Inflammation News and Research

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Host protein mimicry of SARS-CoV-2 receptor binding motif

In a new study, structural bioinformatics approaches are employed to investigate the potential mimicry of the receptor-binding motif (RBM) of these three coronaviruses, finding that several proteins from both human and non-human sources were similar to each, with implications regarding the mechanism of infection and tropism of SARS-CoV-2.

29 Apr 2021

Is Hong Kong’s fourth wave of COVID-19 due to the Q57H SARS-CoV-2 variant?

A recent article in the Centers for Disease Control and Prevention (CDC)’s Emerging Infectious Diseases reveals that the last of these was probably due to the introduction of a new variant from Nepal. This novel variant had been circulating in the community for about a month before the last outbreak was reported.

29 Apr 2021

Processed diets may promote diseases characterized by low-grade infection and inflammation

Processed diets, which are low in fiber, may initially reduce the incidence of foodborne infectious diseases such as E. coli infections, but might also increase the incidence of diseases characterized by low-grade chronic infection and inflammation such as diabetes, according to researchers in the Institute for Biomedical Sciences at Georgia State University.

28 Apr 2021

Early MR imaging can greatly increase the diagnosis of broken-heart syndrome

In almost ten per cent of myocardial infarctions, no obvious cause in the coronary artery can be found. Some of the patients are diagnosed with broken-heart syndrome, while others are left without a diagnosis.

28 Apr 2021

Horizontal transmission route is responsible for HTLV-1 uveitis

Human T-cell lymphotropic virus type-1 (HTLV-1) is a retrovirus similar to human immunodeficiency virus (HIV) and has mostly been thought to be transmitted vertically (mother-to-child), or horizontally (sexually or parenterally (e.g. via blood transfusion)).

28 Apr 2021

Study reveals the role of lncRNAs in immune dysfunction during severe COVID-19

Scientific studies rarely focus on long non-coding RNA molecules (lncRNAs), even though they potentially regulate several diseases. The role of several lncRNAs in anti-viral inflammatory response regulation has recently been reported.

28 Apr 2021

Regular exercise improves vascular function in patients with autoimmune rheumatic diseases

The risk of developing atherosclerosis - a narrowing of the arteries as cholesterol plaque builds up, leading to obstruction of blood flow - is higher for people with autoimmune rheumatic diseases than for the general population.

27 Apr 2021

UCI biologists develop new mouse model to study late-onset Alzheimer's disease

University of California, Irvine biologists have developed a new genetically engineered mouse model that, unlike its predecessors, is based on the most common form of Alzheimer's disease.

27 Apr 2021

New treatment reduces the severity of ARDS in influenza-infected mice

A new treatment is among the first known to reduce the severity of acute respiratory distress syndrome caused by the flu in animals, according to a new study.

27 Apr 2021

Placental-derived stem cell therapy shows promise to heal intestinal disease in premature babies

An intestinal bowel disease that affects up to 10 percent of premature infants at a very vulnerable and developmentally crucial time can lead to serious infection and death.

27 Apr 2021

NUS study identifies protein that could be targeted to overcome chemoresistance in cancer

Chemotherapy is a drug treatment that uses powerful chemicals to kill fast-growing cancer cells in the body. It is a systemic treatment where drugs travel throughout the body and destroy cancer cells that have spread (metastasized) to parts of the body far away from the original (primary) tumor.

27 Apr 2021

New discovery could lead to more effective treatments for fatigue-inducing anemias

A combination of inexpensive oral medications may be able to treat fatigue-inducing anemias caused by chronic diseases and inflammation, a new discovery from the University of Virginia School of Medicine suggests.

27 Apr 2021

Global hemoglobin cut-off to define anemia overestimates disease burden in Indian children

Anemia rates among children and teenagers in India may be 20 per cent lower than currently reported as diagnosis is based on ethnically inappropriate blood count thresholds, a study argues.

27 Apr 2021

Corticosteroids not recommended to treat smell loss due to Covid-19, study shows

Steroids should not be used to treat smell loss caused by Covid-19 according to an international group of smell experts, including Prof Carl Philpott from the University of East Anglia.

27 Apr 2021

Doctoral students recommend changing the protocols around use of tear gas on crowds

A new study by five doctoral students in neuroscience at the University of Minnesota Medical School calls attention to a lack of regulation and unknown long-term health effects of tear gas. Based on their research, the group recommends changing the protocols around the use of tear gas as a crowd control measure at both the local and national level.

27 Apr 2021

Research suggests that Ginkgo biloba extract contains naturally occurring inhibitors against SARS-CoV-2

Researchers at Shihezi University in China found that Gingko Biloba leaves extract contains the most potent SARS-CoV-2 3-Chymotrypsin-like protease (3CLpro). This virally encoded main proteinase is essential for viral replication in coronaviruses.

27 Apr 2021

Study reveals a hidden role of circulating microRNA as a driver of SARS-CoV-2 infection

In a methodological tour-de-force study, a large group of researchers from the USA and the United Kingdom analyzed patient transcriptomic data in-depth and discovered a circulating microRNA (miR-2392) that is directly implicated in the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) machinery during the infection process.

26 Apr 2021

Study uncovers a novel autoantigen in patients with narcolepsy type 1

Researchers at the University of Helsinki have identified influenza virus peptides that resemble human protein fragments and can cause an immune response against the body’s own cells due to cross-reactivity.

26 Apr 2021

Single dose of Pfizer-BioNTech COVID-19 vaccine induces immunity in CML patients

Researchers in the UK have shown that a single dose of the Pfizer-BioNTech vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induced antibody and cellular responses in patients with chronic myeloid leukemia (CML) who were taking tyrosine kinase inhibitors.

25 Apr 2021

High dose of vitamin D does not have a beneficial effect on moderate or severe COVID-19 patients

Can a high dose of vitamin D administered on admission to hospital improve the condition of patients with moderate or severe COVID-19? The answer is no, according to a Brazilian study published in the Journal of the American Medical Association.

23 Apr 2021

Inflammation News and Research

Host protein mimicry of SARS-CoV-2 receptor binding motif

Is Hong Kong’s fourth wave of COVID-19 due to the Q57H SARS-CoV-2 variant?

Processed diets may promote diseases characterized by low-grade infection and inflammation

Early MR imaging can greatly increase the diagnosis of broken-heart syndrome

Horizontal transmission route is responsible for HTLV-1 uveitis

Study reveals the role of lncRNAs in immune dysfunction during severe COVID-19

Regular exercise improves vascular function in patients with autoimmune rheumatic diseases

UCI biologists develop new mouse model to study late-onset Alzheimer's disease

New treatment reduces the severity of ARDS in influenza-infected mice

Placental-derived stem cell therapy shows promise to heal intestinal disease in premature babies

NUS study identifies protein that could be targeted to overcome chemoresistance in cancer

New discovery could lead to more effective treatments for fatigue-inducing anemias

Global hemoglobin cut-off to define anemia overestimates disease burden in Indian children

Corticosteroids not recommended to treat smell loss due to Covid-19, study shows

Doctoral students recommend changing the protocols around use of tear gas on crowds

Research suggests that Ginkgo biloba extract contains naturally occurring inhibitors against SARS-CoV-2

Study reveals a hidden role of circulating microRNA as a driver of SARS-CoV-2 infection

Study uncovers a novel autoantigen in patients with narcolepsy type 1

Single dose of Pfizer-BioNTech COVID-19 vaccine induces immunity in CML patients

High dose of vitamin D does not have a beneficial effect on moderate or severe COVID-19 patients

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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