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St. Jude scientists develop interactive tool to advance understanding of mutations that fuel pediatric cancer

St. Jude Children's Research Hospital scientists have developed a web application and data set that gives researchers worldwide a powerful interactive tool to advance understanding of the mutations that lead to and fuel pediatric cancer. The freely available tool, called ProteinPaint, is described in today's issue of the scientific journal Nature Genetics.

30 Dec 2015

Researchers identify new gene that helps maintain chromosome number in cells

Molecular biologists at UT Southwestern Medical Center have identified a gene called NORAD that helps maintain the proper number of chromosomes in cells, and that when inactivated, causes the number of chromosomes in a cell to become unstable, a key feature of cancer cells.

26 Dec 2015

3D maps of spatial organization may help find genes involved in hereditary diseases

It has now been 15 years since scientists celebrated the completion of the human genome. At that point, scientists had determined the entire sequence of the genetic letters making up our DNA.

26 Dec 2015

Father-daughter duo co-author research paper on new grapefruit cybrids

When Jude Grosser's daughter, Melinda, was in elementary school, he would often take her to his laboratory at the University of Florida's Citrus Research and Education Center, where he works as a researcher on citrus diseases and creating new varieties.

26 Dec 2015

Researchers identify liver-derived hormone that regulates sugar intake

We all love our sugar, especially during the holidays. Cookies, cake, and candy are simply irresistible. While sugar cravings are common, the physiological mechanisms that trigger our "sweet tooth" are not well defined.

24 Dec 2015

Healthier weight using genetic data for customized diets and physical activity plans

Some health experts predict that the next big advance in helping overweight people achieve a healthier weight will be to use an individual's genetic data to customize diets and physical activity plans, an approach known as "precision weight loss.

24 Dec 2015

Computers could discover future drugs

The drugs of tomorrow may be discovered by computers. A proof-of-concept study published December 23 in Cell Systems demonstrates that with the right input of data about infectious yeast, a machine algorithm can learn to identify combinations of existing and previously unknown compounds that can work together as antifungal agents.

24 Dec 2015

Personalised approach may help identify patients’ response to certain cancer treatments

Many people in Russia know about the Dima Rogachev Centre - particularly those who have faced the challenge of child cancer.

23 Dec 2015

Researchers identify cause of rare syndrome consistent with Fanconi Anemia

An international team of researchers has established the cause of rare syndrome consistent with Fanconi Anemia: a de novo mutation in a so called RAD51 gene, which is responsible for repairing damages in the DNA.

23 Dec 2015

Novel drug shows promise in mouse models of human metastatic breast cancer

A doctor treating a patient with a potentially fatal metastatic breast tumor would be very pleased to find, after administering a round of treatment, that the primary tumor had undergone a change in character - from aggressive to static, and no longer shedding cells that can colonize distant organs of the body. Indeed, most patients with breast and other forms of cancer who succumb to the illness do so because of the cancer's unstoppable spread.

23 Dec 2015

Researchers reveal inherited genetic errors across 12 cancer types

Researchers long have known that some portion of the risk of developing cancer is hereditary and that inherited genetic errors are very important in some tumors but much less so in others.

22 Dec 2015

Study reveals new genetic factors linked to age-related macular degeneration

An international study of about 43,000 people has significantly expanded the number of genetic factors known to play a role in age-related macular degeneration (AMD), a leading cause of vision loss among people age 50 and older.

22 Dec 2015

Scientists identify 52 genetic variations associated with age-related macular degeneration

In one of the latest examples of precision medicine, teams of geneticists from nine countries, involving more than 100 scientists, analyzed the genes of more than 33,000 individuals in the hope of finding genetic variations responsible for age-related macular degeneration (AMD), the leading cause of vision loss among people age 50 or older.

22 Dec 2015

New easy-to-use computer program can quickly identify drug-resistant infections

Scientists have developed an easy-to-use computer program that can quickly analyse bacterial DNA from a patient's infection and predict which antibiotics will work, and which will fail due to drug resistance. The software is currently being trialled in three UK hospitals to see whether it could help speed up diagnosis of drug-resistant infections and enable doctors to better target the prescription of antibiotics.

21 Dec 2015

Roche's cobas HIV-1 viral load test approved by FDA for use on cobas 6800 and cobas 8800 Systems

Roche announced today that it has received FDA approval for the cobas HIV-1 viral load test by the United States Food and Drug Administration for use on the cobas 6800 and cobas 8800 Systems. This HIV-1 viral load test is part of the next generation of Roche viral load tests, which clinicians use to manage the disease and treatment of patients infected with HIV-1.

21 Dec 2015

AES Annual Meeting takes our understanding of epilepsy to next level

Epilepsy remains one of the most common neurological conditions, affecting one in 26 Americans in their lifetime, with one-third having a form of the condition that resists treatment or effective management. With those statistics in mind, more than 5,200 neurologists, scientists, nurses and health professionals came to Philadelphia December 4-8 for the 2015 American Epilepsy Society Annual Meeting to discuss new discoveries and emerging technologies that can lead to more effective treatment.

18 Dec 2015

Research opens door to validation studies in multiple tumor types of liquid biopsy

Pancreatic cancer tumors spill their molecular secrets into the blood stream, shedding their complete DNA and RNA wrapped inside protective lipid particles that make them ripe for analysis with a liquid biopsy, researchers at The University of Texas MD Anderson Cancer Center report online at the Annals of Oncology.

18 Dec 2015

UA developing brain-scanning technology that could improve diagnosis of many disorders

Researchers at the University of Arizona are developing a noninvasive brain-scanning technology that could produce images far superior to those obtained with the most commonly used systems -- electroencephalography and functional magnetic resonance imaging.

17 Dec 2015

UMMS researchers identify new life cycle stage in HIV infection

Researchers at the University of Massachusetts Medical School have identified a new life cycle stage in HIV infection, thanks to a novel technique they developed to take images of intact infected cells.

17 Dec 2015

Mitochondrial variation and viable pregnancy: an interview with Dr Elpida Fragouli

Embryos require adequate amounts of energy so that they can successfully progress through each of their cell divisions.

16 Dec 2015

Genome News and Research

St. Jude scientists develop interactive tool to advance understanding of mutations that fuel pediatric cancer

Researchers identify new gene that helps maintain chromosome number in cells

3D maps of spatial organization may help find genes involved in hereditary diseases

Father-daughter duo co-author research paper on new grapefruit cybrids

Researchers identify liver-derived hormone that regulates sugar intake

Healthier weight using genetic data for customized diets and physical activity plans

Computers could discover future drugs

Personalised approach may help identify patients’ response to certain cancer treatments

Researchers identify cause of rare syndrome consistent with Fanconi Anemia

Novel drug shows promise in mouse models of human metastatic breast cancer

Researchers reveal inherited genetic errors across 12 cancer types

Study reveals new genetic factors linked to age-related macular degeneration

Scientists identify 52 genetic variations associated with age-related macular degeneration

New easy-to-use computer program can quickly identify drug-resistant infections

Roche's cobas HIV-1 viral load test approved by FDA for use on cobas 6800 and cobas 8800 Systems

AES Annual Meeting takes our understanding of epilepsy to next level

Research opens door to validation studies in multiple tumor types of liquid biopsy

UA developing brain-scanning technology that could improve diagnosis of many disorders

UMMS researchers identify new life cycle stage in HIV infection

Mitochondrial variation and viable pregnancy: an interview with Dr Elpida Fragouli

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