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Drebrin autoantibodies trigger epilepsy

Certain forms of epilepsy are accompanied by inflammation of important brain regions. Researchers at the University of Bonn have now identified a mechanism that explains this link.

24 Mar 2020

NYUAD researchers develop new microfluidic platform to perform cancer liquid biopsies

Cancer is one of the leading causes of death worldwide, and has been found to have a significantly higher rate of survival when diagnosed at early stages, before metastasis.

23 Mar 2020

Study provides better understanding of how dangerous cancer metastases arise

In order to colonize other organs and grow into metastases, tumor cells that detach from the parent tumor need to manipulate their new microenvironment and create a 'metastatic niche'.

23 Mar 2020

AI could enhance prediction of treatment response among patients with non-small cell lung cancer

Artificial intelligence deep learning algorithms may predict response to systemic treatment for non-small cell lung cancer.

23 Mar 2020

Stem cells establish contacts with nerves in tissue regeneration and cancer progression

Researchers at the University of Zurich show that different stem cell populations are innervated in distinct ways.

23 Mar 2020

Using 'young NK cells' could improve the effectiveness of immunotherapy for cancer patients

Immunotherapy that involves treating cancer with the body's own immune cells, or those of a matched donor, shows promise in clinical trials for some patients, but not all.

22 Mar 2020

Plasma monitoring of EGFR mutations in NSCLC may help predict resistance to tyrosine kinase inhibitors

Oncotarget Volume 11, Issue 11 reported that at clinical progression, 64 EGFR T790M plasma positive patients were subjected to second line-treatment with osimertinib and strictly monitored during the first month of therapy.

22 Mar 2020

Researchers invent new method to map sugar structures of blood-thinning drug

The blood-thinning drug heparin is used all over the world. But, the underlying sugar structures of heparin and the wider family of heparan sulfate sugars in cells have not been fully mapped.

22 Mar 2020

Some hospitals continue with elective surgeries despite COVID-19 crisis

In the same week that physicians at the University of California-San Francisco medical center were wiping down and reusing protective equipment like masks and gowns to conserve resources amid a surge of COVID-19 patients, 90 miles away teams of doctors at UC Davis Medical Center were fully suited up performing breast augmentations, hip replacements and other elective procedures that likely could have been postponed.

21 Mar 2020

Preclinical study characterizes the binding affinity and selectivity of a selective FLT3 inhibitor

Oncotarget Volume 11, Issue 11 reported that in this preclinical study, we characterized the binding affinity and selectivity of quizartinib, a small-molecule inhibitor of FLT3, and AC886, the active metabolite of quizartinib, compared with those of other FLT3 inhibitors.

21 Mar 2020

Researchers discover why some prostate cancers are more aggressive

Researchers at the University of East Anglia have discovered why some prostate cancers are more aggressive, spread to different parts of the body, and ultimately cause death.

20 Mar 2020

AI may help predict tumor sensitivity to systemic cancer therapies

Using standard-of-care computed tomography scans in patients with advanced non-small cell lung cancer, researchers utilized artificial intelligence to train algorithms to predict tumor sensitivity to three systemic cancer therapies.

20 Mar 2020

Immunotherapy treatment shows promise for some patients with advanced rare cancers

A study conducted by researchers at The University of Texas MD Anderson Cancer Center demonstrated acceptable toxicity and anti-tumor activity in patients with four types of advanced, hard-to-treat rare cancers.

20 Mar 2020

Novel MRI contrast agent for early detection of brain metastases

A group of researchers led by Leif Schroeder from the Leibniz-Forschungsinstitut fuer Molekulare Pharmakologie have found a way to detect metastases in certain types of cancer in the brain at an early stage, using only minimal amounts of contrast agent.

19 Mar 2020

Study offers new insight into genetic alterations associated with osteosarcoma

A study by researchers at the National Cancer Institute, part of the National Institutes of Health, offers new insight into genetic alterations associated with osteosarcoma, the most common cancerous bone tumor of children and adolescents.

19 Mar 2020

Study helps predict which ovarian cancer patients will not benefit from immune-PARP combo

In patients with advanced ovarian cancer, a combination of drugs known as immune checkpoint inhibitors and PARP inhibitors can produce powerful remissions, clinical trials have shown, but up until now investigators haven't been able to predict which patients won't benefit from the treatment and should explore other options.

19 Mar 2020

Study paves way for identifying ovarian cancer patients who will not benefit from combination therapy

A study suggests it may be possible to identify those who will not benefit from drug combination for advanced ovarian cancer.

19 Mar 2020

Bacteria-trapping protein may contribute to breast cancer metastasis

The protein peptidyl arginine deiminase 4 (PAD4), which enables some immune cells to trap bacteria, promoted breast cancer metastasis in mice when expressed in cancer cells, according to data published in Molecular Cancer Research, a journal of the American Association for Cancer Research.

19 Mar 2020

Targeting PI3Kβ alone and with combination therapy in PTEN-deficient tumors

The cover for issue 11 of Oncotarget features Figure 6, "Effects of AZD8186 in combination with anti-PD1 on syngeneic models," by Owusu-Brackett, et al.

18 Mar 2020

MCL1 protein essential in protecting the intestine against cancer development

An international team of researchers from the University of Zurich, the University Hospital Zurich, Heidelberg and Glasgow has identified a novel function for the cell death regulating protein MCL1: It is essential in protecting the intestine against cancer development – independent of bacterial-driven inflammation.

18 Mar 2020

Tumor News and Research

Drebrin autoantibodies trigger epilepsy

NYUAD researchers develop new microfluidic platform to perform cancer liquid biopsies

Study provides better understanding of how dangerous cancer metastases arise

AI could enhance prediction of treatment response among patients with non-small cell lung cancer

Stem cells establish contacts with nerves in tissue regeneration and cancer progression

Using 'young NK cells' could improve the effectiveness of immunotherapy for cancer patients

Plasma monitoring of EGFR mutations in NSCLC may help predict resistance to tyrosine kinase inhibitors

Researchers invent new method to map sugar structures of blood-thinning drug

Some hospitals continue with elective surgeries despite COVID-19 crisis

Preclinical study characterizes the binding affinity and selectivity of a selective FLT3 inhibitor

Researchers discover why some prostate cancers are more aggressive

AI may help predict tumor sensitivity to systemic cancer therapies

Immunotherapy treatment shows promise for some patients with advanced rare cancers

Novel MRI contrast agent for early detection of brain metastases

Study offers new insight into genetic alterations associated with osteosarcoma

Study helps predict which ovarian cancer patients will not benefit from immune-PARP combo

Study paves way for identifying ovarian cancer patients who will not benefit from combination therapy

Bacteria-trapping protein may contribute to breast cancer metastasis

Targeting PI3Kβ alone and with combination therapy in PTEN-deficient tumors

MCL1 protein essential in protecting the intestine against cancer development

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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