Therapy News and Research

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The safety of short-course compared to long-course antibiotic therapy for ventilator-associated pneumonia

Researchers performed a meta-analysis of randomized controlled trials to evaluate the safety of short-course antibiotic treatment versus long-course antibiotic treatment for ventilator-associated pneumonia.

7 Mar 2023

Could smartphones be used for anemia screening?

In a recent study published in the PLOS ONE journal, researchers assessed the feasibility of smartphone facial colorimetry as an anemia screening technique.

7 Mar 2023

Quality improvement initiative successfully reduced urine culture testing for asymptomatic bacteriuria and catheter-associated asymptomatic bacteriuria

Researchers reported on the execution of two electronic healthcare record interventions for reducing urine culture ordering in asymptomatic bacteriuria and catheter-associated ASB in a low-resource safety net system.

7 Mar 2023

CDC recommendations and clinical considerations for the treatment of severe Mpox

In a recent article published in the United States (U.S.) Centers for Disease Control and Prevention's (CDC) Morbidity and Mortality Weekly Report, a team of researchers discussed the medical countermeasures and clinical considerations for treating severe manifestations of Mpox.

6 Mar 2023

Antibody levels from prime COVID-19 mRNA vaccine influences the efficacy of booster doses

Researchers evaluate the response of pre-existing immunity to booster doses of mRNA COVID-19 vaccines.

6 Mar 2023

Tumors' response to hormone therapy may be a biomarker for personalization of breast radiotherapy

How estrogen receptor-positive (ER+) breast cancer responds to hormone therapy may hold keys to understanding how it will respond to radiation therapy, and an experimental drug that increases the effectiveness of hormone therapy also overcomes radiation resistance in breast cancer, a study by UT Southwestern Medical Center researchers shows.

6 Mar 2023

A measure of residual inflammatory risk may be a powerful predictor of future cardiovascular events

New evidence released today from a study of 31,245 patients already taking statin therapy indicates that inflammation may be a more powerful predictor of risk of future cardiovascular events - such as heart attack and stroke - than "bad" cholesterol.

6 Mar 2023

Evaluating how bacterial therapeutics may synergize with existing anti-cancer therapies

It may come as a surprise, but bacteria love to grow inside tumors. It's the environment - tumors are typically acidic, have low amounts of oxygen, and are filled with dead cells, which all facilitate bacterial growth.

6 Mar 2023

How SARS-CoV-2 infection affects acute ischemic stroke outcomes

A recent PLOS ONE journal study evaluated the impact of COVID-19 on neurological outcomes in acute ischemic stroke patients.

6 Mar 2023

New research pinpoints key culprit behind brain cancer metastasis in children

New research pinpoints a key cause of metastasis from an aggressive form of brain cancer in children and provides a potential new therapy for treating these tumors in the future.

6 Mar 2023

LDL cholesterol levels reduced by oral PCSK9 inhibitor in phase 2 trial

MK-0616, an experimental oral proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, met its primary endpoint and substantially reduced levels of low-density lipoprotein (LDL) cholesterol in people with high cholesterol and/or heart disease related to clogged arteries, in a study being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Addition of sotatercept to existing therapy shows promise for the treatment of pulmonary arterial hypertension

Patients with pulmonary arterial hypertension (PAH), a severe, progressive condition that affects the heart and lungs, who were treated with the novel first-in-class medication sotatercept on top of existing therapy experienced significant improvements in walking distance via a six-minute walking test—the study's primary endpoint and a validated surrogate for functional improvement and reduced symptom burden.

6 Mar 2023

Fighting pancreatic cancer with gene and cell biotherapies

Pancreatic cancer is an incurable form of cancer, and gene therapies are currently in clinical testing to treat this deadly disease. A comprehensive review of the gene and cell biotherapies in development to combat pancreatic cancer is published in the peer-reviewed journal Human Gene Therapy.

