Protein C News and Research

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Researchers find an innovative approach to improve waste clearance from the brain

Alzheimer's, Parkinson's and many other neurodegenerative diseases are marked by damaging clusters of proteins in the brain. Scientists have expended enormous effort searching for ways to treat such conditions by clearing these toxic clusters but have had limited success.

9 Nov 2022

OHSU discovery could suggest new avenues to treat symptoms of Parkinson's disease

Researchers at Oregon Health & Science University have discovered that the neurotransmitter adenosine effectively acts as a brake to dopamine, another well-known neurotransmitter involved in motor control.

9 Nov 2022

Can prostaglandin E2 injection improve hair growth?

A new study demonstrated that prostaglandin E2 (PGE2) stimulates hair follicle growth.

9 Nov 2022

Researchers propose a deep antibody-antigen interaction algorithm to accelerate the identification of potential therapeutic antibodies

Researchers used a deep antibody-antigen interaction (DeepAAI) algorithm to understand the antibody representations of unseen antibodies to accelerate the discovery of novel antibodies with potential therapeutic applications.

9 Nov 2022

Highly processed and refined foods contribute to rising obesity rates in the Western world

A year-long study of the dietary habits of 9,341 Australians has backed growing evidence that highly processed and refined foods are the leading contributor of rising obesity rates in the Western world.

9 Nov 2022

Collaboration aims to develop new medicines for neurodegenerative diseases

The ALBORADA Drug Discovery Institute (ADDI) today (Tuesday 8 November) announced that it will collaborate with pharmaceutical company YD Global Life Science (YDGLS) to develop inhibitors of the unfolded protein response for the treatment of the diseases that cause dementia.

9 Nov 2022

Study indicates widespread SARS-CoV-2 exposure in wildlife

In a recent study posed to the bioRxiv* preprint server, researchers at Virginia Tech University investigated wildlife exposure to SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2).

8 Nov 2022

Nutritional interventions targeting key oxidative process can improve motivation

In life, motivation can be the difference between success and failure, goal-setting and aimlessness, well-being and unhappiness.

8 Nov 2022

Researchers use lasso-grafting for designing receptor agonists with enhanced pharmacokinetics

Cell growth and repair are stimulated by biomolecules known as cytokines and growth factors. Unfortunately, delivering adequate concentrations of these molecules to the brain for treating neurological conditions like Alzheimer's disease is challenging as they are either cleared out of the blood very quickly or do not penetrate neural tissue effectively.

8 Nov 2022

Scientists determine 5,072 essential human genes

In a recent study published in the journal Cell, researchers examined the phenotypic landscape of multiple elusive essential human genes to create a detailed genotype-phenotype resource outlining the phenotypic consequences of disrupting fundamental cellular processes.

8 Nov 2022

Protein complex may present strong therapeutic target for lethal breast cancer

Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have shown that a protein complex that governs gene expression (called CoREST) sometimes gets rewired during breast cancer to help estrogen receptor positive (ER+) tumors resist endocrine therapies and become more aggressive.

8 Nov 2022

Combination treatment does not slow radiographic spinal progression in radiographic axSpA patients

New research presented this week at ACR Convergence 2022, the American College of Rheumatology's annual meeting, showed that combining a nonsteroidal anti-inflammatory drug and TNF inhibitor did not significantly slow radiographic spinal progression in radiographic axial spondyloarthritis patients.

8 Nov 2022

Study identifies novel inhibitors against SARS-CoV-2 main protease

In a recent study posted to the bioRxiv* server, researchers at the University of Arizona screened ~11 million severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro)-inhibiting small compounds in the ZINC15 database using a structure-based in-silico screening method.

8 Nov 2022

New breakthrough could help spot lung cancer earlier and improve patient outcomes

Scientists investigating the mechanics of the early stages of lung cancer have identified a new potential treatment, which could also aid early detection of the disease.

8 Nov 2022

New urine tests for early diagnosis of chronic kidney disease

Early diagnosis of chronic kidney disease (CKD) is key to managing progression of the disease. A new technique analyzing urine extracellular vesicles (uEVs) - cell-derived nanoscale spherical structures involved in multiple biological functions - in urine samples identifies changes in the kidneys earlier than conventional methods and can also predict renal function decline.

8 Nov 2022

Does vitamin D reduce COVID-19 severity?

A new study examined published studies for a consistent association between vitamin D levels and coronavirus disease 2019 (COVID-19) severity.

8 Nov 2022

Hybrid immunity from vaccination and Omicron BA.1 or BA.5 breakthrough infections exhibits cross-reactive efficacy against BA.2.75

Researchers recently measured the neutralizing antibody titers against the wild-type strain of SARS-CoV-2 and the SARS-CoV-2 Omicron subvariants in healthcare workers fully vaccinated with three doses of the Comirnaty vaccine who experienced breakthrough Omicron infections.

8 Nov 2022

Researchers unravel genetic changes in a region that controls the activity of the genome

Scientists have discovered the cause of a rare condition within a part of the genome that has been largely unexplored in medical genetics. A team at the University of Exeter has found genetic changes in a region that controls the activity of the genome, turning on or off genes, and in doing so they have found a key that could unlock other causes of rare conditions.

8 Nov 2022

Low-protein highly processed foods lead to higher energy intake

8 Nov 2022

Study identifies a potential pharmacological target for treating COVID-19-associated heart failure

Researchers at the University of Maryland School of Medicine's (UMSOM) Center for Precision Disease Modeling identified how a specific protein in SARS-CoV-2, the virus responsible for COVID-19, damages heart tissue. They then used a drug to reverse the toxic effects of that protein on the heart.

8 Nov 2022

Protein C News and Research

Researchers find an innovative approach to improve waste clearance from the brain

OHSU discovery could suggest new avenues to treat symptoms of Parkinson's disease

Can prostaglandin E2 injection improve hair growth?

Researchers propose a deep antibody-antigen interaction algorithm to accelerate the identification of potential therapeutic antibodies

Highly processed and refined foods contribute to rising obesity rates in the Western world

Collaboration aims to develop new medicines for neurodegenerative diseases

Study indicates widespread SARS-CoV-2 exposure in wildlife

Nutritional interventions targeting key oxidative process can improve motivation

Researchers use lasso-grafting for designing receptor agonists with enhanced pharmacokinetics

Scientists determine 5,072 essential human genes

Protein complex may present strong therapeutic target for lethal breast cancer

Combination treatment does not slow radiographic spinal progression in radiographic axSpA patients

Study identifies novel inhibitors against SARS-CoV-2 main protease

New breakthrough could help spot lung cancer earlier and improve patient outcomes

New urine tests for early diagnosis of chronic kidney disease

Does vitamin D reduce COVID-19 severity?

Hybrid immunity from vaccination and Omicron BA.1 or BA.5 breakthrough infections exhibits cross-reactive efficacy against BA.2.75

Researchers unravel genetic changes in a region that controls the activity of the genome

Low-protein highly processed foods lead to higher energy intake

Study identifies a potential pharmacological target for treating COVID-19-associated heart failure

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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