Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Using a vaccine to boost the response of engineered T cells

Engineering T cells to destroy cancer cells has shown success in treating some types of cancer, such as leukemia and lymphoma. However, it hasn't worked as well for solid tumors.

5 Jul 2023

Biomarker found in urine could help diagnose acute tubulointerstitial nephritis

In a study led by Johns Hopkins Medicine, in collaboration with Yale School of Medicine, researchers have identified a biomarker found via a simple urine test that can be used to diagnose acute tubulointerstitial nephritis (AIN), a medical condition that causes inflammation of the kidneys and can lead to acute kidney injury (AKI) — a sudden loss of kidney function.

5 Jul 2023

Study identifies role of ROR1 in pancreatic cancer metastasis

Tumor-initiating cells, or cancer stem cells, are gaining attention in cancer therapy, as they can travel through the body and cause cancerous tumors at other sites through metastasis.

5 Jul 2023

Purecap method offers hope for purer and safer mRNA vaccines

A research group from Japan has developed a method to produce highly active mRNA vaccines at high purity using a unique cap to easily separate the desired capped mRNA.

5 Jul 2023

Reproductive impact of changes in the vaginal microbiome of obese women

Study explores the impact of obesity on vaginal microbiota and reproduction.

5 Jul 2023

Fit to beat diabetes: mendelian randomization study confirms the power of exercise

Researchers investigated the causality of the relationship between cardiorespiratory fitness and diabetes mellitus type 2.

5 Jul 2023

Beyond the lungs: SARS-CoV-2's multi-organ impact revealed

Researchers present the mechanisms by which SARS-CoV-2 could infect the brain and affect memory.

5 Jul 2023

Spicing up rheumatic disease treatment: Study explores role of herbs and spices in improving patients' condition

Research explores the potential benefits of herbs and spices in rheumatic diseases, highlighting their bioactive compounds and medicinal properties. It provides an updated review of their mechanisms of action and summarizes human studies in Rheumatoid Arthritis, Osteoarthritis, and Fibromyalgia.

4 Jul 2023

A novel RSV vaccine that could be effective across all ages

Researchers evaluate the in vivo efficacy of a respiratory syncytial virus vaccine in old and young rats.

4 Jul 2023

EPFL scientists develop an innovative method for reconstructing Tau fibrils

EPFL scientists have developed ClearTau, an innovative method and platform for reconstructing aggregates of the protein Tau found in Alzheimer's disease and other neurodegenerative diseases.

4 Jul 2023

SYS6006 investigational COVID-19 mRNA vaccine shows promise as fourth dose booster

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in more than 600 million confirmed cases and 6.5 million deaths worldwide.

4 Jul 2023

Crunching the numbers: assessing Hungary's reluctance towards entomophagy

Study explores the rate of insect consumption in Hungary over the five years between 2016 and 2021.

4 Jul 2023

Growth factor study reveals potential breakthrough in obesity management

Study discusses the effects of a growth factor that showed promising results in mice in an obesity trial.

4 Jul 2023

Smoking and HPV found to increase risk of head and neck cancer

Tobacco smoking and human papillomavirus (HPV) are both well-known risk factors for head and neck cancer, but there is ample evidence to show they can interact to increase still further the risk of contracting the disease, according to a study by scientists at the University of São Paulo (USP) in Brazil and the University of Chile.

3 Jul 2023

New regulatory system discovered in malaria parasite

Gene expression within the apicoplast, an organelle in the malaria parasite Plasmodium falciparum, is regulated by melatonin (the circadian signaling hormone) in host blood, and intrinsic parasite cues, via a factor called ApSigma, as identified by a recent study aided by Tokyo Tech's World Research Hub Initiative.

3 Jul 2023

Mutations in AGC kinase motif linked to colorectal cancer growth

Cancer spreads throughout the human body in cunning, almost militaristic, ways. For example, it can manipulate our genetic make-up, take over specific cell-to-cell signaling processes, and mutate key enzymes to promote tumor growth, resist therapies, and hasten its spread from the original site to the bloodstream or other organs.

3 Jul 2023

CRISPR/Cas9-based screening identifies potential therapies for non-alcoholic fatty liver disease

Activation of the NRF2 transcription factor shows promise as a potential treatment approach for non-alcoholic fatty liver disease (NAFLD), a condition associated with oxidative stress and liver damage. By screening FDA-approved drugs, researchers identified six compounds that enhanced NRF2 activity and demonstrated protective effects against oxidative stress and lipid accumulation.

3 Jul 2023

SIRT1: Unlocking the secrets to better vascular health through resveratrol and energy restriction

Research investigates the effects of SIRT1 activation through resveratrol supplementation and energy restriction on vascular function in adults. The study reveals that both interventions increase circulating SIRT1, reduce sympathetic activity, and have positive impacts on vascular reactivity, indicating potential benefits for vascular health.

3 Jul 2023

Resistance training could be a simple and affordable therapy for Alzheimer's patients

Regular physical exercise, such as resistance training, can prevent Alzheimer's disease, or at least delay the appearance of symptoms, and serves as a simple and affordable therapy for Alzheimer's patients.

3 Jul 2023

Ancient retrovirus may be responsible for aggressive brain cancers

The median length of survival after diagnosis of glioblastoma is 14 months, but some of these brain tumors are more aggressive and resistant to treatment than others, and a new study from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine suggests reactivation of an ancient retrovirus may be at least partly to blame.

3 Jul 2023