6 Mar 2023

Fixed-dose combination therapy provides better results than monotherapy for pulmonary hypertension

Patients with pulmonary arterial hypertension (high blood pressure in the arteries that supply the lungs, also called PAH) had approximately double the reduction in pulmonary vascular resistance (PVR) if they took the PAH medications macitentan (10 mg) and tadalafil (40 mg) together in a single tablet rather than either drug alone, according to research being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Coordinated, multifaceted intervention can improve preventive care for diabetes, heart disease

A multifaceted intervention to improve prescribing practices increased the likelihood that patients with Type 2 diabetes and heart disease would be prescribed three classes of guideline-recommended medications by more than fourfold, according to research being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

BioInfect: Bringing the best brains to the challenge of antimicrobial resistance

During the conference, we had the chance to catch up with some of the speakers to ask them about their work, as well as what they would be discussing at the 2023 BioInfet Conference.

6 Mar 2023

Expansion of the innovative aphasia therapy program will improve access to quality treatment

More people with aphasia will have access to quality treatment, particularly those in rural and regional areas, thanks to the expansion of a University of Queensland developed therapy program.

5 Mar 2023

Review highlights the effectiveness of diet-based low-density lipoprotein lowering over medication

In a recent article published in the journal Nutrition, researchers in Australia summarized how diet could help decrease low-density lipoprotein cholesterol (LDLc) or triglyceride concentrations in polygenic hypercholesterolemia.

5 Mar 2023

Automated reminders improve guideline-based statin prescribing practices

Patients with cardiovascular disease, such as heart disease, stroke or peripheral arterial disease, were significantly more likely to be prescribed guideline-recommended high-intensity statin therapy if their clinician was sent an automated reminder with information about their cardiovascular disease history, prior statin use and history of statin associated side effects, according to research being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

5 Mar 2023

Transcatheter-based mitral valve repair safe and effective for nearly 9 out of 10 patients

The largest study to examine outcomes for patients treated outside a clinical trial setting with a minimally invasive procedure to repair a poorly functioning mitral valve in the heart found that the procedure was safe and resulted in a successful repair for nearly 9 out of 10 patients, researchers reported at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology. Patients whose procedure was successful were half as likely to die within one year compared with those in whom the procedure was unsuccessful.

5 Mar 2023

Therapy News and Research

The safety of short-course compared to long-course antibiotic therapy for ventilator-associated pneumonia

Could smartphones be used for anemia screening?

Quality improvement initiative successfully reduced urine culture testing for asymptomatic bacteriuria and catheter-associated asymptomatic bacteriuria

CDC recommendations and clinical considerations for the treatment of severe Mpox

Antibody levels from prime COVID-19 mRNA vaccine influences the efficacy of booster doses

Tumors' response to hormone therapy may be a biomarker for personalization of breast radiotherapy

A measure of residual inflammatory risk may be a powerful predictor of future cardiovascular events

Evaluating how bacterial therapeutics may synergize with existing anti-cancer therapies

How SARS-CoV-2 infection affects acute ischemic stroke outcomes

New research pinpoints key culprit behind brain cancer metastasis in children

LDL cholesterol levels reduced by oral PCSK9 inhibitor in phase 2 trial

Addition of sotatercept to existing therapy shows promise for the treatment of pulmonary arterial hypertension

Fighting pancreatic cancer with gene and cell biotherapies

Fixed-dose combination therapy provides better results than monotherapy for pulmonary hypertension

Coordinated, multifaceted intervention can improve preventive care for diabetes, heart disease

BioInfect: Bringing the best brains to the challenge of antimicrobial resistance

Expansion of the innovative aphasia therapy program will improve access to quality treatment

Review highlights the effectiveness of diet-based low-density lipoprotein lowering over medication

Automated reminders improve guideline-based statin prescribing practices

Transcatheter-based mitral valve repair safe and effective for nearly 9 out of 10 patients

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

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