.

21 Jun 2021

New test is cheaper, easier, and can reliably diagnose SARS-CoV-2 infection

New lateral flow test Vigilant is cheaper, easier to use and as reliable as the current gold standard PCR test for diagnosing SARS-CoV-2 infection.

21 Jun 2021

Researchers discover genetic cause of neurodevelopmental disorder

University of Maryland School of Medicine (UMSOM) researchers identified a new gene that may be linked to certain neurodevelopmental disorders and intellectual disabilities.

21 Jun 2021

Role of tau in pathogenesis of Lewy body dementias is distinct from Alzheimer’s disease, suggests study

Will a reduction in tau protein in brain neurons protect against Parkinson's disease and Lewy body dementias?

21 Jun 2021

Study uncovers new mechanisms underlying lineage plasticity

Cancer cells have an uncanny ability to evolve and adapt to overcome the treatments used against them. While patient survival has been extended by modern drugs that block the production or action of male hormones that fuel prostate cancer -- androgen receptor inhibitors such as enzalutamide, apalutamide, darolutamide, and abiraterone -- eventually these drugs stop working.

21 Jun 2021

Genes News and Research

Study: Odorant receptor recognizes pyrazines in both humans and domesticated animals

Researchers discover new class of drugs that inhibits a 'master switch' in mantle cell lymphoma

Molecular study reveals signs of inflammation in brains of people who died of COVID-19

Testing several genes can provide precise knowledge about the choice of right medicinal products

Combination of biological markers could improve triage and risk prediction in dengue patients

Smoother silicone breast implants can reduce inflammation and other immune system reactions

Researchers develop new therapeutic approach for treating acute myeloid leukemia

New human organoid mimics the earliest developmental steps of the nervous system in embryos

Dual-antibody combination therapies effective against SARS-CoV-2 variants in animal study

Could the European hedgehog be a sentinel for infectious agents and a harbinger of environmental pollution?

Study details health risks, growth patterns, and treatment outcomes of people with achondroplasia

Study reviews natural drug candidates for potential treatment of COVID-19

Viral phosphoesterases (including in CoVs) can restrict antiviral innate immunity

COVID-19 studies should provide sex-disaggregated data, researchers warn

Can a prior rhinovirus infection protect against COVID-19?

Targeting lung inflammation with cell membrane-based dexamethasone nanodelivery platform

New test is cheaper, easier, and can reliably diagnose SARS-CoV-2 infection

Researchers discover genetic cause of neurodevelopmental disorder

Role of tau in pathogenesis of Lewy body dementias is distinct from Alzheimer’s disease, suggests study

Study uncovers new mechanisms underlying lineage plasticity

eBook: Using iPSCs models for human disease research and drug discovery eBook

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